2027 ICD-10-CM Diagnosis Code E16Other disorders of pancreatic internal secretion

ICD-10-CM Codes›E00–E89›E15-E16›E16

ICD-10-CM E16
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E16 is a non-billable ICD-10-CM category code for other disorders of pancreatic internal secretion, so it cannot be submitted on claims. Use a more specific code from this category instead, such as E16.0, E16.1, E16.2, and E16.3.

Code Identity

ICD-10-CM Code
E16
Billable Status
No — Non-Billable Category
Code Describes
Other disorders of pancreatic internal secretion
Short Description
Other disorders of pancreatic internal secretion
Same as the full description in the CMS dataset.
Chapter
E15-E16
Other disorders of glucose regulation and pancreatic internal secretion

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE15-E16Other disorders of glucose regulation and pancreatic internal secretion
CategoryE16Other disorders of pancreatic internal secretion
This CodeE16Other disorders of pancreatic internal secretion

Specific Coding for Other disorders of pancreatic internal secretionOverview

Non-specific codes like E16 require more characters. Use one of these billable codes instead:

  • Use E16.0 for Drug-induced hypoglycemia without coma

  • Use E16.1 for Other hypoglycemia

  • Use E16.2 for Hypoglycemia, unspecified

  • Use E16.3 for Increased secretion of glucagon

  • Use E16.4 for Increased secretion of gastrin

  • Use E16.8 for Other specified disorders of pancreatic internal secretion

  • Use E16.9 for Disorder of pancreatic internal secretion, unspecified

  • E16.A for Hypoglycemia level

  • Use E16.A1 for Hypoglycemia level 1

  • Use E16.A2 for Hypoglycemia level 2

  • Use E16.A3 for Hypoglycemia level 3

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E16: its own notes plus those printed at Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E16, its category, or a range that includes it.

Code First 1

These codes say to code first a condition named in the note, and E16 is one of the conditions named.

  • G63 Polyneuropathy in diseases classified elsewhere
    endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34) names E15-E16, which includes this code

Notes 1

These notes mention E16.

  • Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases
    All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Patient EducationClinical

Pancreatic Diseases

The pancreas is a gland behind your stomach and in front of your spine. It produces juices that help break down food and hormones that help control blood sugar levels. Problems with the pancreas can lead to many health problems. These include:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E16Overview

What is the ICD-10 code for other disorders of pancreatic internal secretion?

E16 is the ICD-10-CM category for other disorders of pancreatic internal secretion, but it is a non-billable header: claims need a more specific code from this category, listed on this page.

Is E16 (Other disorders of pancreatic internal secretion) a billable code?

No. This is a category header that groups the codes for other disorders of pancreatic internal secretion, and headers cannot be submitted on claims. Claims for other disorders of pancreatic internal secretion need a more specific code from this category, such as E16.0, E16.1, and E16.2.