Neoplasms (C00–D49)
ICD-10-CM Chapter 2 includes codes C00-D49, which cover a wide range of neoplasms, both benign and malignant. These codes are used to classify tumors based on their nature and location in the body.
This chapter focuses on diagnosing and categorizing various tumor types, including cancers and non-cancerous growths. Malignant neoplasms, or cancers, are coded from C00 to C97 and represent uncontrolled cell growth that can invade or spread. Codes D00 to D49 cover in situ tumors, benign tumors, and neoplasms of uncertain or unknown behavior. This classification helps healthcare professionals identify the exact type and behavior of a tumor, essential for treatment planning and medical record documentation. The codes also specify tumor sites like the skin, respiratory system, digestive organs, and more, supporting precise diagnosis and reporting.
- Malignant neoplasms of lip, oral cavity and pharynx (C00-C14
- Malignant neoplasms of digestive organs (C15-C26)
- Malignant neoplasms of respiratory and intrathoracic organs
- Malignant neoplasms of bone and articular cartilage (C40-C41
- Melanoma and other malignant neoplasms of skin (C43-C44)
- Malignant neoplasms of mesothelial and soft tissue (C45-C49)
- Malignant neoplasms of breast (C50)
- Malignant neoplasms of female genital organs (C51-C58)
- Malignant neoplasms of male genital organs (C60-C63)
- Malignant neoplasms of urinary tract (C64-C68)
- Malignant neoplasms of eye, brain and other parts of central
- Malignant neoplasms of thyroid and other endocrine glands (C
- Malignant neuroendocrine tumors (C7A)
- Secondary neuroendocrine tumors (C7B)
- Malignant neoplasms of ill-defined, other secondary and unsp
- Malignant neoplasms of lymphoid, hematopoietic and related t
- In situ neoplasms (D00-D09)
- Benign neoplasms, except benign neuroendocrine tumors (D10-D
- Benign neuroendocrine tumors (D3A)
- Neoplasms of uncertain behavior, polycythemia vera and myelo
- Neoplasms of unspecified behavior (D49)
Neoplasms (C00–D49)
Note: Functional activity
All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
Morphology [Histology]
Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
Primary malignant neoplasms overlapping site boundaries
A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
Malignant neoplasm of ectopic tissue
Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).Malignant neoplasms of lip, oral cavity and pharynx (C00-C14)
- Malignant neoplasm of lip (C00)
- Malignant neoplasm of base of tongue (C01)
- Malignant neoplasm of other and unspecified parts of tongue (C02)
- Malignant neoplasm of gum (C03)
- Malignant neoplasm of floor of mouth (C04)
- Malignant neoplasm of palate (C05)
- Malignant neoplasm of other and unspecified parts of mouth (C06)
- Malignant neoplasm of parotid gland (C07)
- Malignant neoplasm of other and unspecified major salivary glands (C08)
- Malignant neoplasm of tonsil (C09)
- Malignant neoplasm of oropharynx (C10)
- Malignant neoplasm of nasopharynx (C11)
- Malignant neoplasm of pyriform sinus (C12)
- Malignant neoplasm of hypopharynx (C13)
- Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx (C14)
Malignant neoplasms of digestive organs (C15-C26)
- Malignant neoplasm of esophagus (C15)
- Malignant neoplasm of stomach (C16)
- Malignant neoplasm of small intestine (C17)
- Malignant neoplasm of colon (C18)
- Malignant neoplasm of rectosigmoid junction (C19)
- Malignant neoplasm of rectum (C20)
- Malignant neoplasm of anus and anal canal (C21)
- Malignant neoplasm of liver and intrahepatic bile ducts (C22)
- Malignant neoplasm of gallbladder (C23)
- Malignant neoplasm of other and unspecified parts of biliary tract (C24)
- Malignant neoplasm of pancreas (C25)
- Malignant neoplasm of other and ill-defined digestive organs (C26)
Malignant neoplasms of respiratory and intrathoracic organs (C30-C39)
- Malignant neoplasm of nasal cavity and middle ear (C30)
- Malignant neoplasm of accessory sinuses (C31)
- Malignant neoplasm of larynx (C32)
- Malignant neoplasm of trachea (C33)
- Malignant neoplasm of bronchus and lung (C34)
- Malignant neoplasm of thymus (C37)
- Malignant neoplasm of heart, mediastinum and pleura (C38)
- Malignant neoplasm of other and ill-defined sites in the respiratory system and intrathoracic organs (C39)
Malignant neoplasms of bone and articular cartilage (C40-C41)
Melanoma and other malignant neoplasms of skin (C43-C44)
Malignant neoplasms of mesothelial and soft tissue (C45-C49)
Malignant neoplasms of breast (C50)
- Malignant neoplasm of breast (C50)
Malignant neoplasms of female genital organs (C51-C58)
- Malignant neoplasm of vulva (C51)
- Malignant neoplasm of vagina (C52)
- Malignant neoplasm of cervix uteri (C53)
- Malignant neoplasm of corpus uteri (C54)
- Malignant neoplasm of uterus, part unspecified (C55)
- Malignant neoplasm of ovary (C56)
- Malignant neoplasm of other and unspecified female genital organs (C57)
- Malignant neoplasm of placenta (C58)
Malignant neoplasms of male genital organs (C60-C63)
Malignant neoplasms of urinary tract (C64-C68)
Malignant neoplasms of eye, brain and other parts of central nervous system (C69-C72)
Malignant neoplasms of thyroid and other endocrine glands (C73-C75)
Malignant neuroendocrine tumors (C7A)
- Malignant neuroendocrine tumors (C7A)
Secondary neuroendocrine tumors (C7B)
- Secondary neuroendocrine tumors (C7B)
Malignant neoplasms of ill-defined, other secondary and unspecified sites (C76-C80)
- Malignant neoplasm of other and ill-defined sites (C76)
- Secondary and unspecified malignant neoplasm of lymph nodes (C77)
- Secondary malignant neoplasm of respiratory and digestive organs (C78)
- Secondary malignant neoplasm of other and unspecified sites (C79)
- Malignant neoplasm without specification of site (C80)
Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96)
- Hodgkin lymphoma (C81)
- Follicular lymphoma (C82)
- Non-follicular lymphoma (C83)
- Mature T/NK-cell lymphomas (C84)
- Other specified and unspecified types of non-Hodgkin lymphoma (C85)
- Other specified types of T/NK-cell lymphoma (C86)
- Malignant immunoproliferative diseases and certain other B-cell lymphomas (C88)
- Multiple myeloma and malignant plasma cell neoplasms (C90)
- Lymphoid leukemia (C91)
- Myeloid leukemia (C92)
- Monocytic leukemia (C93)
- Other leukemias of specified cell type (C94)
- Leukemia of unspecified cell type (C95)
- Other and unspecified malignant neoplasms of lymphoid, hematopoietic and related tissue (C96)
In situ neoplasms (D00-D09)
- Carcinoma in situ of oral cavity, esophagus and stomach (D00)
- Carcinoma in situ of other and unspecified digestive organs (D01)
- Carcinoma in situ of middle ear and respiratory system (D02)
- Melanoma in situ (D03)
- Carcinoma in situ of skin (D04)
- Carcinoma in situ of breast (D05)
- Carcinoma in situ of cervix uteri (D06)
- Carcinoma in situ of other and unspecified genital organs (D07)
- Carcinoma in situ of other and unspecified sites (D09)
Benign neoplasms, except benign neuroendocrine tumors (D10-D36)
- Benign neoplasm of mouth and pharynx (D10)
- Benign neoplasm of major salivary glands (D11)
- Benign neoplasm of colon, rectum, anus and anal canal (D12)
- Benign neoplasm of other and ill-defined parts of digestive system (D13)
- Benign neoplasm of middle ear and respiratory system (D14)
- Benign neoplasm of other and unspecified intrathoracic organs (D15)
- Benign neoplasm of bone and articular cartilage (D16)
- Benign lipomatous neoplasm (D17)
- Hemangioma and lymphangioma, any site (D18)
- Benign neoplasm of mesothelial tissue (D19)
- Benign neoplasm of soft tissue of retroperitoneum and peritoneum (D20)
- Other benign neoplasms of connective and other soft tissue (D21)
- Melanocytic nevi (D22)
- Other benign neoplasms of skin (D23)
- Benign neoplasm of breast (D24)
- Leiomyoma of uterus (D25)
- Other benign neoplasms of uterus (D26)
- Benign neoplasm of ovary (D27)
- Benign neoplasm of other and unspecified female genital organs (D28)
- Benign neoplasm of male genital organs (D29)
- Benign neoplasm of urinary organs (D30)
- Benign neoplasm of eye and adnexa (D31)
- Benign neoplasm of meninges (D32)
- Benign neoplasm of brain and other parts of central nervous system (D33)
- Benign neoplasm of thyroid gland (D34)
- Benign neoplasm of other and unspecified endocrine glands (D35)
- Benign neoplasm of other and unspecified sites (D36)
Benign neuroendocrine tumors (D3A)
- Benign neuroendocrine tumors (D3A)
Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48)
- Neoplasm of uncertain behavior of oral cavity and digestive organs (D37)
- Neoplasm of uncertain behavior of middle ear and respiratory and intrathoracic organs (D38)
- Neoplasm of uncertain behavior of female genital organs (D39)
- Neoplasm of uncertain behavior of male genital organs (D40)
- Neoplasm of uncertain behavior of urinary organs (D41)
- Neoplasm of uncertain behavior of meninges (D42)
- Neoplasm of uncertain behavior of brain and central nervous system (D43)
- Neoplasm of uncertain behavior of endocrine glands (D44)
- Polycythemia vera (D45)
- Myelodysplastic syndromes (D46)
- Other neoplasms of uncertain behavior of lymphoid, hematopoietic and related tissue (D47)
- Neoplasm of uncertain behavior of other and unspecified sites (D48)
Neoplasms of unspecified behavior (D49)
- Neoplasms of unspecified behavior (D49)
