2026 ICD-10-CM Diagnosis Code E88.09Other disorders of plasma-protein metabolism, not elsewhere classified

ICD-10-CM Codes›E00–E89›E70-E88›E88

ICD-10-CM E88.09
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E88.09 is a billable ICD-10-CM diagnosis code for other disorders of plasma-protein metabolism, not elsewhere classified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 826 through 830, 843 through 845. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E88.09
Billable Status
Yes — Valid for Submission
Code Describes
Other disorders of plasma-protein metabolism, not elsewhere classified
Short Description
Oth disorders of plasma-protein metabolism, NEC
Parent Code
E88.0
Disorders of plasma-protein metabolism, not elsewhere classified

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE88Other and unspecified metabolic disorders
This CodeE88.09Other disorders of plasma-protein metabolism, not elsewhere classified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Analbuminemia
  • Antichymotrypsin deficiency-alpha-1
  • Autosomal variant form of transthyretin
  • Bisalbuminemia
  • Congenital analbuminemia
  • Congenital atransferrinemia
  • Congenital transferrin deficiency
  • Deficiency of choline esterase II
  • Deficiency of inosine nucleosidase
  • Disorder of plasma protein metabolism
  • Disorder of protein metabolism
  • Edema due to hypoproteinemia
  • Hereditary butyrylcholinesterase deficiency
  • Hyperalbuminemia
  • Hyperproteinemia
  • Hypoalbuminemia
  • Hypoalbuminemia due to protein calorie malnutrition
  • Hypoproteinemia
  • Macroamylasemia
  • Metabolic ascites
  • Neuropathy associated with dysproteinemias

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Bisalbuminemia

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Abnormal, abnormality, abnormalities
      • transport protein
    • Absence(of) (organ or part) (complete or partial)
      • albumin in blood
    • Analbuminemia
    • Atransferrinemia, congenital
    • Bisalbuminemia
    • Deficiency, deficient
      • enzymes, circulating NEC
    • Deficiency, deficient
      • pseudocholinesterase
    • Disorder(of)
      • metabolism NOS
        • plasma protein NEC
    • Double
      • albumin
    • Dysproteinemia
    • Hyperproteinemia
    • Hypoalbuminemia
    • Inversion
      • albumin-globulin (A-G) ratio
    • Para-albuminemia
    • Pyroglobulinemia NEC

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hypoalbuminemia

    a condition in which albumin level in blood (serum albumin) is below the normal range. hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (albuminuria).

  • Hypoproteinemia

    a condition in which total serum protein level is below the normal range. hypoproteinemia can be caused by protein malabsorption in the gastrointestinal tract, edema, or proteinuria.

  • Protein-Losing Enteropathies

    pathological conditions in the intestines that are characterized by the gastrointestinal loss of serum proteins, including serum albumin; immunoglobulins; and at times lymphocytes. severe condition can result in hypogammaglobulinemia or lymphopenia. protein-losing enteropathies are associated with a number of diseases including intestinal lymphangiectasis; whipple's disease; and neoplasms of the small intestine.

  • Grade 1 Hypoalbuminemia, CTCAE|Grade 1 Hypoalbuminemia

  • Grade 2 Hypoalbuminemia, CTCAE|Grade 2 Hypoalbuminemia

    <3 - 2 g/dl; <30 - 20 g/l

  • APTX wt Allele|AOA|AOA1|AXA1|Aprataxin wt Allele|Ataxia 1, Early Onset With Hypoalbuminemia Gene|EAOH|EOAHA|FHA-HIT

    human aptx wild-type allele is located in the vicinity of 9p21.1 and is approximately 139 kb in length. this allele, which encodes aprataxin protein, is involved in dna repair. mutation of the gene is associated with ataxia-ocular apraxia type 1.

  • Ataxia-Oculomotor Apraxia Type 1|AOA1|Ataxia, Early-Onset, with Oculomotor Apraxia and Hypoalbuminemia|EAOH

    an autosomal recessive cerebellar ataxia caused by mutation(s) in the aptx gene, encoding aprataxin. it is characterized by peripheral axonal neuropathy, oculomotor apraxia, and hypoalbuminemia.

  • Grade 1 Hypoalbuminemia, CTCAE|Grade 1 Hypoalbuminemia

  • Grade 2 Hypoalbuminemia, CTCAE|Grade 2 Hypoalbuminemia

    <3-2 g/dl; <30-20 g/l

  • Grade 3 Hypoalbuminemia, CTCAE|Grade 3 Hypoalbuminemia

    <2 g/dl; <20 g/l

  • Grade 4 Hypoalbuminemia, CTCAE|Grade 4 Hypoalbuminemia

    life-threatening consequences; urgent intervention indicated

  • Grade 5 Hypoalbuminemia, CTCAE|Grade 5 Hypoalbuminemia

    death

  • Hypoalbuminemia

    concentration of serum albumin below normal limits for the age related normal range.

  • Hypoalbuminemia, CTCAE|Hypoalbuminemia|Hypoalbuminemia

    a disorder characterized by laboratory test results that indicate a low concentration of albumin in the blood.

  • Analbuminemia

    a rare, autosomal recessive inherited disorder characterized by the absence or severe reduction of circulating human serum albumin.

  • Hypoproteinemia

    a laboratory test result indicating abnormally low levels of total protein in the serum.

Patient EducationClinical

Metabolic Disorders

Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E88.09 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
273.8 Dis plas protein met NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E88.09Overview

Is E88.09 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other disorders of plasma-protein metabolism, not elsewhere classified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E88.09 group to?

When other disorders of plasma-protein metabolism, not elsewhere classified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 826, 827, 828, 829, 830, 843, 844, 845, with relative weights from 0.8516 to 4.6778 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E88.09?

Under the General Equivalence Mappings, other disorders of plasma-protein metabolism, not elsewhere classified converts to ICD-9-CM 273.8 (dis plas protein met NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.