Other disorders of glucose regulation and pancreatic internal secretion (E15-E16) ICD-10-CM
The E15–E16 section covers other disorders of glucose regulation and pancreatic internal secretion with 13 ICD-10-CM diagnosis codes, of which 11 are billable in fiscal year 2026. The section is organized into the 2 code ranges listed below.
Code Ranges in This Section 2 ranges · 13 codes
| Code Range | Title | Codes | Billable |
|---|---|---|---|
| E15 | Nondiabetic hypoglycemic coma (E15) | 1 | 1 |
| E16 | Other disorders of pancreatic internal secretion (E16) | 12 | 10 |
The info icon previews the code ranges inside each row and its instructional notations from the official Tabular List.
About the E15–E16 Code Range
ICD-10 codes E15 through E16 cover uncommon but important disorders related to abnormal glucose levels and pancreatic hormone secretion that are not caused by diabetes. These include various types of hypoglycemia (low blood sugar) and other problems involving the pancreas’ hormone production, such as excess glucagon or gastrin.
This range specifically codes for conditions like E15 Nondiabetic hypoglycemic coma, also known as insulin coma or drug-induced coma, which is a serious state caused by very low blood sugar unrelated to diabetes. Codes starting with E16 address other pancreatic hormone issues including E16.0 Drug-induced hypoglycemia without coma (also called iatrogenic hypoglycemia), E16.1 Other hypoglycemia which covers functional or familial hyperinsulinism and reactive hypoglycemia, and E16.3 and E16.4 for increased secretion of glucagon and gastrin hormones respectively. These codes assist health professionals in accurately identifying non-diabetic endocrine disorders like Zollinger-Ellison syndrome (gastrinoma), impaired glucose tolerance with hyperinsulinism, and other hormone secretion abnormalities. The unspecified and “other” categories (E16.2, E16.8, E16.9) allow coding for less defined pancreatic secretion disorders or hypoglycemia levels, helping capture a full spectrum of endocrine pancreatic conditions essential for diagnosis and treatment planning.
Questions About This Page
How many codes are in the E15-E16 range?
The E15-E16 range contains 13 ICD-10-CM diagnosis codes in FY 2026. 11 of them are billable, and the rest are category headers that organize the section.
What conditions does E15-E16 cover?
The range covers other disorders of glucose regulation and pancreatic internal secretion. The code ranges listed above break it into groups of related conditions, and each one links to its own page with the full code list.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
