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  6. 2026 ICD-10-CM Code E72.538

2026 ICD-10-CM Diagnosis Code E72.538

Other specified primary hyperoxaluria

ICD-10-CM Code:
E72.538
ICD-10 Code for:
Other specified primary hyperoxaluria
Is Billable?
Yes - Valid for Submission
Code Navigator:

E72.538 is a billable diagnosis code used to specify a medical diagnosis of other specified primary hyperoxaluria. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2025 through September 30, 2026.

Code Classification

  • Endocrine, nutritional and metabolic diseases
    E00–E89
    • Metabolic disorders
      E70-E88
      • Other disorders of amino-acid metabolism
        E72

Approximate Synonyms

The following list of clinical terms are approximate synonyms, alternative descriptions, or common phrases that might be used by patients, healthcare providers, or medical coders to describe the same condition. These synonyms and related diagnosis terms are often used when searching for an ICD-10 code, especially when the exact medical terminology is unclear. Whether you're looking for lay terms, similar diagnosis names, or common language alternatives, this list can help guide you to the correct ICD-10 classification.

  • Primary hyperoxaluria
  • Primary hyperoxaluria
  • Primary hyperoxaluria type III
  • Primary hyperoxaluria, type II

Clinical Information

  • AGXT wt Allele|AGT|AGT1|AGXT1|Alanine--Glyoxylate Aminotransferase Gene|Alanine--Glyoxylate and Serine--Pyruvate Aminotransferase Gene|Alanine-Glyoxylate Aminotransferase wt Allele|Glycolicaciduria Gene|Hepatic Peroxisomal Alanine:Glyoxylate Aminotransferase Gene|L-Alanine: Glyoxylate Aminotransferase 1 Gene|Oxalosis I Gene|PH1|Primary Hyperoxaluria Type 1 Gene|SPAT|SPT|Ser-PyrAT|Serine:Pyruvate Aminotransferase Gene|TLH6

    human agxt wild-type allele is located in the vicinity of 2q37.3 and is approximately 12 kb in length. this allele, which encodes alanine-glyoxylate aminotransferase protein, is involved in gluconeogenesis, l-serine metabolism and glyoxylate detoxification. mutations in the gene are associated with primary hyperoxaluria 1.

  • GRHPR wt Allele|GLXR|GLYD|Glycerate-2-Dehydrogenase Gene|Glyoxylate and Hydroxypyruvate Reductase wt Allele|MSTP035|PH2|Primary Hyperoxaluria Type 2 Gene

    human grhpr wild-type allele is located in the vicinity of 9p13.2 and is approximately 14 kb in length. this allele, which encodes glyoxylate reductase/hydroxypyruvate reductase protein, plays a role in hydroxypyruvate and glyoxylate metabolism. mutation of the gene is associated with type ii primary hyperoxaluria.

  • Primary Hyperoxaluria

    a hereditary disorder characterized by excessive oxalate production, leading to hyperoxaluria.

  • Primary Hyperoxaluria Type I

    recessively inherited primary hyperoxaluria due to alanine-glyoxylate aminotransferase (agxt) deficiency.

  • Primary Hyperoxaluria Type II

    recessively inherited primary hyperoxaluria due to glyoxylate reductase/hydroxypyruvate reductase (grhpr) deficiency.

  • Primary Hyperoxaluria Type III

    recessively inherited primary hyperoxaluria due to mitochondrial 4-hydroxy-2-oxoglutarate aldolase (hoga1) gene mutations.

New 2026 ICD-10-CM Code

E72.538 is new to ICD-10-CM code set for the FY 2026, effective October 1, 2025. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2025. This is a new and revised code for the FY 2026 (October 1, 2025 - September 30, 2026).

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.


Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Primary hyperoxaluria, type 2
  • Primary hyperoxaluria, type 3

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Index of External Cause of Injuries

References found for this diagnosis code in the External Cause of Injuries Index:

    • Disorder(of)
      • glycine metabolism
        • hyperoxaluria
          • primary
            • specified type NEC
    • Disorder(of)
      • glycine metabolism
        • hyperoxaluria
          • primary
            • type 2
    • Disorder(of)
      • glycine metabolism
        • hyperoxaluria
          • primary
            • type 3

Replacement Code

E72538 replaces the following previously assigned ICD-10-CM code(s):

  • E72.53 - Hyperoxaluria
  • E72.53 - Primary hyperoxaluria

Code History

  • FY 2026 - Code Added, effective from 10/1/2025 through 9/30/2026