Hyperfunction of pituitary gland (E22)

• ICD-10 Index

  • Endocrine, nutritional and metabolic diseases (E00–E90)

    • Disorders of other endocrine glands (E20-E35)

      • Hyperfunction of pituitary gland (E22)

        • E22 - Hyperfunction of pituitary gland NON-BILLABLE CODE
        • E22.0 - Acromegaly and pituitary gigantism BILLABLE CODE
        • E22.1 - Hyperprolactinemia BILLABLE CODE
        • E22.2 - Syndrome of inappropriate secretion of antidiuretic hormone BILLABLE CODE
        • E22.8 - Other hyperfunction of pituitary gland BILLABLE CODE
        • E22.9 - Hyperfunction of pituitary gland, unspecified BILLABLE CODE

Clinical Information for Hyperfunction of pituitary gland (E22)

Hyperprolactinemia - Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)

Hyperpituitarism - Disease of the glandular, anterior portion of the pituitary (PITUITARY GLAND, ANTERIOR) resulting in hypersecretion of ADENOHYPOPHYSEAL HORMONES such as GROWTH HORMONE; PROLACTIN; THYROTROPIN; LUTEINIZING HORMONE; FOLLICLE STIMULATING HORMONE ; and ADRENOCORTICOTROPIC HORMONE. Hyperpituitarism usually is caused by a functional ADENOMA.

Acromegaly - A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)

Growth Hormone-Secreting Pituitary Adenoma - A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.

Gigantism - The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.

Sotos Syndrome - Congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.

Instructional Notations

Type 1 Excludes Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

• Cushing's syndrome E24
• Nelson's syndrome E24.1
• overproduction of ACTH not associated with Cushing's disease E27.0
• overproduction of pituitary ACTH E24.0
• overproduction of thyroid-stimulating hormone E05.8