2026 ICD-10-CM Diagnosis Code E23.0Hypopituitarism

ICD-10-CM Codes›E00–E89›E20-E35›E23

ICD-10-CM E23.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E23.0 is a billable ICD-10-CM diagnosis code for hypopituitarism. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Pituitary disorders.

Code Identity

ICD-10-CM Code
E23.0
Billable Status
Yes — Valid for Submission
Code Describes
Hypopituitarism
Short Description
Hypopituitarism
Same as the full description in the CMS dataset.
Parent Code
E23
Hypofunction and other disorders of the pituitary gland

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE23Hypofunction and other disorders of the pituitary gland
This CodeE23.0Hypopituitarism

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired central hypothyroidism
  • Acquired central hypothyroidism due to pituitary disorder
  • Acquired central hypothyroidism due to Sheehan syndrome
  • ACTH deficiency
  • Adult growth hormone deficiency
  • Adult growth hormone deficiency with onset in childhood
  • Adult-onset growth hormone deficiency
  • Alopecia and intellectual disability with hypergonadotropic hypogonadism syndrome
  • Amenorrhea due to congenital gonadotrophin releasing hormone deficiency
  • Anemia of endocrine disorder
  • Anemia of pituitary deficiency
  • Anterior pituitary hormone deficiency
  • Asexual dwarfism
  • Ateleiotic dwarfism
  • Ateliotic dwarfism without insulinopenia
  • Autoimmune hypopituitarism
  • Autosomal dominant isolated somatotropin deficiency
  • Autosomal recessive isolated somatotropin deficiency
  • Avascular necrosis of pituitary gland
  • Axonal neuropathy
  • Body height below reference range
  • Cataract, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, skeletal dysplasia syndrome
  • Central hypothyroidism
  • Combined pituitary hormone deficiency genetic form
  • Congenital disorder of facial nerve
  • Congenital facial nerve palsy
  • Congenital hypogonadotropic hypogonadism
  • Congenital hypoplasia of nose
  • Congenital malformation of anterior pituitary
  • Congenital stenosis of carotid artery
  • Deficiency in anterior pituitary function, variable immunodeficiency syndrome
  • Dilated cardiomyopathy with hypergonadotropic hypogonadism syndrome
  • Endocrine myopathy
  • Female hypogonadotropic hypogonadism
  • Female infertility of pituitary - hypothalamic origin
  • Follicle stimulating hormone deficiency
  • Functional hypogonadotropic hypogonadism
  • Gonadotropin releasing factor deficiency
  • Growth hormone deficiency
  • Growth hormone deficiency after bone marrow transplant
  • Growth hormone neurosecretory dysfunction
  • Hereditary growth hormone deficiency
  • Hereditary sensory neuropathy
  • Hypergonadotropic hypogonadism with cataract syndrome
  • Hypogonadism with anosmia
  • Hypogonadotropic hypogonadism
  • Hypogonadotropic hypogonadism due to follicle-stimulating hormone deficiency
  • Hypogonadotropic hypogonadism due to isolated gonadotropin deficiency
  • Hypogonadotropic hypogonadism due to luteinizing hormone deficiency
  • Hypogonadotropic hypogonadism retinitis pigmentosa syndrome
  • Hypogonadotropic hypogonadism with frontoparietal alopecia syndrome
  • Hypogonadotropic hypogonadism, severe microcephaly, sensorineural hearing loss, dysmorphism syndrome
  • Hypopituitarism
  • Hypopituitarism due to granulomatous disease
  • Hypopituitarism due to metabolic disease
  • Hypopituitarism due to pituitary neoplasm
  • Hypopituitarism due to vascular disorder
  • Hypopituitarism following procedure
  • Hypoplasia of eye
  • Hyposmia, nasal and ocular hypoplasia, hypogonadotropic hypogonadism syndrome
  • Idiopathic growth hormone deficiency
  • Idiopathic hypogonadotropic hypogonadism
  • Idiopathic hypopituitarism
  • Idiopathic panhypopituitarism
  • Immunodeficiency associated with multiple organ system abnormalities
  • Immunodeficiency with major anomalies
  • Immunoglobulinemia with isolated somatotropin deficiency
  • Internal carotid artery stenosis
  • Isolated follicle stimulating hormone deficiency
  • Isolated gonadotropin deficiency
  • Isolated lutropin deficiency
  • Isolated pituitary hormone deficiency
  • Isolated prolactin deficiency
  • Isolated somatotropin deficiency
  • Kallman syndrome with heart disease
  • Late-onset isolated adrenocorticotropic hormone deficiency
  • LH - luteinizing hormone deficiency
  • Loss of sense of smell
  • Lymphocytic hypopituitarism
  • Male hypergonadotropic hypogonadism, intellectual disability, skeletal anomaly syndrome
  • Martsolf syndrome
  • Microcephalus, hypergonadotropic hypogonadism, short stature syndrome
  • Moebius syndrome, axonal neuropathy, hypogonadotropic hypogonadism syndrome
  • Morbid obesity
  • Moyamoya angiopathy, short stature, facial dysmorphism, hypergonadotropic hypogonadism syndrome
  • Moyamoya disease
  • Myopathy in hypopituitarism
  • Necrosis of pituitary
  • Non-acquired combined pituitary hormone deficiency, sensorineural hearing loss, spine abnormalities syndrome
  • Nonfamilial asexual dwarfism
  • Nonfamilial hyperinsulinemic isolated somatotropin deficiency
  • Panhypopituitarism
  • Panhypopituitarism - anterior and posterior
  • Partial growth hormone deficiency
  • Partial hypopituitarism
  • Partial loss of hair
  • Peripheral axonal neuropathy
  • Pituitary cachexia
  • Pituitary deficiency due to empty sella turcica syndrome
  • Pituitary dwarfism
  • Pituitary dwarfism with large sella turcica
  • Pituitary dwarfism with normal somatotropin level AND low somatomedin
  • Pituitary dwarfism with small sella turcica
  • Post-birth injury hypopituitarism
  • Post-infarction hypopituitarism
  • Post-infarction panhypopituitarism
  • Post-infective hypopituitarism
  • Postpartum hypopituitarism
  • Post-traumatic hypopituitarism
  • Prepuberal panhypopituitarism
  • Primary hypergonadotropic hypogonadism and partial alopecia syndrome
  • Primary pituitary - hypothalamic infertility
  • Primary testicular failure
  • Proopiomelanocortin deficiency syndrome
  • Psychosocial growth hormone deficiency
  • RAB18 deficiency
  • RHYNS syndrome
  • Secondary hypopituitarism
  • Secondary pituitary - hypothalamic infertility
  • Sensory neuropathy
  • Sequelae of endocrine disorders
  • Sheehan's syndrome
  • Short stature co-occurrent and due to endocrine disorder
  • Stenosis of intracranial carotid artery
  • Transient somatotropin deficiency
  • X-linked panhypopituitarism

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Fertile eunuch syndrome
  • Hypogonadotropic hypogonadism
  • Idiopathic growth hormone deficiency
  • Isolated deficiency of gonadotropin
  • Isolated deficiency of growth hormone
  • Isolated deficiency of pituitary hormone
  • Kallmann's syndrome
  • Lorain-Levi short stature
  • Necrosis of pituitary gland (postpartum)
  • Panhypopituitarism
  • Pituitary cachexia
  • Pituitary insufficiency NOS
  • Pituitary short stature
  • Sheehan's syndrome
  • Simmonds' disease

Use Additional Code

  • code, if applicable, for associated cachexia E88.A

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Ahumada-del Castillo syndrome
    • Brissaud's
      • infantilism or dwarfism
    • Cachexia
      • hypophyseal
    • Cachexia
      • hypopituitary
    • Cachexia
      • pituitary
    • Cachexia
      • Simmonds'
    • Decrease(d)
      • function
        • ovary in hypopituitarism
    • Decrease(d)
      • function
        • pituitary (gland) (anterior) (lobe)
    • Decrease(d)
      • function
        • pituitary (gland) (anterior) (lobe)
          • posterior (lobe)
    • Deficiency, deficient
      • gonadotropin (isolated)
    • Deficiency, deficient
      • growth hormone (idiopathic) (isolated)
    • Deficiency, deficient
      • hormone
        • anterior pituitary (partial) NEC
    • Deficiency, deficient
      • hormone
        • anterior pituitary (partial) NEC
          • growth
    • Deficiency, deficient
      • hormone
        • growth (isolated)
    • Deficiency, deficient
      • hormone
        • pituitary
    • Deficiency, deficient
      • pituitary hormone (isolated)
    • Dwarfism
      • hypophyseal
    • Dwarfism
      • Lorain (-Levi) type
    • Dwarfism
      • pituitary
    • Eunuchoidism
      • hypogonadotropic
    • Fertile eunuch syndrome
    • Hypoadrenocorticism
      • pituitary
    • Hypofunction
      • pituitary (gland) (anterior)
    • Hypogonadism
      • hypogonadotropic
    • Hypogonadism
      • pituitary
    • Hypophyseal, hypophysis
      • dwarfism
    • Hypopituitarism(juvenile)
    • Hyposecretion
      • ACTH
    • Infancy, infantile, infantilism
      • Lorain
    • Infancy, infantile, infantilism
      • pituitary
    • Infertility
      • female
        • associated with
          • pituitary-hypothalamic origin
    • Insufficiency, insufficient
      • pituitary
    • Kallmann's syndrome
    • Lorain(-Levi) short stature syndrome
    • Myopathy
      • in (due to)
        • hypopituitarism
    • Necrosis, necrotic(ischemic)
      • pituitary (gland)
    • Panhypopituitarism
    • Panhypopituitarism
      • prepubertal
    • Sheehan's disease or syndrome
    • Simmonds' cachexia or disease
    • Syndrome
      • fertile eunuch
    • Syndrome
      • hypopituitarism
    • Syndrome
      • infantilism (pituitary)
    • Syndrome
      • postpartum panhypopituitary (Sheehan)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END013
Pituitary disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hypopituitarism

    diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including lh; follicle stimulating hormone; somatotropin; and corticotropin). this may result from surgical or radiation ablation, non-secretory pituitary neoplasms, metastatic tumors, infarction, pituitary apoplexy, infiltrative or granulomatous processes, and other conditions.

  • Moyamoya Disease

    a noninflammatory, progressive occlusion of the intracranial carotid arteries and the formation of netlike collateral arteries arising from the circle of willis. cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. it is characterized by endothelial hyperplasia and fibrosis with thickening of arterial walls. this disease primarily affects children but can also occur in adults.

  • Congenital Facial Nerve Palsy

    partial or complete paralysis of the facial muscles of one side of an individual's face that is present at birth. it is caused by damage to the seventh cranial nerve.

  • Growth Hormone Neurosecretory Dysfunction

    reduced spontaneous secretion of growth hormone with normal range response to growth hormone provocative stimuli.

  • Autoimmune Hypophysitis|Lymphocytic Hypophysitis

    an autoimmune condition affecting the pituitary gland, characterized by lymphocytic infiltration, commonly presenting with pituitary hormone deficiencies.

  • Grade 1 Hypophysitis, CTCAE|Grade 1 Hypophysitis

    asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated

  • Grade 2 Hypophysitis, CTCAE|Grade 2 Hypophysitis

    moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental adl

  • Grade 3 Hypophysitis, CTCAE|Grade 3 Hypophysitis

    severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care adl

  • Grade 4 Hypophysitis, CTCAE|Grade 4 Hypophysitis

    life-threatening consequences; urgent intervention indicated

  • Grade 5 Hypophysitis, CTCAE|Grade 5 Hypophysitis

    death

  • Hypophysitis

    an inflammatory process in the pituitary gland.

  • Hypophysitis, CTCAE|Hypophysitis

    a disorder characterized by inflammation and cellular infiltration of the pituitary gland.

  • Lymphocytic Neurohypophysitis

    an autoimmune condition affecting the posterior pituitary gland, which is characterized by lymphocytic infiltration, and which often presents as diabetes insipidus.

  • Morbid Obesity

    an excess of body weight, normally defined as an individual with a body mass index greater than 35 or a body weight greater than one hundred percent of ideal body weight.

  • Pituitary Dwarfism

    proportionately decreased bodily growth due to failure of the pituitary gland to produce an adequate supply of growth hormone.

  • Acute Motor and Sensory Axonal Neuropathy|Acute Motor And Sensory Axonal Neuropathy|Acute Motor-Sensory Axonal Neuropathy|Acute Motor-Sensory Axonal Neuropathy

    a subtype of guillain-barre syndrome that targets sensory motor axons, and is characterized by acute onset of quadriparesis, distal sensory loss, areflexia, and respiratory insufficiency.

  • Acute Motor Axonal Neuropathy|AMAN

    a subtype of guillain-barre syndrome that targets motor axons, and is characterized by symmetric limb weakness, diffuse areflexia, facial and oropharyngeal muscle weakness, and respiratory insufficiency.

  • Axonal Neuropathy

    any nerve disorder affecting the axon of a nerve.

  • GAN wt Allele|GAN1|Giant Axonal Neuropathy (Gigaxonin) Gene|Gigaxonin wt Allele|KLHL16

    human gan wild-type allele is located in the vicinity of 16q24.1 and is approximately 65 kb in length. this allele, which encodes gigaxonin protein, is involved in both ubiquitination and neurofilament structure. mutation of the gene is associated with giant axonal neuropathy.

  • Giant Axonal Neuropathy

    a rare inherited disorder affecting the neurofilaments. it is caused by mutations in the gan gene. it is characterized by the presence of abnormally large nerve cell axons. signs and symptoms include difficulty walking, sensory disturbances, lack of motor coordination and abnormal reflexes in the limbs.

  • Spinocerebellar Ataxia, Autosomal Recessive, with Axonal Neuropathy 2|AOA2|Ataxia with Oculomotor Apraxia Type 2|SCAN2

    an autosomal recessive condition caused by mutation(s) in the setx gene, encoding probable helicase senataxin. it is characterized by juvenile onset progressive cerebellar ataxia, axonal sensorimotor peripheral neuropathy, and increased concentrations of serum alpha-fetoprotein. oculomotor apraxia is common, but is not always present.

  • Moyamoya Disease

    a rare inherited vascular disorder characterized by constriction of arteries at the base of the brain, resulting in the formation of collateral circulation in order to compensate for the constriction. the name "moyamoya" in japanese means "puff of smoke" and derives from the characteristic radiographic appearance of the collateral vessels.

  • Moyamoya Disease 2|MYMY2

    an autosomally inherited subtype of moyamoya disease often presenting in childhood caused by mutation(s) in the rnf213 gene, encoding e3 ubiquitin-protein ligase rnf213.

  • RNF213 wt Allele|ALK Lymphoma Oligomerization Partner on Chromosome 17 Gene|ALO17|C17orf27|Chromosome 17 Open Reading Frame 27 Gene|DKFZp762N1115|FLJ13051|KIAA1554|KIAA1618|MGC46622|MGC9929|MYMY2|MYSTR|Moyamoya Disease 2 Gene|NET57|Ring Finger Protein 213 wt Allele|hCG_1812857

    human rnf213 wild-type allele is located in the vicinity of 17q25.3 and is approximately 135 kb in length. this allele, which encodes e3 ubiquitin-protein ligase rnf213 protein, may play a role in the regulation of protein ubiquitination. a chromosomal translocation t(2;17)(p23;q25) of this gene with the alk gene is associated with anaplastic large cell lymphoma.

  • Acquired Central Hypothyroidism

    central hypothyroidism, the cause of which is not present at birth.

  • Congenital Hypogonadotropic Hypogonadism

    insufficient production of estrogen or testosterone in the ovaries or testes due to decreased secretion of gonadotropins as a result of pituitary or hypothalamus gland dysfunction that is present at birth.

  • Isolated Follicle Stimulating Hormone Deficiency

    subnormal concentration of follicle stimulating hormone (fsh), associated with mutations in the fshb gene, encoding follitropin subunit beta.

Patient EducationClinical

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E23.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
253.2 Panhypopituitarism
Approximate The match is approximate rather than exact.
ICD-9-CM
253.3 Pituitary dwarfism
Approximate The match is approximate rather than exact.
ICD-9-CM
628.1 Infertil-pituitary orig
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E23.0Overview

Is E23.0 (Hypofunction and other disorders of the pituitary gland) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report hypopituitarism on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E23.0 group to?

When hypopituitarism is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E23.0?

Under the General Equivalence Mappings, hypopituitarism converts to ICD-9-CM 253.2 (panhypopituitarism), 253.3 (pituitary dwarfism), and 628.1 (infertil-pituitary orig). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.