2027 ICD-10-CM Diagnosis Code E29.1Testicular hypofunction

ICD-10-CM Codes›E00–E89›E20-E35›E29

ICD-10-CM E29.1
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E29.1 is a billable ICD-10-CM diagnosis code for testicular hypofunction. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E29.1
Billable Status
Yes — Valid for Submission
Code Describes
Testicular hypofunction
Short Description
Testicular hypofunction
Same as the full description in the CMS dataset.
Parent Code
Testicular dysfunction

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE29Testicular dysfunction
This CodeE29.1Testicular hypofunction

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired male infertility
  • Acquired testicular failure
  • Atypical ichthyosis vulgaris with hypogonadism
  • Bird-headed dwarfism with progressive ataxia, insulin-resistant diabetes, goiter, and primary gonadal insufficiency
  • Boucher Neuhäuser syndrome
  • Central obesity
  • Colobomatous microphthalmia
  • Colobomatous microphthalmia, obesity, hypogenitalism, intellectual disability syndrome
  • Congenital absence of abdominal muscle
  • Congenital cataract with deafness and hypogonadism syndrome
  • Congenital muscular dystrophy with infantile cataract and hypogonadism syndrome
  • Cutaneous syndrome with ichthyosis
  • Deafness and hypogonadism syndrome
  • Deficiency of testosterone biosynthesis
  • Dilated cardiomyopathy with hypergonadotropic hypogonadism syndrome
  • Disorder of androgen receptor
  • Eunuchism
  • Hereditary choroidal dystrophy
  • Hydrocephalus with obesity and hypogonadism syndrome
  • Hypogonadal facial wrinkling
  • Hypogonadal facies
  • Hypogonadism
  • Hypogonadism with mitral valve prolapse and intellectual disability syndrome
  • Hypogonadism with prune belly syndrome
  • Induced male hypogonadism syndrome
  • Infantile and/or juvenile cataract
  • Infantile cataract
  • Infantilism
  • Intellectual disability, craniofacial dysmorphism, hypogonadism, diabetes mellitus syndrome
  • Leydig cell failure in adult
  • MacDermot Winter syndrome
  • Male hypogonadism
  • MEHMO syndrome
  • Nonsenile cataract
  • Normogonadotropic hypogonadism
  • Primary hypogonadism
  • Primary testicular failure
  • Progressive cerebellar ataxia
  • Progressive cerebellar ataxia with hypogonadism
  • Prune belly syndrome
  • Retinitis pigmentosa, intellectual disability, deafness, hypogenitalism syndrome
  • Seminiferous tubule failure in adult
  • Structural abnormality of abdominal wall muscle
  • Syndromic X-linked intellectual disability type 7
  • Testicular hypofunction
  • Testicular hypofunction caused by ionizing radiation
  • Testicular hypofunction due to defect in adrenocortical hormone synthesis
  • Undervirilization
  • Undervirilization of male due to steroidogenic acute regulatory protein deficiency
  • Woodhouse Sakati syndrome
  • X-linked intellectual disability, hypogonadism, ichthyosis, obesity, short stature syndrome

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E29.1: its own notes plus those printed at E29, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Defective biosynthesis of testicular androgen NOS
  • 5-Alpha-reductase deficiency (with male pseudohermaphroditism)
  • Testicular hypogonadism NOS

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

On E29.1 itself
  • postprocedural testicular hypofunction (E89.5)
From E29 Testicular dysfunction applies to 4 codes
From Block E20-E35 Disorders of other endocrine glands applies to 99 codes
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E29.1, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming E29.1: they are not reported together with it, unless the two conditions are unrelated.

  • Block E70-E88 Metabolic disorders
    5-alpha-reductase deficiency (E29.1)

Code First 1

These codes say to code first a condition named in the note, and E29.1 is one of the conditions named.

  • G63 Polyneuropathy in diseases classified elsewhere
    endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34) names E20-E34, which includes this code

Notes 1

These notes mention E29.1.

  • Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases
    All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code

Index to Diseases and InjuriesGuidance

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Eunuchoidism

    eunuch-like state in which the male individual has non-functional testes.

Patient EducationClinical

Testicular Disorders

Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. It's easy to injure your testicles because they are not protected by bones or muscles. Men and boys should wear athletic supporters when they play sports.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E29.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
257.2 Testicular hypofunc NEC
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E29.1Overview

What is the ICD-10 code for testicular hypofunction?

The ICD-10-CM code for testicular hypofunction is E29.1 (sometimes written as E291). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E29.1 (Testicular dysfunction) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report testicular hypofunction on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E29.1 group to?

When testicular hypofunction is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.

Can E29.1 be reported with E89.5?

Not as a rule. The Excludes1 note on E29.1 lists "postprocedural testicular hypofunction (E89.5)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does E29.1 need an additional code?

When the condition applies, yes. The Use Additional Code note reads: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5). The additional code is reported after E29.1.