ICD-10-CM Code E27.49

Other adrenocortical insufficiency

Version 2021 Billable Code

Valid for Submission

E27.49 is a billable code used to specify a medical diagnosis of other adrenocortical insufficiency. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code E27.49 might also be used to specify conditions or terms like achalasia of esophagus, acth deficiency, adrenal atrophy, adrenal calcification, adrenal gland hematoma, adrenal hemorrhage, etc

Short Description:Other adrenocortical insufficiency
Long Description:Other adrenocortical insufficiency

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code E27.49:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Adrenal hemorrhage
  • Adrenal infarction

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code E27.49 are found in the index:


The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Achalasia of esophagus
  • ACTH deficiency
  • Adrenal atrophy
  • Adrenal calcification
  • Adrenal gland hematoma
  • Adrenal hemorrhage
  • Adrenal infarction
  • Adrenal insufficiency due to adrenal metastasis
  • Adrenal necrosis
  • Adrenocortical hemorrhage
  • Aldosterone deficiency
  • Aldosterone deficiency
  • Aldosterone deficiency
  • Congenital achalasia of esophagus
  • Familial hypoaldosteronism
  • Generalized glucocorticoid resistance syndrome
  • Glucocorticoid deficiency with achalasia
  • Hereditary glucocorticoid resistance
  • Hyperkalemic renal tubular acidosis
  • Hyperreninemic hypoaldosteronism
  • Hypocortisolism secondary to another disorder
  • Hyporeninemic hypoaldosteronism
  • Isolated corticotropin deficiency
  • Mineralocorticoid deficiency

Clinical Information

  • ADDISON DISEASE-. an adrenal disease characterized by the progressive destruction of the adrenal cortex resulting in insufficient production of aldosterone and hydrocortisone. clinical symptoms include anorexia; nausea; weight loss; muscle weakness; and hyperpigmentation of the skin due to increase in circulating levels of acth precursor hormone which stimulates melanocytes.

Diagnostic Related Groups

The ICD-10 code E27.49 is grouped in the following groups for version MS-DRG V38.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2021.


Convert E27.49 to ICD-9

  • 255.41 - Glucocorticoid deficient (Approximate Flag)
  • 255.42 - Mineralcorticoid defcnt (Approximate Flag)

Code Classification

  • Endocrine, nutritional and metabolic diseases (E00–E90)
    • Disorders of other endocrine glands (E20-E35)
      • Other disorders of adrenal gland (E27)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Information for Patients

Addison Disease

Also called: Adrenal insufficiency, Adrenocortical hypofunction, Hypocortisolism

Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.

A problem with your immune system usually causes Addison disease. The immune system mistakenly attacks your own tissues, damaging your adrenal glands. Other causes include infections and cancer.

Symptoms include

  • Weight loss
  • Muscle weakness
  • Fatigue that gets worse over time
  • Low blood pressure
  • Patchy or dark skin

Lab tests can confirm that you have Addison disease. If you don't treat it, it can be fatal. You will need to take hormone pills for the rest of your life. If you have Addison disease, you should carry an emergency ID. It should say that you have the disease, list your medicines and say how much you need in an emergency.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

  • ACTH (cosyntropin) stimulation test (Medical Encyclopedia)
  • ACTH blood test (Medical Encyclopedia)
  • Acute adrenal crisis (Medical Encyclopedia)
  • Addison disease (Medical Encyclopedia)
  • Cortisol level (Medical Encyclopedia)

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