2026 ICD-10-CM Diagnosis Code E29.1Testicular hypofunction
ICD-10-CM Codes›E00–E89›E20-E35›E29
- Billable — Valid for Submission
- Chronic Condition
E29.1 is a billable ICD-10-CM diagnosis code for testicular hypofunction. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.
Code Identity
Code Classification
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acquired male infertility
- Acquired testicular failure
- Atypical ichthyosis vulgaris with hypogonadism
- Bird-headed dwarfism with progressive ataxia, insulin-resistant diabetes, goiter, and primary gonadal insufficiency
- Boucher Neuhäuser syndrome
- Central obesity
- Colobomatous microphthalmia
- Colobomatous microphthalmia, obesity, hypogenitalism, intellectual disability syndrome
- Congenital absence of abdominal muscle
- Congenital cataract with deafness and hypogonadism syndrome
- Congenital muscular dystrophy with infantile cataract and hypogonadism syndrome
- Cutaneous syndrome with ichthyosis
- Deafness and hypogonadism syndrome
- Deficiency of testosterone biosynthesis
- Diabetes mellitus associated with genetic syndrome
- Disorder of androgen receptor
- Eunuchism
- Hereditary choroidal dystrophy
- Hydrocephalus with obesity and hypogonadism syndrome
- Hypogonadal facial wrinkling
- Hypogonadal facies
- Hypogonadism
- Hypogonadism with mitral valve prolapse and intellectual disability syndrome
- Hypogonadism with prune belly syndrome
- Induced male hypogonadism syndrome
- Infantile and/or juvenile cataract
- Infantile cataract
- Infantilism
- Intellectual disability, craniofacial dysmorphism, hypogonadism, diabetes mellitus syndrome
- Leydig cell failure in adult
- MacDermot Winter syndrome
- Male hypogonadism
- MEHMO syndrome
- Nonsenile cataract
- Primary hypogonadism
- Primary testicular failure
- Progressive cerebellar ataxia
- Progressive cerebellar ataxia with hypogonadism
- Prune belly syndrome
- Retinitis pigmentosa, intellectual disability, deafness, hypogenitalism syndrome
- Seminiferous tubule failure in adult
- Syndromic X-linked intellectual disability type 7
- Testicular hypofunction
- Testicular hypofunction caused by ionizing radiation
- Testicular hypofunction due to defect in adrenocortical hormone synthesis
- Undervirilization
- Undervirilization of male due to steroidogenic acute regulatory protein deficiency
- Woodhouse Sakati syndrome
- X-linked intellectual disability, hypogonadism, ichthyosis, obesity, short stature syndrome
Tabular List NotesGuidance
Coding notes and annotation back-references applicable to this code.
Inclusion Terms
- Defective biosynthesis of testicular androgen NOS
- 5-delta-Reductase deficiency (with male pseudohermaphroditism)
- Testicular hypogonadism NOS
Use Additional Code
Type 1 Excludes
- postprocedural testicular hypofunction E89.5
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
- Abnormal, abnormality, abnormalities - See Also: Anomaly;
- biosynthesis, testicular androgen - E29.1
- biosynthesis, androgen (testicular) - E29.1
- 5-alpha reductase (with male pseudohermaphroditism) - E29.1
- hormone
- testicular - E29.1
- Eunuchoidism - E29.1
- Leydig's cell, adult - E29.1
- seminiferous tubule, adult - E29.1
- testicular endocrine function - E29.1
- testicular - E29.1
- male - E29.1
- testicular (primary) - E29.1
- Panhypogonadism - E29.1
- Pseudohermaphroditism - Q56.3
- male - See Also: Disorder, adrenogenital; - Q56.1
- with
- 5-alpha-reductase deficiency - E29.1
- Syndrome - See Also: Disease;
- prepubertal castrate - E29.1
- Undeveloped, undevelopment - See Also: Hypoplasia;
- testis - E29.1
External Cause of Injuries IndexGuidance
References for this code in the External Cause of Injuries Index.
- Abnormal, abnormality, abnormalities
- biosynthesis, testicular androgen
- Defect, defective
- biosynthesis, androgen (testicular)
- Deficiency, deficient
- 5-alpha reductase (with male pseudohermaphroditism)
- Deficiency, deficient
- hormone
- testicular
- Eunuchoidism
- Failure, failed
- Leydig's cell, adult
- Failure, failed
- seminiferous tubule, adult
- Failure, failed
- testicular endocrine function
- Hypofunction
- testicular
- Hypogonadism
- male
- Hypogonadism
- testicular (primary)
- Infantile
- testis
- Insufficiency, insufficient
- gonadal
- testis
- Insufficiency, insufficient
- testis
- Panhypogonadism
- Pseudohermaphroditism
- male
- with
- 5-alpha-reductase deficiency
- Syndrome
- functional
- prepubertal castrate
- Undeveloped, undevelopment
- testis
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Eunuchism
the state of being a eunuch, a male without testes or whose testes failed to develop. it is characterized by the lack of mature male germ cells and testicular hormones.Hypogonadism
condition resulting from deficient gonadal functions, such as gametogenesis and the production of gonadal steroid hormones. it is characterized by delay in growth, germ cell maturation, and development of secondary sex characteristics. hypogonadism can be due to a deficiency of gonadotropins (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).Kallmann Syndrome
a genetically heterogeneous disorder caused by hypothalamic gnrh deficiency and olfactory nerve defects. it is characterized by congenital hypogonadotropic hypogonadism and anosmia, possibly with additional midline defects. it can be transmitted as an x-linked (genetic diseases, x-linked), an autosomal dominant, or an autosomal recessive trait.Spinocerebellar Degenerations
a heterogenous group of degenerative syndromes marked by progressive cerebellar dysfunction either in isolation or combined with other neurologic manifestations. sporadic and inherited subtypes occur. inheritance patterns include autosomal dominant, autosomal recessive, and x-linked.Prune Belly Syndrome
a syndrome characterized by abdominal wall musculature deficiency, cryptorchism, and urinary tract abnormalities. the syndrome derives its name from its characteristic distended abdomen with wrinkled skin.Acquired Testicular Failure
testicular failure, the cause of which is not present at birth.
Patient EducationClinical
Testicular Disorders
Testicles, or testes, make male hormones and sperm. They are two egg-shaped organs inside the scrotum, the loose sac of skin behind the penis. It's easy to injure your testicles because they are not protected by bones or muscles. Men and boys should wear athletic supporters when they play sports.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E29.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E29.1Overview
Is E29.1 (Testicular dysfunction) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report testicular hypofunction on HIPAA-covered claims from October 1, 2025 through September 30, 2026.
What MS-DRG does E29.1 group to?
When testicular hypofunction is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.
What is the ICD-9 equivalent of E29.1?
Under the General Equivalence Mappings, testicular hypofunction converts to ICD-9-CM 257.2 (testicular hypofunc NEC). The mapping is a direct match.
Footnotes
[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:
- The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
- The condition places limitations on self-care, independent living, and social interactions.
