Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89) ICD-10-CM
Chapter 3 of the ICD-10-CM classification spans codes D50–D89 and contains 403 diagnosis codes for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism, of which 324 are billable. The chapter is organized into 7 sections listed below, each linking to its code ranges and individual codes.
Chapter Coding Notes
Excludes2: autoimmune disease (systemic) NOS (M35.9), certain conditions originating in the perinatal period (P00-P96), complications of pregnancy, childbirth and the puerperium (O00-O9A), congenital malformations, deformations and chromosomal abnormalities (Q00-Q99), endocrine, nutritional and metabolic diseases (E00-E88), human immunodeficiency virus [HIV] disease (B20) injury, poisoning and certain other consequences of external causes (S00-T88), neoplasms (C00-D49) symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Sections in This Chapter 7 ranges · 403 codes
The info icon previews the code ranges inside each row and its instructional notations from the official Tabular List.
About Chapter 3
These conditions affect the blood, the organs that form it, or certain parts of the immune system.
The blocks separate nutritional, hemolytic, and aplastic or other anemias. Bone marrow failure syndromes appear with aplastic and other anemias. The remaining blocks group clotting defects and bleeding conditions, other blood and blood-forming organ disorders, spleen complications during or after procedures, and immune system disorders.
FY 2027 changes: The FY 2027 ICD-10-CM update, effective October 1, 2026, added 2 codes and deleted 2 codes in this chapter.
Questions About This Page
How many codes are in the D50-D89 range?
The D50-D89 range contains 403 ICD-10-CM diagnosis codes in FY 2027. 324 of them are billable, and the rest are category headers that organize the chapter.
What conditions does D50-D89 cover?
The range covers diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism. The sections listed above break it into groups of related conditions, and each one links to its own page with the full code list.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
