Hyperfunction of pituitary gland (E22) ICD-10-CM
The E22 code range covers hyperfunction of pituitary gland with 6 ICD-10-CM diagnosis codes. 5 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Codes in the E22 Range 6 codes · 5 billable
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the E22 range.
Acromegaly
A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
Gigantism
The condition of accelerated and excessive GROWTH in children or adolescents who are exposed to excess HUMAN GROWTH HORMONE before the closure of EPIPHYSES. It is usually caused by somatotroph hyperplasia or a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. These patients are of abnormally tall stature, more than 3 standard deviations above normal mean height for age.
Growth Hormone-Secreting Pituitary Adenoma
A pituitary tumor that secretes GROWTH HORMONE. In humans, excess HUMAN GROWTH HORMONE leads to ACROMEGALY.
Hyperpituitarism
Disease of the glandular, anterior portion of the pituitary (PITUITARY GLAND, ANTERIOR) resulting in hypersecretion of ADENOHYPOPHYSEAL HORMONES such as GROWTH HORMONE; PROLACTIN; THYROTROPIN; LUTEINIZING HORMONE; FOLLICLE STIMULATING HORMONE ; and ADRENOCORTICOTROPIC HORMONE. Hyperpituitarism usually is caused by a functional ADENOMA.
Hyperprolactinemia
Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)
Sotos Syndrome
Congenital or postnatal overgrowth syndrome most often in height and occipitofrontal circumference with variable delayed motor and cognitive development. Other associated features include advanced bone age, seizures, NEONATAL JAUNDICE; HYPOTONIA; and SCOLIOSIS. It is also associated with increased risk of developing neoplasms in adulthood. Mutations in the NSD1 protein and its HAPLOINSUFFICIENCY are associated with the syndrome.
About the E22 Code Range
The E22 ICD-10 code section covers disorders related to the excessive activity of the pituitary gland, which regulates vital hormones affecting growth, reproduction, and fluid balance. These codes are used to classify different types of pituitary hyperfunction.
This section includes specific codes such as E22.0 for Acromegaly and pituitary gigantism, conditions resulting from growth hormone overproduction and known also by terms like "gigantism" or "acromegalic facies." The code E22.1 identifies Hyperprolactinemia, a state of elevated prolactin hormone, sometimes linked to hypothyroidism or pituitary stalk compression. E22.2 corresponds to the Syndrome of inappropriate secretion of antidiuretic hormone (SIADH), which involves abnormal vasopressin release impacting water balance. Other hyperpituitarism forms, such as premature puberty or excess gonadotrophins, fall under E22.8. When the specific cause is unknown, E22.9 is used to denote unspecified hyperfunction of the pituitary gland, also referred to as hyperpituitarism. Understanding these ICD-10 codes for pituitary gland hyperfunction helps in accurate diagnosis, treatment planning, and clinical documentation.
Questions About This Page
How many billable codes are in the E22 range?
Of the 6 codes in this range, 5 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the E22 range classify?
The range classifies hyperfunction of pituitary gland. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
