Adrenogenital disorders (E25) ICD-10-CM
The E25 code range covers adrenogenital disorders with 4 ICD-10-CM diagnosis codes. 3 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
- adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
- Female adrenal pseudohermaphroditism
- Female heterosexual precocious pseudopuberty
- Male isosexual precocious pseudopuberty
- Male macrogenitosomia praecox
- Male sexual precocity with adrenal hyperplasia
- Male virilization (female)
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Codes in the E25 Range 4 codes · 3 billable
About the E25 Code Range
The ICD-10 code section E25 covers adrenogenital disorders, which are conditions affecting the adrenal glands that impact the development and function of sexual characteristics. These codes are used to classify various congenital and acquired disorders involving enzyme deficiencies and hormonal imbalances that lead to atypical genital development and hormone-related syndromes.
Specifically, E25.0 addresses congenital adrenogenital disorders due to enzyme deficiencies, such as congenital adrenal hyperplasia (CAH). This includes conditions known by terms like male or female pseudohermaphroditism, 21-hydroxylase deficiency, and adrenal virilism. These represent enzyme defects that disrupt steroid hormone production, causing issues like salt-wasting crises or abnormal sexual development. E25.8 captures other adrenogenital disorders, including drug- or idiopathic-induced syndromes and precocious puberty variants, involving terms like feminization, masculinization, and Achard-Thiers syndrome. Finally, E25.9 is used when the specific adrenogenital disorder is unspecified and may include general descriptions such as virilization, adrenal hyperfunction, or various Tanner genital development stages. These ICD-10 codes are essential for accurately documenting diverse adrenal gland-related endocrine disorders and their clinical presentations.
Questions About This Page
How many billable codes are in the E25 range?
Of the 4 codes in this range, 3 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the E25 range classify?
The range classifies adrenogenital disorders. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
