2027 ICD-10-CM Diagnosis Code E23.0Hypopituitarism

ICD-10-CM Codes›E00–E89›E20-E35›E23

ICD-10-CM E23.0
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E23.0 is a billable ICD-10-CM diagnosis code for hypopituitarism. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 21 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Pituitary disorders.

E23.0 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.

Code Identity

ICD-10-CM Code
E23.0
Billable Status
Yes — Valid for Submission
Code Describes
Hypopituitarism
Short Description
Hypopituitarism
Same as the full description in the CMS dataset.
Parent Code
E23
Hypofunction and other disorders of the pituitary gland

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE23Hypofunction and other disorders of the pituitary gland
This CodeE23.0Hypopituitarism

Medicare Risk Adjustment (HCC)Billing

E23.0 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
Dropped in V28 see all codes that no longer risk-adjust
Prior Model (CMS-HCC V24)
HCC 23
V24 retired last contributed to a Medicare Advantage risk score in payment year 2025
Other CMS Models
PACE (CMS-HCC V22): HCC 23 · ESRD (V21): HCC 23 · ESRD (V24): HCC 23
ESRD V21 weights: 0.013 dialysis, 0.234–0.359 functioning graft · ESRD V24 weights: 0.036 dialysis, 0.217–0.390 functioning graft
Part D (RxHCC)
RxHCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired central hypothyroidism
  • Acquired central hypothyroidism due to pituitary disorder
  • Acquired central hypothyroidism due to Sheehan syndrome
  • ACTH deficiency
  • Adult growth hormone deficiency
  • Adult growth hormone deficiency with onset in childhood
  • Adult-onset growth hormone deficiency
  • Alopecia and intellectual disability with hypergonadotropic hypogonadism syndrome
  • Amenorrhea due to congenital gonadotrophin releasing hormone deficiency
  • Anemia of endocrine disorder
  • Anemia of pituitary deficiency
  • Anterior pituitary hormone deficiency
  • Asexual dwarfism
  • Ateleiotic dwarfism
  • Ateliotic dwarfism without insulinopenia
  • Autoimmune hypopituitarism
  • Autosomal dominant isolated somatotropin deficiency
  • Autosomal recessive isolated somatotropin deficiency
  • Avascular necrosis of pituitary gland
  • Cataract, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, skeletal dysplasia syndrome
  • Central hypothyroidism
  • Combined pituitary hormone deficiency genetic form
  • Congenital disorder of facial nerve
  • Congenital facial nerve palsy
  • Congenital hypogonadotropic hypogonadism
  • Congenital hypoplasia of nose
  • Congenital malformation of anterior pituitary
  • Congenital stenosis of carotid artery
  • Deficiency in anterior pituitary function, variable immunodeficiency syndrome
  • Endocrine myopathy
  • Female hypogonadotropic hypogonadism
  • Female infertility of pituitary - hypothalamic origin
  • Follicle stimulating hormone deficiency
  • Functional hypogonadotropic hypogonadism
  • Gonadotropin releasing factor deficiency
  • Growth hormone deficiency
  • Growth hormone deficiency after bone marrow transplant
  • Growth hormone neurosecretory dysfunction
  • Hereditary growth hormone deficiency
  • Hereditary sensory neuropathy
  • Hypergonadotropic hypogonadism with cataract syndrome
  • Hypogonadism with anosmia
  • Hypogonadotropic hypogonadism
  • Hypogonadotropic hypogonadism due to follicle-stimulating hormone deficiency
  • Hypogonadotropic hypogonadism due to isolated gonadotropin deficiency
  • Hypogonadotropic hypogonadism due to luteinizing hormone deficiency
  • Hypogonadotropic hypogonadism retinitis pigmentosa syndrome
  • Hypogonadotropic hypogonadism with frontoparietal alopecia syndrome
  • Hypogonadotropic hypogonadism, severe microcephaly, sensorineural hearing loss, dysmorphism syndrome
  • Hypopituitarism
  • Hypopituitarism due to granulomatous disease
  • Hypopituitarism due to metabolic disease
  • Hypopituitarism due to pituitary neoplasm
  • Hypopituitarism due to vascular disorder
  • Hypopituitarism following procedure
  • Hypoplasia of eye
  • Hyposmia, nasal and ocular hypoplasia, hypogonadotropic hypogonadism syndrome
  • Hypothyrotropic hypothyroidism
  • Idiopathic growth hormone deficiency
  • Idiopathic hypogonadotropic hypogonadism
  • Idiopathic hypopituitarism
  • Idiopathic panhypopituitarism
  • Immunodeficiency associated with multiple organ system abnormalities
  • Immunodeficiency with major anomalies
  • Immunoglobulinemia with isolated somatotropin deficiency
  • Internal carotid artery stenosis
  • Isolated follicle stimulating hormone deficiency
  • Isolated gonadotropin deficiency
  • Isolated lutropin deficiency
  • Isolated pituitary hormone deficiency
  • Isolated prolactin deficiency
  • Isolated somatotropin deficiency
  • Kallman syndrome with heart disease
  • Late-onset isolated adrenocorticotropic hormone deficiency
  • LH - luteinizing hormone deficiency
  • Loss of sense of smell
  • Lymphocytic hypopituitarism
  • Male hypergonadotropic hypogonadism, intellectual disability, skeletal anomaly syndrome
  • Martsolf syndrome
  • Microcephalus, hypergonadotropic hypogonadism, short stature syndrome
  • Moebius syndrome, axonal neuropathy, hypogonadotropic hypogonadism syndrome
  • Morbid obesity
  • Moyamoya angiopathy, short stature, facial dysmorphism, hypergonadotropic hypogonadism syndrome
  • Moyamoya disease
  • Myopathy in hypopituitarism
  • Necrosis of pituitary
  • Non-acquired combined pituitary hormone deficiency, sensorineural hearing loss, spine abnormalities syndrome
  • Nonfamilial asexual dwarfism
  • Nonfamilial hyperinsulinemic isolated somatotropin deficiency
  • Panhypopituitarism
  • Panhypopituitarism - anterior and posterior
  • Partial growth hormone deficiency
  • Partial hypopituitarism
  • Partial loss of hair
  • Peripheral axonal neuropathy
  • Pituitary cachexia
  • Pituitary deficiency due to empty sella turcica syndrome
  • Pituitary dwarfism
  • Pituitary dwarfism with large sella turcica
  • Pituitary dwarfism with normal somatotropin level AND low somatomedin
  • Pituitary dwarfism with small sella turcica
  • Post-birth injury hypopituitarism
  • Post-infarction hypopituitarism
  • Post-infarction panhypopituitarism
  • Post-infective hypopituitarism
  • Postpartum hypopituitarism
  • Post-traumatic hypopituitarism
  • Prepuberal panhypopituitarism
  • Primary hypergonadotropic hypogonadism and partial alopecia syndrome
  • Primary pituitary - hypothalamic infertility
  • Primary testicular failure
  • Proopiomelanocortin deficiency syndrome
  • Psychosocial growth hormone deficiency
  • RAB18 deficiency
  • RHYNS syndrome
  • Secondary hypopituitarism
  • Secondary pituitary - hypothalamic infertility
  • Sequelae of endocrine disorders
  • Sheehan's syndrome
  • Short stature co-occurrent and due to endocrine disorder
  • Stenosis of intracranial carotid artery
  • Transient somatotropin deficiency
  • X-linked panhypopituitarism

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E23.0: its own notes plus those printed at E23, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From E23 Hypofunction and other disorders of the pituitary gland applies to 6 codes
  • the listed conditions whether the disorder is in the pituitary or the hypothalamus

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Fertile eunuch syndrome
  • Hypogonadotropic hypogonadism
  • Idiopathic growth hormone deficiency
  • Isolated deficiency of gonadotropin
  • Isolated deficiency of growth hormone
  • Isolated deficiency of pituitary hormone
  • Kallmann's syndrome
  • Lorain-Levi short stature
  • Necrosis of pituitary gland (postpartum)
  • Panhypopituitarism
  • Pituitary cachexia
  • Pituitary insufficiency NOS
  • Pituitary short stature
  • Sheehan's syndrome
  • Simmonds' disease

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E23 Hypofunction and other disorders of the pituitary gland applies to 6 codes
  • postprocedural hypopituitarism (E89.3)
  • short stature due to endocrine disorder (E34.3-)
From Block E20-E35 Disorders of other endocrine glands applies to 99 codes
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

  • code, if applicable, for associated cachexia (E88.A)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E23.0, its category, or a range that includes it.

Excludes1 4

These codes carry an Excludes1 note naming E23.0: they are not reported together with it, unless the two conditions are unrelated.

  • E28 Ovarian dysfunction
    isolated gonadotropin deficiency (E23.0)
  • E29 Testicular dysfunction
    isolated gonadotropin deficiency (E23.0)
  • E34.3 Short stature due to endocrine disorder
    pituitary short stature (E23.0)
  • R62 Lack of expected normal physiological development in childhood and adults
    hypopituitarism (E23.0)

Excludes2 2

These codes carry an Excludes2 note naming E23.0: its condition is not part of those codes, and both may be reported when the patient has both.

  • N97 Female infertility
    hypopituitarism (E23.0)
  • Chapter 15 (O00-O9A) Pregnancy, childbirth and the puerperium
    postpartum necrosis of pituitary gland (E23.0)

Code First 1

These codes say to code first a condition named in the note, and E23.0 is one of the conditions named.

  • G63 Polyneuropathy in diseases classified elsewhere
    endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34) names E20-E34, which includes this code

Notes 1

These notes mention E23.0.

  • Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases
    All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END013
Pituitary disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hypopituitarism

    diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including lh; follicle stimulating hormone; somatotropin; and corticotropin). this may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.

Patient EducationClinical

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E23.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
253.2 Panhypopituitarism
Approximate The match is approximate rather than exact.
ICD-9-CM
253.3 Pituitary dwarfism
Approximate The match is approximate rather than exact.
ICD-9-CM
628.1 Infertil-pituitary orig
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E23.0Overview

What is the ICD-10 code for hypopituitarism?

The ICD-10-CM code for hypopituitarism is E23.0 (sometimes written as E230). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E23.0 (Hypofunction and other disorders of the pituitary gland) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hypopituitarism on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E23.0 group to?

When hypopituitarism is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.

Is E23.0 a CC or MCC?

CMS lists E23.0 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 21 closely related codes in its exclusion list.

Can E23.0 be reported with E89.3?

Not as a rule. The Excludes1 note at E23, which applies to E23.0, lists "postprocedural hypopituitarism (E89.3)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does E23.0 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage. E23.0 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).