Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89) ICD-10-CM
Chapter 3 of the ICD-10-CM classification spans codes D50–D89 and contains 401 diagnosis codes for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism, of which 323 are billable. The chapter is organized into 7 sections listed below, each linking to its code ranges and individual codes.
Chapter Coding Notes
Excludes2: autoimmune disease (systemic) NOS (M35.9), certain conditions originating in the perinatal period (P00-P96), complications of pregnancy, childbirth and the puerperium (O00-O9A), congenital malformations, deformations and chromosomal abnormalities (Q00-Q99), endocrine, nutritional and metabolic diseases (E00-E88), human immunodeficiency virus [HIV] disease (B20) injury, poisoning and certain other consequences of external causes (S00-T88), neoplasms (C00-D49) symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Sections in This Chapter 7 ranges · 401 codes
The info icon previews the code ranges inside each row and its instructional notations from the official Tabular List.
About Chapter 3
ICD-10-CM Chapter 3 covers conditions related to the blood, blood-forming organs, and immune system disorders. It includes codes for anemia, coagulation defects, and immunodeficiencies.
This chapter encompasses a wide range of disorders affecting how blood cells develop and function, including various types of anemia such as iron-deficiency or hemolytic anemia. It also addresses coagulation defects that impact blood clotting processes, leading to bleeding or clotting issues. Additionally, codes in this range represent immune system disorders where the body's defense mechanisms are weakened or abnormal, such as immunodeficiencies or autoimmune conditions. Healthcare providers use these codes to document diagnoses related to blood abnormalities and immune dysfunctions accurately. This ensures clear communication for treatment planning, insurance claims, and epidemiological tracking of these diseases.
Questions About This Page
How many codes are in the D50-D89 range?
The D50-D89 range contains 401 ICD-10-CM diagnosis codes in FY 2026. 323 of them are billable, and the rest are category headers that organize the chapter.
What conditions does D50-D89 cover?
The range covers diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism. The sections listed above break it into groups of related conditions, and each one links to its own page with the full code list.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
