ICD-10-CM Code E22.1


Version 2020 Billable Code

Valid for Submission

E22.1 is a billable code used to specify a medical diagnosis of hyperprolactinemia. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code E22.1 might also be used to specify conditions or terms like drug-induced hyperprolactinemia, familial hyperprolactinemia, hyperprolactinemia, idiopathic hyperprolactinemia, lactation hyperprolactinemia, macroprolactinemia, etc

Short Description:Hyperprolactinemia
Long Description:Hyperprolactinemia

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E22.1:

Use Additional Code

Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
  • code for adverse effect, if applicable, to identify drug T36 T50

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code E22.1 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Drug-induced hyperprolactinemia
  • Familial hyperprolactinemia
  • Hyperprolactinemia
  • Idiopathic hyperprolactinemia
  • Lactation hyperprolactinemia
  • Macroprolactinemia
  • Physiological hyperprolactinemia
  • Physiological hyperprolactinemia
  • Pituitary stalk compression hyperprolactinemia
  • Pregnancy hyperprolactinemia
  • Secondary hyperprolactinemia
  • Secondary hyperprolactinemia
  • Secondary hyperprolactinemia due to prolactin-secreting tumor
  • Transient hyperprolactinemia

Clinical Information

  • HYPERPROLACTINEMIA-. increased levels of prolactin in the blood which may be associated with amenorrhea and galactorrhea. relatively common etiologies include prolactinoma medication effect kidney failure granulomatous diseases of the pituitary gland and disorders which interfere with the hypothalamic inhibition of prolactin release. ectopic non pituitary production of prolactin may also occur. from joynt clinical neurology 1992 ch36 pp77 8

Diagnostic Related Groups

The ICD-10 code E22.1 is grouped in the following groups for version MS-DRG V37.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2020.


Convert E22.1 to ICD-9

  • 253.1 - Ant pituit hyperfunc NEC (Approximate Flag)

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Disorders of other endocrine glands (E20-E35)
      • Hyperfunction of pituitary gland (E22)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

With pituitary disorders, you often have too much or too little of one of your hormones. Injuries can cause pituitary disorders, but the most common cause is a pituitary tumor.

[Learn More]