2027 ICD-10-CM Diagnosis Code E28.0Estrogen excess

ICD-10-CM Codes›E00–E89›E20-E35›E28

ICD-10-CM E28.0
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E28.0 is a billable ICD-10-CM diagnosis code for estrogen excess. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 742 through 743, 760 through 761. Coders also document this condition as estrogen level above reference range. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E28.0
Billable Status
Yes — Valid for Submission
Code Describes
Estrogen excess
Short Description
Estrogen excess
Same as the full description in the CMS dataset.
Parent Code
E28
Ovarian dysfunction

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE28Ovarian dysfunction
This CodeE28.0Estrogen excess

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Estrogen level above reference range
  • Hyperestrogenism

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E28.0: its own notes plus those printed at E28, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E28 Ovarian dysfunction applies to 8 codes
  • isolated gonadotropin deficiency (E23.0)
  • postprocedural ovarian failure (E89.4-)
From Block E20-E35 Disorders of other endocrine glands applies to 99 codes
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E28.0, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming E28.0: they are not reported together with it, unless the two conditions are unrelated.

  • N91 Absent, scanty and rare menstruation
    ovarian dysfunction (E28.-) names E28.-, which includes this code

Code First 1

These codes say to code first a condition named in the note, and E28.0 is one of the conditions named.

  • G63 Polyneuropathy in diseases classified elsewhere
    endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34) names E20-E34, which includes this code

Notes 1

These notes mention E28.0.

  • Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases
    All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hyperestrogenism

    abnormally high level of estrogen.

Patient EducationClinical

Ovarian Disorders

The ovaries are a pair of female reproductive glands that make eggs and female hormones. Women have one ovary on each side of the uterus (where a fetus grows during pregnancy). Each ovary is about the size and shape of an almond.

The full article covers:

  • What are ovaries?
  • What are the types of ovarian disorders?
  • What causes ovarian disorders?
  • What are the symptoms of ovarian disorders?
  • How are ovarian disorders diagnosed?
  • What are the treatments for ovarian disorders?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E28.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
256.0 Hyperestrogenism
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E28.0Overview

What is the ICD-10 code for estrogen excess?

The ICD-10-CM code for estrogen excess is E28.0 (sometimes written as E280). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E28.0 (Ovarian dysfunction) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report estrogen excess on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E28.0 group to?

When estrogen excess is the principal diagnosis on an inpatient stay, it groups to MS-DRG 742, 743, 760, 761, with relative weights from 0.7039 to 1.8448 depending on complications. Higher weights mean higher Medicare reimbursement.

Can E28.0 be reported with E23.0?

Not as a rule. The Excludes1 note at E28, which applies to E28.0, lists "isolated gonadotropin deficiency (E23.0)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does E28.0 need an additional code?

When the condition applies, yes. The Use Additional Code note reads: code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5). The additional code is reported after E28.0.