Hypofunction and other disorders of the pituitary gland (E23) ICD-10-CM
The E23 code range covers hypofunction and other disorders of the pituitary gland with 7 ICD-10-CM diagnosis codes. 6 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Includes
This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
- the listed conditions whether the disorder is in the pituitary or the hypothalamus
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Codes in the E23 Range 7 codes · 6 billable
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the E23 range.
Autoimmune Hypophysitis
Immune-mediated inflammation of the PITUITARY GLAND often associated with other autoimmune diseases (e.g., HASHIMOTO DISEASE; GRAVES DISEASE; and ADDISON DISEASE).
Cerebrospinal Fluid Rhinorrhea
Discharge of cerebrospinal fluid through the nose. Common etiologies include trauma, neoplasms, and prior surgery, although the condition may occur spontaneously. (Otolaryngol Head Neck Surg 1997 Apr;116(4):442-9)
Diabetes Insipidus
A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.
Diabetes Insipidus, Nephrogenic
A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to renal tubular insensitivity to VASOPRESSIN and failure to reduce urine volume. It may be the result of mutations of genes encoding VASOPRESSIN RECEPTORS or AQUAPORIN-2; KIDNEY DISEASES; adverse drug effects; or complications from PREGNANCY.
Diabetes Insipidus, Neurogenic
A genetic or acquired polyuric disorder caused by a deficiency of VASOPRESSINS secreted by the NEUROHYPOPHYSIS. Clinical signs include the excretion of large volumes of dilute URINE; HYPERNATREMIA; THIRST; and polydipsia. Etiologies include HEAD TRAUMA; surgeries and diseases involving the HYPOTHALAMUS and the PITUITARY GLAND. This disorder may also be caused by mutations of genes such as ARVP encoding vasopressin and its corresponding neurophysin (NEUROPHYSINS).
Empty Sella Syndrome
A condition when the SELLA TURCICA is not filled with pituitary tissue. The pituitary gland is either compressed, atrophied, or removed. There are two types: (1) primary empty sella is due a defect in the sella diaphragm leading to arachnoid herniation into the sellar space; (2) secondary empty sella is associated with the removal or treatment of PITUITARY NEOPLASMS.
Hypernatremia
Excessive amount of sodium in the blood. (Dorland, 27th ed)
Hypohidrosis
Abnormally diminished or absent perspiration. Both generalized and segmented (reduced or absent sweating in circumscribed locations) forms of the disease are usually associated with other underlying conditions.
Hypophysitis
Inflammation of the PITUITARY GLAND.
Hypopituitarism
Diminution or cessation of secretion of one or more hormones from the anterior pituitary gland (including LH; FOLLICLE STIMULATING HORMONE; SOMATOTROPIN; and CORTICOTROPIN). This may result from surgical or radiation ablation, non-secretory PITUITARY NEOPLASMS, metastatic tumors, infarction, PITUITARY APOPLEXY, infiltrative or granulomatous processes, and other conditions.
Moyamoya Disease
A noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults.
Pituitary Apoplexy
The sudden loss of blood supply to the PITUITARY GLAND, leading to tissue NECROSIS and loss of function (PANHYPOPITUITARISM). The most common cause is hemorrhage or INFARCTION of a PITUITARY ADENOMA. It can also result from acute hemorrhage into SELLA TURCICA due to HEAD TRAUMA; INTRACRANIAL HYPERTENSION; or other acute effects of central nervous system hemorrhage. Clinical signs include severe HEADACHE; HYPOTENSION; bilateral visual disturbances; UNCONSCIOUSNESS; and COMA.
Pituitary Gland
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
Wolfram Syndrome
A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.
About the E23 Code Range
The ICD-10 code section E23 classifies hypofunction and other disorders of the pituitary gland, which regulate crucial hormonal functions. These codes are used to identify specific pituitary gland conditions ranging from hormone deficiencies to structural disorders.
The code E23.0 denotes hypopituitarism, covering numerous related terms such as isolated gonadotropin deficiency and Sheehan's syndrome, helping coders address complex pituitary hormone deficiencies. E23.1 specifies drug-induced hypopituitarism, including cases caused by medications or iron overload. E23.2 covers diabetes insipidus, linked to vasopressin deficiency and syndromes like Wolfram syndrome. The code E23.3 is for hypothalamic dysfunction not elsewhere classified, addressing disorders affecting hormonal regulation and symptoms like amenorrhea and defective osmoregulation. E23.6 includes other pituitary disorders such as pituitary cysts, hypophysitis, and empty sella syndrome. Lastly, E23.7 identifies unspecified pituitary gland disorders, useful when the exact condition is unclear but originates from pituitary abnormalities.
These ICD-10 codes are essential for accurately coding a variety of pituitary diseases, facilitating proper diagnosis and treatment documentation for conditions referred to by their common names like hypopituitarism, diabetes insipidus, or hypothalamic syndrome. Using the ICD-10 code for pituitary gland disorders ensures clear communication among healthcare providers and supports targeted care strategies.
Questions About This Page
How many billable codes are in the E23 range?
Of the 7 codes in this range, 6 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the E23 range classify?
The range classifies hypofunction and other disorders of the pituitary gland. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
