Polyglandular dysfunction (E31)

• ICD-10 Index

  • Endocrine, nutritional and metabolic diseases (E00–E90)

    • Disorders of other endocrine glands (E20-E35)

      • Polyglandular dysfunction (E31)

        • E31 - Polyglandular dysfunction NON-BILLABLE CODE
        • E31.0 - Autoimmune polyglandular failure BILLABLE CODE
        • E31.1 - Polyglandular hyperfunction BILLABLE CODE
        • E31.2 - Multiple endocrine neoplasia [MEN] syndromes NON-BILLABLE CODE
        • E31.20 - Multiple endocrine neoplasia [MEN] syndrome, unspecified BILLABLE CODE
        • E31.21 - Multiple endocrine neoplasia [MEN] type I BILLABLE CODE
        • E31.22 - Multiple endocrine neoplasia [MEN] type IIA BILLABLE CODE
        • E31.23 - Multiple endocrine neoplasia [MEN] type IIB BILLABLE CODE
        • E31.8 - Other polyglandular dysfunction BILLABLE CODE
        • E31.9 - Polyglandular dysfunction, unspecified BILLABLE CODE

Clinical Information for Polyglandular dysfunction (E31)

Multiple Endocrine Neoplasia Type 2a - A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.

Multiple Endocrine Neoplasia Type 1 - A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).

Instructional Notations

Type 1 Excludes Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

• ataxia telangiectasia [Louis-Bar] G11.3
• dystrophia myotonica [Steinert] G71.11
• pseudohypoparathyroidism E20.1