Other disorders of adrenal gland (E27) ICD-10-CM
The E27 code range covers other disorders of adrenal gland with 11 ICD-10-CM diagnosis codes. 9 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Codes in the E27 Range 11 codes · 9 billable
- E27 Other disorders of adrenal glandNon-billable
- E27.0 Other adrenocortical overactivity
- E27.1 Primary adrenocortical insufficiency
- E27.2 Addisonian crisis
- E27.3 Drug-induced adrenocortical insufficiency
- E27.4 Other and unspecified adrenocortical insufficiencyNon-billable
- E27.40 Unspecified adrenocortical insufficiency
- E27.49 Other adrenocortical insufficiency
- E27.5 Adrenomedullary hyperfunction
- E27.8 Other specified disorders of adrenal gland
- E27.9 Disorder of adrenal gland, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the E27 range.
Adrenarche
A stage of development at which the ADRENAL GLANDS undergo maturation leading to the capability of producing increasing amounts of adrenal androgens, DEHYDROEPIANDROSTERONE and ANDROSTENEDIONE. Adrenarche usually begins at about 7 or 8 years of age before the signs of PUBERTY and continues throughout puberty.
Adrenocortical Hyperfunction
Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.
Carney Complex
Autosomal dominant syndrome characterized by cardiac and cutaneous MYXOMAS; LENTIGINOSIS (spotty pigmentation of the skin), and endocrinopathy and its associated endocrine tumors. The cardiac myxomas may lead to SUDDEN CARDIAC DEATH and other complications in Carney complex patients. The gene coding for the PRKAR1A protein is one of the causative genetic loci (type 1). A second locus is at chromosome 2p16 (type 2).
About the E27 Code Range
The ICD-10 code E27 category covers various other disorders of the adrenal gland, including both overactivity and insufficiency conditions not classified elsewhere. These codes are essential for identifying distinct adrenal gland issues such as adrenal hyperfunction, insufficiency, and related crises.
The section includes codes like E27.0 for other adrenocortical overactivity, which encompasses conditions such as premature adrenarche, adrenal virilism, and ACTH hypersecretion without Cushing’s syndrome. E27.1 and E27.4 cover primary and unspecified adrenocortical insufficiency, respectively, including Addison’s disease and familial steroid-resistant nephrotic syndrome with adrenal insufficiency. The E27.2 code identifies the acute and severe form known as Addisonian crisis. Drug-related causes fall under E27.3 for drug-induced insufficiency. Other noteworthy codes are E27.5 for adrenomedullary hyperfunction involving catecholamine excess and E27.8 for other specified disorders like adrenal hyperplasia or inflammation. For conditions that cannot be specifically classified, E27.9 is used. These are critical ICD-10 codes for medical coders diagnosing adrenal gland disorders.
Questions About This Page
How many billable codes are in the E27 range?
Of the 11 codes in this range, 9 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the E27 range classify?
The range classifies other disorders of adrenal gland. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
