Amyloidosis (E85) ICD-10-CM
The E85 code range covers amyloidosis with 11 ICD-10-CM diagnosis codes. 9 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Type 2 Excludes
A type 2 excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
- Alzheimer's disease G30.0
Codes in the E85 Range 11 codes · 9 billable
- E85 AmyloidosisNon-billable
- E85.0 Non-neuropathic heredofamilial amyloidosis
- E85.1 Neuropathic heredofamilial amyloidosis
- E85.2 Heredofamilial amyloidosis, unspecified
- E85.3 Secondary systemic amyloidosis
- E85.4 Organ-limited amyloidosis
- E85.8 Other amyloidosisNon-billable
- E85.81 Light chain (AL) amyloidosis
- E85.82 Wild-type transthyretin-related (ATTR) amyloidosis
- E85.89 Other amyloidosis
- E85.9 Amyloidosis, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the E85 range.
AL Amyloidosis
The most common type of amyloidosis. It is characterized by the monoclonal deposition of immunoglobulin light chain fragments in organs and tissues. It is associated with plasma cell or B-cell lymphoproliferative disorders.
Amyloidosis
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
About the E85 Code Range
Amyloidosis involves abnormally folded proteins that form amyloid deposits. These deposits can displace normal tissue and disrupt its function.
E85 separates familial or inherited forms by whether they involve nerves: E85.0 is non-neuropathic, E85.1 is neuropathic, and E85.2 leaves that distinction unspecified. E85.3 identifies secondary systemic amyloidosis, while E85.4 identifies amyloidosis limited to an organ.
Within other amyloidosis, E85.81 identifies light chain (AL), E85.82 identifies wild-type transthyretin-related (ATTR), and E85.89 identifies other forms. E85.9 leaves the type unspecified.
Questions About This Page
How many billable codes are in the E85 range?
Of the 11 codes in this range, 9 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the E85 range classify?
The range classifies amyloidosis. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
