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  6. 2026 ICD-10-CM Code E88.12

2026 ICD-10-CM Diagnosis Code E88.12

Generalized lipodystrophy

ICD-10-CM Code:
E88.12
ICD-10 Code for:
Generalized lipodystrophy
Is Billable?
Yes - Valid for Submission
Code Navigator:

E88.12 is a billable diagnosis code used to specify a medical diagnosis of generalized lipodystrophy. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2025 through September 30, 2026.

Code Classification

  • Endocrine, nutritional and metabolic diseases
    E00–E89
    • Metabolic disorders
      E70-E88
      • Other and unspecified metabolic disorders
        E88

Approximate Synonyms

The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.

  • Acquired generalized lipodystrophy
  • Congenital abnormal shape of clavicle
  • Congenital anomaly of subcutaneous tissue
  • Congenital deformity of clavicle
  • Congenital deformity of shoulder
  • Congenital generalized lipodystrophy
  • Congenital generalized lipodystrophy
  • Generalized congenital lipodystrophy with myopathy
  • Keppen Lubinsky syndrome
  • Mandibuloacral dysostosis
  • Mandibuloacral dysplasia with type B lipodystrophy

Clinical Information

  • Acquired Generalized Lipodystrophy

    generalized lipodystrophy, the cause of which is not present at birth.

  • Berardinelli-Seip Congenital Lipodystrophy|Berardinelli Lipodystrophy Syndrome|Berardinelli Seip Syndrome|Congenital Generalized Lipodystrophy|Congenital Generalized Lipodystrophy|Lawrence-Seip Syndrome|Seip-Bernardinelli Syndrome|Total Lipodystrophy

    a genetic disorder caused by mutations in the agpat2 and bscl2 genes. it is characterized by lipoatrophy in the trunk, face, and extremities, hypertriglyceridemia, muscle hypertrophy, cardiomyopathy and hepatomegaly. patients develop insulin resistance, leading to diabetes mellitus.

  • CAVIN1 wt Allele|CAVIN|CGL4|Caveolae Associated Protein 1 wt Allele|Cavin-1 Gene|Congenital Generalized Lipodystrophy 4 Gene|FKSG13|PTRF|RNA Polymerase I and Transcript Release Factor Gene|TTF-I Interacting Peptide 12 Gene

    human cavin1 wild-type allele is located in the vicinity of 17q21.2 and is approximately 21 kb in length. this allele, which encodes caveolae-associated protein 1, plays a role in the regulation of rrna transcription and the formation of caveolae. mutations in the gene are associated with congenital generalized (berardinelli-seip) lipodystrophy 4.

  • Generalized Lipodystrophy

    almost complete absence of subcutaneous and/or visceral adipose tissue.

New 2026 ICD-10-CM Code

E88.12 is new to ICD-10-CM code set for the FY 2026, effective October 1, 2025. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2025. This is a new and revised code for the FY 2026 (October 1, 2025 - September 30, 2026).

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Acquired generalized lipodystrophy (AGL)
  • Berardinelli-Siep syndrome
  • Congenital generalized lipodystrophy (CGL)
  • Lawrence syndrome

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Index of External Cause of Injuries

References found for this diagnosis code in the External Cause of Injuries Index:

    • AGL(acquired generalized lipodystrophy)
    • CGL(congenital generalized lipodystrophy)
    • Lipodystrophy
      • generalized (acquired) (congenital)
    • Syndrome
      • Berardinelli-Siep
    • Syndrome
      • Lawrence

Replacement Code

E8812 replaces the following previously assigned ICD-10-CM code(s):

  • E88.1 - Lipodystrophy, not elsewhere classified

Code History

  • FY 2026 - Code Added, effective from 10/1/2025 through 9/30/2026