Other disorders of adrenal gland (E27) ICD-10-CM
The E27 code range covers other disorders of adrenal gland with 11 ICD-10-CM diagnosis codes. 9 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Codes in the E27 Range 11 codes · 9 billable
- E27 Other disorders of adrenal glandNon-billable
- E27.0 Other adrenocortical overactivity
- E27.1 Primary adrenocortical insufficiency
- E27.2 Addisonian crisis
- E27.3 Drug-induced adrenocortical insufficiency
- E27.4 Other and unspecified adrenocortical insufficiencyNon-billable
- E27.40 Unspecified adrenocortical insufficiency
- E27.49 Other adrenocortical insufficiency
- E27.5 Adrenomedullary hyperfunction
- E27.8 Other specified disorders of adrenal gland
- E27.9 Disorder of adrenal gland, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the E27 range.
Addison Disease
An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
Adrenal Crisis
A life threatening condition due to inadequate levels of glucocorticoids in an individual with adrenal insufficiency.
Adrenal Insufficiency
Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.
Adrenocortical Hyperfunction
Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.
Hypoaldosteronism
A congenital or acquired condition of insufficient production of ALDOSTERONE by the ADRENAL CORTEX leading to diminished aldosterone-mediated synthesis of Na(+)-K(+)-EXCHANGING ATPASE in renal tubular cells. Clinical symptoms include HYPERKALEMIA, sodium-wasting, HYPOTENSION, and sometimes metabolic ACIDOSIS.
About the E27 Code Range
These adrenal gland disorders include overactivity, insufficient activity, and other specified or unspecified problems with the gland.
The subdivisions distinguish problems of the adrenal cortex from overactivity of the adrenal medulla. E27.0 identifies other overactivity of the cortex, while E27.5 identifies overactivity of the medulla.
Cortical insufficiency is divided into primary E27.1, drug-induced E27.3, and other or unspecified E27.4 forms. The last group separates unspecified E27.40 from other E27.49 insufficiency. E27.2 identifies an Addisonian crisis. E27.8 and E27.9 distinguish other specified gland disorders from unspecified ones.
Questions About This Page
How many billable codes are in the E27 range?
Of the 11 codes in this range, 9 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the E27 range classify?
The range classifies other disorders of adrenal gland. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
