ICD-10-CM Code E88.9

Metabolic disorder, unspecified

Version 2020 Billable Code

Valid for Submission

E88.9 is a billable code used to specify a medical diagnosis of metabolic disorder, unspecified. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code E88.9 might also be used to specify conditions or terms like abnormal metabolic requirement, abnormal metabolic state in diabetes mellitus, acquired sensorineural hearing loss, acute confusional state, of metabolic origin, acute metabolic disorder, amino acid deficiency, etc

Short Description:Metabolic disorder, unspecified
Long Description:Metabolic disorder, unspecified

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code E88.9 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Abnormal metabolic requirement
  • Abnormal metabolic state in diabetes mellitus
  • Acquired sensorineural hearing loss
  • Acute confusional state, of metabolic origin
  • Acute metabolic disorder
  • Amino acid deficiency
  • Anemia due to metabolic disorder
  • Aplastic anemia associated with metabolic alteration
  • Arthropathy associated with an endocrine AND/OR metabolic disorder
  • Arthropathy due to metabolic disorder
  • Autonomic neuropathy due to metabolic disease
  • Cardiac glycogenosis
  • Carnitine deficiency
  • Carnitine deficiency due to inborn error of metabolism
  • Chronic metabolic disorder
  • Clinical manifestation of enzyme deficiency
  • Complication of procedure by succeeding disorder
  • Congenital malformation syndromes with metabolic disturbances
  • Defective biosynthesis
  • Defective metabolism
  • Dementia due to metabolic abnormality
  • Dilated cardiomyopathy secondary to metabolic disorder
  • Disorder of neurometabolic regulation
  • Enzymopathy
  • Familial cardiomyopathy
  • Familial restrictive cardiomyopathy
  • Generalized metabolic disorder
  • Glaucoma in endocrine, nutritional and metabolic diseases
  • Inborn error of metabolism
  • Inherited metabolic disorder of nervous system
  • Interstitial lung disease due to metabolic disease
  • Intrinsic staining of tooth
  • Intrinsic staining of tooth - metabolic disease
  • Localized metabolic disorder
  • Metabolic and genetic disorder affecting the liver
  • Metabolic and nutritional disorders affecting skin
  • Metabolic bone disease
  • Metabolic complication of procedures
  • Metabolic disease
  • Metabolic disorder of fetus
  • Metabolic disturbance in labor AND/OR delivery
  • Metabolic ileus
  • Metabolic myopathy
  • Metabolic presbycusis
  • Metabolic renal disease
  • Mucopolysaccharidosis cardiomyopathy
  • Myelopathy due to metabolic disorder
  • Neuropathy of upper limb due to metabolic disorder
  • Nutritional and metabolic cardiomyopathies
  • Nutritional myopathy
  • Pericarditis due to metabolic disease
  • Peripheral neuropathy due to metabolic disorder
  • Presbycusis
  • Renal tubulo-interstitial disorders in metabolic diseases
  • Restrictive cardiomyopathy secondary to familial storage disease
  • Seizures due to metabolic disorder
  • Storage disease
  • Thrombocytopenic purpura associated with metabolic disorder
  • Tremor due to metabolic disorder

Clinical Information

  • BRAIN DISEASES METABOLIC-. acquired or inborn metabolic diseases that produce brain dysfunction or damage. these include primary i.e. disorders intrinsic to the brain and secondary i.e. extracranial metabolic conditions that adversely affect cerebral function.
  • BRAIN DISEASES METABOLIC INBORN-. brain disorders resulting from inborn metabolic errors primarily from enzymatic defects which lead to substrate accumulation product reduction or increase in toxic metabolites through alternate pathways. the majority of these conditions are familial however spontaneous mutation may also occur in utero.
  • GLUCOSE METABOLISM DISORDERS-. pathological conditions in which the blood glucose cannot be maintained within the normal range such as in hypoglycemia and hyperglycemia. etiology of these disorders varies. plasma glucose concentration is critical to survival for it is the predominant fuel for the central nervous system.

Convert E88.9 to ICD-9

  • 277.9 - Metabolism disorder NOS (Approximate Flag)

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Metabolic disorders (E70-E88)
      • Other and unspecified metabolic disorders (E88)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients

Metabolic Disorders

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues, such as your liver, muscles, and body fat.

A metabolic disorder occurs when abnormal chemical reactions in your body disrupt this process. When this happens, you might have too much of some substances or too little of other ones that you need to stay healthy. There are different groups of disorders. Some affect the breakdown of amino acids, carbohydrates, or lipids. Another group, mitochondrial diseases, affects the parts of the cells that produce the energy.

You can develop a metabolic disorder when some organs, such as your liver or pancreas, become diseased or do not function normally. Diabetes is an example.

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