2027 ICD-10-CM Diagnosis Code E27.8Other specified disorders of adrenal gland
ICD-10-CM Codes›E00–E89›E20-E35›E27
- Billable — Valid for Submission
- Chronic Condition
E27.8 is a billable ICD-10-CM diagnosis code for other specified disorders of adrenal gland. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.
E27.8 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E27.8 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Abnormality of cortisol-binding globulin
- Adrenal cyst
- Adrenal edema
- Adrenal gland cytomegaly
- Adrenal hyperplasia
- Adrenocortical hyperplasia
- Aldosterone disorder
- Benign neoplasm of heart
- Bilateral mass of adrenal glands
- Capsular extrusion of adrenal cortex
- Carney complex
- Carney complex-associated-primary pigmented nodular adrenocortical disease
- Corticosteroid-binding globulin deficiency
- Cortisol binding globulin high
- Cortisol binding globulin low
- Cushing syndrome due to bilateral adrenocortical hyperplasia
- Degeneration of adrenal gland
- Disorder of cortisol-cortisone shuttle
- Endocrine disorder related to puberty
- Enlarged adrenal gland
- Fibrosis of adrenal gland
- Generalized glucocorticoid resistance syndrome
- Hyperaldosteronism with nodular hyperplasia of adrenal cortex
- Hypercortisolism due to macronodular adrenal hyperplasia
- Hypertrophy of adrenal gland
- Inflammation of adrenal gland
- Isolated micronodular adrenocortical disease
- Isolated primary pigmented nodular adrenocortical disease
- Macronodular adrenal hyperplasia
- Mass of left adrenal gland
- Mass of right adrenal gland
- Micronodular adrenal hyperplasia
- Myxoma of heart
- Nodular hyperplasia of adrenal cortex
- Nodule of adrenal cortex
- Polyglandular hyperfunction
- Precocious puberty due to adrenal hyperplasia
- Primary unilateral adrenal hyperplasia
- Sclerosis of adrenal gland
- Small adrenal gland
- Suppression of adrenal gland
- Syndrome of apparent mineralocorticoid excess
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E27.8: its own notes plus those printed at block E20-E35 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Abnormality of cortisol-binding globulin
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E27.8, its category, or a range that includes it.
Code First 1
These codes say to code first a condition named in the note, and E27.8 is one of the conditions named.
- G63 Polyneuropathy in diseases classified elsewhere
Notes 1
These notes mention E27.8.
- Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseasesAll neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Abnormal, abnormality, abnormalities See Also: Anomaly;
cortisol-binding E27.8
Abscess (connective tissue) (embolic) (fistulous) (infective) (metastatic) (multiple) (pernicious) (pyogenic) (septic) L02.91
Adrenalitis, adrenitis E27.8
Disease, diseased See Also: Syndrome;
Disorder (of) See Also: Disease;
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Adrenal Gland Disorders
Your adrenal glands are two small organs that sit on top of each kidney. The adrenal glands make different types of hormones you need to stay alive and healthy. Hormones are chemicals that travel in your bloodstream and control how different parts of your body work.
The full article covers:
- What are adrenal glands?
- What are adrenal gland disorders?
- What causes adrenal gland disorders?
- How are adrenal gland disorders diagnosed?
- What are the treatments for adrenal gland disorders?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E27.8 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E27.8Overview
What is the ICD-10 code for other specified disorders of adrenal gland?
The ICD-10-CM code for other specified disorders of adrenal gland is E27.8 (sometimes written as E278). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E27.8 (Other disorders of adrenal gland) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other specified disorders of adrenal gland on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E27.8 group to?
When other specified disorders of adrenal gland is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.
Can E27.8 be reported with N64.3?
Not as a rule. The Excludes1 note at block E20-E35, which applies to E27.8, lists "galactorrhea (N64.3)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of E27.8?
Under the General Equivalence Mappings, other specified disorders of adrenal gland converts to ICD-9-CM 255.8 (adrenal disorder NEC). The mapping is approximate, so confirm the match fits the documentation.
Does E27.8 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. E27.8 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).
