2027 ICD-10-CM Diagnosis Code E88.09Other disorders of plasma-protein metabolism, not elsewhere classified
ICD-10-CM Codes›E00–E89›E70-E88›E88
- Billable — Valid for Submission
- Chronic Condition
E88.09 is a billable ICD-10-CM diagnosis code for other disorders of plasma-protein metabolism, not elsewhere classified. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 826 through 830, 843 through 845. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Analbuminemia
- Antichymotrypsin deficiency-alpha-1
- Autosomal variant form of transthyretin
- Bisalbuminemia
- Congenital analbuminemia
- Congenital atransferrinemia
- Congenital transferrin deficiency
- Deficiency of choline esterase II
- Deficiency of inosine nucleosidase
- Disorder of plasma protein metabolism
- Disorder of protein metabolism
- Edema due to hypoproteinemia
- Hereditary butyrylcholinesterase deficiency
- Hyperalbuminemia
- Hyperproteinemia
- Hypoalbuminemia
- Hypoalbuminemia due to protein calorie malnutrition
- Hypoproteinemia
- Macroamylasemia
- Metabolic ascites
- Neuropathy associated with dysproteinemias
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E88.09: its own notes plus those printed at E88.0, E88, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Bisalbuminemia
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- histiocytosis X (chronic) (C96.6)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- disorder of lipoprotein metabolism (E78.-)
- Ehlers-Danlos syndromes (Q79.6-)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- codes for associated conditions
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E88.09, its category, or a range that includes it.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Abnormal, abnormality, abnormalities See Also: Anomaly;
transport protein E88.09
Analbuminemia E88.09
Atransferrinemia, congenital E88.09
Bisalbuminemia E88.09
Disorder (of) See Also: Disease;
Dysproteinemia E88.09
Hyperproteinemia E88.09
Hypoalbuminemia E88.09
Para-albuminemia E88.09
Pyroglobulinemia NEC E88.09
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Hypoalbuminemia
a condition in which albumin level in blood (serum albumin) is below the normal range. hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (albuminuria).
Patient EducationClinical
Metabolic Disorders
Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E88.09 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E88.09Overview
What is the ICD-10 code for other disorders of plasma-protein metabolism, not elsewhere classified?
The ICD-10-CM code for other disorders of plasma-protein metabolism, not elsewhere classified is E88.09 (sometimes written as E8809). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E88.09 a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other disorders of plasma-protein metabolism, not elsewhere classified on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E88.09 group to?
When other disorders of plasma-protein metabolism, not elsewhere classified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 844, 827, 829, 843, 828, 826, 830, 845, with relative weights from 0.8443 to 4.7560 depending on complications. Higher weights mean higher Medicare reimbursement.
Can E88.09 be reported with D47.2?
Not as a rule. The Excludes1 note at E88.0, which applies to E88.09, lists "monoclonal gammopathy (of undetermined significance) (D47.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does E88.09 need an additional code?
When the condition applies, yes. The Use Additional Code note at E88, which applies to E88.09, reads: codes for associated conditions. The additional code is reported after E88.09.
