Amyloidosis (E85) ICD-10-CM
The E85 code range covers amyloidosis with 11 ICD-10-CM diagnosis codes. 9 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
- Alzheimer's disease G30.0
Codes in the E85 Range 11 codes · 9 billable
- E85 AmyloidosisNon-billable
- E85.0 Non-neuropathic heredofamilial amyloidosis
- E85.1 Neuropathic heredofamilial amyloidosis
- E85.2 Heredofamilial amyloidosis, unspecified
- E85.3 Secondary systemic amyloidosis
- E85.4 Organ-limited amyloidosis
- E85.8 Other amyloidosisNon-billable
- E85.81 Light chain (AL) amyloidosis
- E85.82 Wild-type transthyretin-related (ATTR) amyloidosis
- E85.89 Other amyloidosis
- E85.9 Amyloidosis, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the E85 range.
Amyloid
A fibrous protein complex that consists of proteins folded into a specific cross beta-pleated sheet structure. This fibrillar structure has been found as an alternative folding pattern for a variety of functional proteins. Deposits of amyloid in the form of AMYLOID PLAQUES are associated with a variety of degenerative diseases. The amyloid structure has also been found in a number of functional proteins that are unrelated to disease.
Amyloid Neuropathies, Familial
Inherited disorders of the peripheral nervous system associated with the deposition of AMYLOID in nerve tissue. The different clinical types based on symptoms correspond to the presence of a variety of mutations in several different proteins including transthyretin (PREALBUMIN); APOLIPOPROTEIN A-I; and GELSOLIN.
Amyloidosis
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
Amyloidosis, Familial
Diseases in which there is a familial pattern of AMYLOIDOSIS.
Cerebral Amyloid Angiopathy
A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)
Cerebral Amyloid Angiopathy, Familial
A familial disorder marked by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES.
Factor X Deficiency
Blood coagulation disorder usually inherited as an autosomal recessive trait, though it can be acquired. It is characterized by defective activity in both the intrinsic and extrinsic pathways, impaired thromboplastin time, and impaired prothrombin consumption.
Immunoglobulin Light-chain Amyloidosis
A nonproliferative disorder of PLASMA CELLS characterized by excessive production and misfolding of IMMUNOGLOBULIN LIGHT CHAINS that form insoluble amyloid fibrils (see AMYLOID DEPOSITS) in various tissues. Clinical features include LIVER FAILURE; MULTIPLE MYELOMA; NEPHROTIC SYNDROME; RESTRICTIVE CARDIOMYOPATHY, and neuropathies.
About the E85 Code Range
The ICD-10 code E85 covers amyloidosis, a condition where abnormal protein deposits accumulate in organs and tissues. This section includes specific codes for different types of amyloidosis, aiding accurate diagnosis and treatment documentation.
The general ICD-10 code for amyloidosis (E85) encompasses various hereditary and acquired forms. Codes like E85.0 and E85.1 differentiate between non-neuropathic and neuropathic heredofamilial amyloidosis, respectively, addressing familial forms that may affect kidneys, heart, or brain. E85.3 identifies secondary systemic amyloidosis, often linked to chronic conditions or long-term dialysis. Organ-limited amyloidosis, coded as E85.4, specifies amyloid buildup restricted to particular organs such as skin, heart, or lungs. The codes E85.81 and E85.82 refer to specific types like light-chain (AL) amyloidosis and wild-type transthyretin-related (ATTR) amyloidosis, common in cardiac and renal disease contexts. Unspecified and other forms are captured under E85.8, E85.89, and E85.9. Including synonyms like familial amyloid polyneuropathy or AA amyloidosis helps medical coders accurately assign the right code when these alternative terms appear in clinical documentation.
Questions About This Page
How many billable codes are in the E85 range?
Of the 11 codes in this range, 9 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the E85 range classify?
The range classifies amyloidosis. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
