ICD-10-CM Code E28.39

Other primary ovarian failure

Version 2020 Billable Code Diagnoses For Females Only

Valid for Submission

E28.39 is a billable code used to specify a medical diagnosis of other primary ovarian failure. The code is valid for the year 2020 for the submission of HIPAA-covered transactions. The ICD-10-CM code E28.39 might also be used to specify conditions or terms like atypical ichthyosis vulgaris with hypogonadism, autoimmune primary ovarian failure, bird-headed dwarfism with progressive ataxia, insulin-resistant diabetes, goiter, and primary gonadal insufficiency, boucher neuhäuser syndrome, central obesity, central obesity, etc

The code E28.39 is applicable to female patients only. It is clinically and virtually impossible to use this code on a non-female patient.

Short Description:Other primary ovarian failure
Long Description:Other primary ovarian failure

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E28.39:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Decreased estrogen
  • Resistant ovary syndrome

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code E28.39 are found in the index:

Code Edits

The Medicare Code Editor (MCE) detects and reports errors in the coding of claims data. The following ICD-10 Code Edits are applicable to this code:

  • Diagnoses for females only - Medicare Code Editor detects inconsistencies between a patient’s sex and any diagnosis on the patient’s record, this code applies to FEMALES only .


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Atypical ichthyosis vulgaris with hypogonadism
  • Autoimmune primary ovarian failure
  • Bird-headed dwarfism with progressive ataxia, insulin-resistant diabetes, goiter, and primary gonadal insufficiency
  • Boucher Neuhäuser syndrome
  • Central obesity
  • Central obesity
  • Colobomatous microphthalmia
  • Colobomatous microphthalmia, obesity, hypogenitalism, intellectual disability syndrome
  • Congenital absence of abdominal muscle
  • Congenital cataract with deafness and hypogonadism syndrome
  • Congenital muscular dystrophy with infantile cataract and hypogonadism syndrome
  • Corpus luteum deficiency syndrome
  • Cutaneous syndrome with ichthyosis
  • Deafness and hypogonadism syndrome
  • Decreased estrogen level
  • Female hypogonadism syndrome
  • Female hypogonadotropic hypogonadism
  • Female infertility due to diminished ovarian reserve
  • Hydrocephalus with obesity and hypogonadism syndrome
  • Hypogonadal facial wrinkling
  • Hypogonadal facies
  • Hypogonadism
  • Hypogonadism with mitral valve prolapse and intellectual disability syndrome
  • Hypogonadism with prune belly syndrome
  • Hypogonadism, diabetes mellitus, alopecia, mental retardation and electrocardiographic abnormalities
  • Idiopathic premature ovarian failure
  • Incipient ovarian failure
  • Induced female hypogonadism syndrome
  • Infantile and/or juvenile cataract
  • Infantile cataract
  • Infantilism
  • Intellectual disability, craniofacial dysmorphism, hypogonadism, diabetes mellitus syndrome
  • MacDermot Winter syndrome
  • MEHMO syndrome
  • Menopause ovarian failure
  • Nonsenile cataract
  • Ovarian failure
  • Premature ovarian failure
  • Premature ovarian failure
  • Premature ovarian failure
  • Premature ovarian failure due to autoimmune oophoritis
  • Primary hypogonadism
  • Primary ovarian failure
  • Progressive cerebellar ataxia with hypogonadism
  • Prune belly syndrome
  • Resistant ovary syndrome
  • Retinitis pigmentosa, intellectual disability, deafness, hypogenitalism syndrome
  • Sclerosing dysplasia of bone, ichthyosis, premature ovarian failure syndrome
  • Secondary ovarian failure
  • X-linked intellectual disability, hypogonadism, ichthyosis, obesity, short stature syndrome

Diagnostic Related Groups

The ICD-10 code E28.39 is grouped in the following groups for version MS-DRG V37.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2019 through 09/30/2020.


Convert E28.39 to ICD-9

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Disorders of other endocrine glands (E20-E35)
      • Ovarian dysfunction (E28)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients

Ovarian Disorders

The ovaries are part of the female reproductive system. Women have two ovaries, one on each side of the uterus. Each ovary is about the size and shape of an almond.

The ovaries produce and store a woman's eggs. During ovulation, an ovary releases an egg. If that egg is fertilized by a sperm, a pregnancy can occur. Ovaries also make the female hormones estrogen and progesterone. When a woman goes through menopause, her ovaries stop making those hormones and releasing eggs.

Problems with the ovaries include

  • Ovarian cancer
  • Ovarian cysts and polycystic ovary syndrome
  • Primary ovarian insufficiency
  • Ovarian torsion, a twisting of the ovary

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