2026 ICD-10-CM Diagnosis Code E28.0Estrogen excess

ICD-10-CM Codes›E00–E89›E20-E35›E28

ICD-10-CM E28.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E28.0 is a billable ICD-10-CM diagnosis code for estrogen excess. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 742 through 743, 760 through 761. Coders also document this condition as estrogen level above reference range. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E28.0
Billable Status
Yes — Valid for Submission
Code Describes
Estrogen excess
Short Description
Estrogen excess
Same as the full description in the CMS dataset.
Parent Code
E28
Ovarian dysfunction

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE28Ovarian dysfunction
This CodeE28.0Estrogen excess

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Estrogen level above reference range
  • Hyperestrogenism

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • code for adverse effect, if applicable, to identify drug T36 T50

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Excess, excessive, excessively
      • estrogen
    • Hyperestrogenism(drug-induced) (iatrogenic)
    • Hypersecretion
      • estrogen
    • Increase, increased
      • estrogen
    • Puberty(development state)
      • precocious (constitutional) (cryptogenic) (idiopathic)
        • due to
          • ovarian hyperfunction
            • estrogen

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Ovarian Disorders

The ovaries are a pair of female reproductive glands that make eggs and female hormones. Women have one ovary on each side of the uterus (where a fetus grows during pregnancy). Each ovary is about the size and shape of an almond.

The full article covers:

  • What are ovaries?
  • What are the types of ovarian disorders?
  • What causes ovarian disorders?
  • What are the symptoms of ovarian disorders?
  • How are ovarian disorders diagnosed?
  • What are the treatments for ovarian disorders?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E28.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
256.0 Hyperestrogenism
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E28.0Overview

Is E28.0 (Ovarian dysfunction) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report estrogen excess on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E28.0 group to?

When estrogen excess is the principal diagnosis on an inpatient stay, it groups to MS-DRG 742, 743, 760, 761, with relative weights from 0.5696 to 1.8348 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E28.0?

Under the General Equivalence Mappings, estrogen excess converts to ICD-9-CM 256.0 (hyperestrogenism). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.