2027 ICD-10-CM Diagnosis Code E88.9Metabolic disorder, unspecified
ICD-10-CM Codes›E00–E89›E70-E88›E88
- Billable — Valid for Submission
- Chronic Condition
E88.9 is a billable ICD-10-CM diagnosis code for metabolic disorder, unspecified. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 642. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Abnormal metabolic requirement
- Abnormal metabolic state due to diabetes mellitus
- Acute confusional state, of metabolic origin
- Acute metabolic disorder
- Acute symptomatic epileptic seizure due to metabolic disorder
- Amino acid deficiency
- Anemia due to metabolic disorder
- Aplastic anemia associated with metabolic alteration
- Arthropathy associated with an endocrine AND/OR metabolic disorder
- Arthropathy due to metabolic disorder
- Autonomic disorder due to metabolic disorder
- Autonomic neuropathy due to metabolic disease
- Benign intracranial hypertension
- Benign intracranial hypertension due to metabolic disease
- Bilateral deposit in corneas
- Cardiac glycogenosis
- Cardiomyopathy due to storage disease
- Carnitine deficiency
- Carnitine deficiency due to inborn error of metabolism
- Chorea due to inborn error of metabolism
- Chorea due to metabolic disorder
- Chronic metabolic disorder
- Chronic tubulointerstitial nephritis due to metabolic disease
- Clinical manifestation of enzyme deficiency
- Corneal deposits due to metabolic disorder
- Defective biosynthesis
- Defective metabolism
- Dementia due to metabolic abnormality
- Deposit in cornea of bilateral eyes due to metabolic disorder
- Deposit in cornea of left eye due to metabolic disorder
- Deposit in cornea of right eye due to metabolic disorder
- Dilated cardiomyopathy due to metabolic disorder
- Disorder of neurometabolic regulation
- Enzymopathy
- Familial cardiomyopathy
- Familial restrictive cardiomyopathy
- Generalized metabolic disorder
- Glaucoma in endocrine, nutritional and metabolic diseases
- Hereditary metabolic disease
- Hypopituitarism due to metabolic disease
- Inborn error of metabolism
- Infiltrative cardiomyopathy
- Inherited metabolic disorder of nervous system
- Interstitial lung disease due to metabolic disease
- Intrinsic staining of tooth - metabolic disease
- Localized metabolic disorder
- Metabolic and genetic disorder affecting the liver
- Metabolic and nutritional disorders affecting skin
- Metabolic bone disease
- Metabolic complication of procedures
- Metabolic disease
- Metabolic disturbance in labor AND/OR delivery
- Metabolic ileus
- Metabolic myopathy
- Metabolic neuropathy
- Metabolic presbycusis
- Metabolic renal disease
- Myelopathy due to metabolic disorder
- Navajo neurohepatopathy
- Neonatal metabolic disorder
- Neuropathy of upper limb due to metabolic disorder
- Nutritional myopathy
- Pericarditis due to metabolic disease
- Peripheral neuropathy due to metabolic disorder
- Presbycusis
- Radiculopathy due to metabolic disorder
- Restrictive cardiomyopathy secondary to familial storage disease
- Secondary carnitine deficiency
- Sinus bradycardia
- Sinus bradycardia due to metabolic disease
- Splenomegaly due to storage disease
- Storage disease
- Thrombocytopenic purpura associated with metabolic disorder
- Tremor due to metabolic disorder
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E88.9: its own notes plus those printed at E88, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- histiocytosis X (chronic) (C96.6)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- Ehlers-Danlos syndromes (Q79.6-)
Use Additional Code
Add a second code, after this one, to fully describe the condition.
- codes for associated conditions
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) M19.90
metabolic disorder NEC See Also: subcategory M14.8-; E88.9
Arthropathy See Also: Arthritis; M12.9
Disease, diseased See Also: Syndrome;
metabolic, metabolism E88.9
Disorder (of) See Also: Disease;
metabolism NOS E88.9
congenital E88.9
Disturbance (s) See Also: Disease;
metabolism E88.9
general E88.9
peripheral (nerve) See Also: Polyneuropathy; G62.9
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Metabolic Disorder
a congenital (due to inherited enzyme abnormality) or acquired (due to failure of a metabolic important organ) disorder resulting from an abnormal metabolic process.
Patient EducationClinical
Metabolic Disorders
Metabolism is the process your body uses to get or make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system break the food parts down into sugars and acids, your body's fuel.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E88.9 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E88.9Overview
What is the ICD-10 code for metabolic disorder, unspecified?
The ICD-10-CM code for metabolic disorder, unspecified is E88.9 (sometimes written as E889). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E88.9 (Other and unspecified metabolic disorders) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report metabolic disorder, unspecified on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E88.9 group to?
When metabolic disorder, unspecified is the principal diagnosis on an inpatient stay, it groups to MS-DRG 642 (inborn and Other Disorders of Metabolism), which carries a relative weight of 1.3226. Higher weights mean higher Medicare reimbursement.
Can E88.9 be reported with C96.6?
Not as a rule. The Excludes1 note at E88, which applies to E88.9, lists "histiocytosis X (chronic) (C96.6)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does E88.9 need an additional code?
When the condition applies, yes. The Use Additional Code note at E88, which applies to E88.9, reads: codes for associated conditions. The additional code is reported after E88.9.
