Polyglandular dysfunction (E31) ICD-10-CM
The E31 code range covers polyglandular dysfunction with 10 ICD-10-CM diagnosis codes. 8 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Codes in the E31 Range 10 codes · 8 billable
- E31 Polyglandular dysfunctionNon-billable
- E31.0 Autoimmune polyglandular failure
- E31.1 Polyglandular hyperfunction
- E31.2 Multiple endocrine neoplasia [MEN] syndromesNon-billable
- E31.20 Multiple endocrine neoplasia [MEN] syndrome, unspecified
- E31.21 Multiple endocrine neoplasia [MEN] type I
- E31.22 Multiple endocrine neoplasia [MEN] type IIA
- E31.23 Multiple endocrine neoplasia [MEN] type IIB
- E31.8 Other polyglandular dysfunction
- E31.9 Polyglandular dysfunction, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the E31 range.
Multiple Endocrine Neoplasia Type 1
Multiple endocrine neoplasia caused by inactivation of the tumor suppressor gene MEN-1. Patients may develop hyperparathyroidism and parathyroid gland adenomas, pituitary gland adenomas, and neuroendocrine tumors.
Multiple Endocrine Neoplasia Type 2a
A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
Multiple Endocrine Neoplasia Type 2B
Multiple endocrine neoplasia caused by mutation of the RET gene. Patients develop medullary thyroid carcinomas and numerous neural defects including neuromas.
About the E31 Code Range
Polyglandular dysfunction involves problems with multiple endocrine glands. E31 sits within disorders of other endocrine glands.
Its subdivisions distinguish autoimmune gland failure, gland overactivity, and multiple endocrine neoplasia (MEN) syndromes. E31.2 separates MEN by type I, IIA, IIB, or unspecified type. Other and unspecified polyglandular dysfunction have separate codes.
Questions About This Page
How many billable codes are in the E31 range?
Of the 10 codes in this range, 8 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the E31 range classify?
The range classifies polyglandular dysfunction. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
