Hyperfunction of pituitary gland (E22)
The E22 ICD-10 code section covers disorders related to the excessive activity of the pituitary gland, which regulates vital hormones affecting growth, reproduction, and fluid balance. These codes are used to classify different types of pituitary hyperfunction.
This section includes specific codes such as E22.0 for Acromegaly and pituitary gigantism, conditions resulting from growth hormone overproduction and known also by terms like "gigantism" or "acromegalic facies." The code E22.1 identifies Hyperprolactinemia, a state of elevated prolactin hormone, sometimes linked to hypothyroidism or pituitary stalk compression. E22.2 corresponds to the Syndrome of inappropriate secretion of antidiuretic hormone (SIADH), which involves abnormal vasopressin release impacting water balance. Other hyperpituitarism forms, such as premature puberty or excess gonadotrophins, fall under E22.8. When the specific cause is unknown, E22.9 is used to denote unspecified hyperfunction of the pituitary gland, also referred to as hyperpituitarism. Understanding these ICD-10 codes for pituitary gland hyperfunction helps in accurate diagnosis, treatment planning, and clinical documentation.
Endocrine, nutritional and metabolic diseases (E00–E89)
Disorders of other endocrine glands (E20-E35)
E22 Hyperfunction of pituitary gland
- E22.0 Acromegaly and pituitary gigantism
- E22.1 Hyperprolactinemia
- E22.2 Syndrome of inappropriate secretion of antidiuretic hormone
- E22.8 Other hyperfunction of pituitary gland
- E22.9 Hyperfunction of pituitary gland, unspecified
Hyperfunction of pituitary gland (E22)
Instructional Notations
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- Cushing's syndrome E24
- Nelson's syndrome E24.1
- overproduction of ACTH not associated with Cushing's disease E27.0
- overproduction of pituitary ACTH E24.0
- overproduction of thyroid-stimulating hormone E05.8
Clinical Terms
The following clinical terms provide additional context, helping users better understand the clinical background and common associations for each diagnosis listed in this section. Including related terms alongside ICD-10-CM codes supports coders, billers, and healthcare professionals in improving accuracy, enhancing documentation, and facilitating research or patient education.
Acromegaly
A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
Gigantism
The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
Growth Hormone-Secreting Pituitary Adenoma
A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.
Hyperpituitarism
Disease of the glandular, anterior portion of the pituitary (PITUITARY GLAND, ANTERIOR) resulting in hypersecretion of ADENOHYPOPHYSEAL HORMONES such as GROWTH HORMONE; PROLACTIN; THYROTROPIN; LUTEINIZING HORMONE; FOLLICLE STIMULATING HORMONE ; and ADRENOCORTICOTROPIC HORMONE. Hyperpituitarism usually is caused by a functional ADENOMA.
Hyperprolactinemia
Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)
Sotos Syndrome
Congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.
