2026 ICD-10-CM Diagnosis Code E27.8Other specified disorders of adrenal gland

ICD-10-CM Codes›E00–E89›E20-E35›E27

ICD-10-CM E27.8
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E27.8 is a billable ICD-10-CM diagnosis code for other specified disorders of adrenal gland. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E27.8
Billable Status
Yes — Valid for Submission
Code Describes
Other specified disorders of adrenal gland
Short Description
Other specified disorders of adrenal gland
Same as the full description in the CMS dataset.
Parent Code
E27
Other disorders of adrenal gland

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE27Other disorders of adrenal gland
This CodeE27.8Other specified disorders of adrenal gland

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Abnormality of cortisol-binding globulin
  • Adrenal cyst
  • Adrenal edema
  • Adrenal gland cytomegaly
  • Adrenal hyperplasia
  • Adrenocortical hyperplasia
  • Aldosterone disorder
  • Benign neoplasm of heart
  • Bilateral mass of adrenal glands
  • Capsular extrusion of adrenal cortex
  • Carney complex
  • Carney complex-associated-primary pigmented nodular adrenocortical disease
  • Corticosteroid-binding globulin deficiency
  • Cortisol binding globulin high
  • Cortisol binding globulin low
  • Cushing syndrome due to bilateral adrenocortical hyperplasia
  • Degeneration of adrenal gland
  • Disorder of cortisol-cortisone shuttle
  • Endocrine disorder related to puberty
  • Enlarged adrenal gland
  • Fibrosis of adrenal gland
  • Generalized glucocorticoid resistance syndrome
  • Hyperaldosteronism with nodular hyperplasia of adrenal cortex
  • Hypercortisolism due to macronodular adrenal hyperplasia
  • Hypertrophy of adrenal gland
  • Inflammation of adrenal gland
  • Isolated micronodular adrenocortical disease
  • Isolated primary pigmented nodular adrenocortical disease
  • Macronodular adrenal hyperplasia
  • Mass of left adrenal gland
  • Mass of right adrenal gland
  • Micronodular adrenal hyperplasia
  • Myxoma of heart
  • Nodular hyperplasia of adrenal cortex
  • Nodule of adrenal cortex
  • Polyglandular hyperfunction
  • Precocious puberty with adrenal hyperplasia
  • Primary unilateral adrenal hyperplasia
  • Sclerosis of adrenal gland
  • Small adrenal gland
  • Suppression of adrenal gland
  • Syndrome of apparent mineralocorticoid excess

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Abnormality of cortisol-binding globulin

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Abnormal, abnormality, abnormalities
      • cortisol-binding globulin
    • Abnormal, abnormality, abnormalities
      • globulin
        • cortisol-binding
    • Abscess(connective tissue) (embolic) (fistulous) (infective) (metastatic) (multiple) (pernicious) (pyogenic) (septic)
      • adrenal (capsule) (gland)
    • Abscess(connective tissue) (embolic) (fistulous) (infective) (metastatic) (multiple) (pernicious) (pyogenic) (septic)
      • suprarenal (capsule) (gland)
    • Adrenalitis, adrenitis
    • Cyst(colloid) (mucous) (simple) (retention)
      • adrenal gland
    • Cyst(colloid) (mucous) (simple) (retention)
      • suprarenal gland
    • Degeneration, degenerative
      • adrenal (capsule) (fatty) (gland) (hyaline) (infectional)
    • Degeneration, degenerative
      • suprarenal (capsule) (gland)
    • Disease, diseased
      • adrenal (capsule) (cortex) (gland) (medullary)
        • specified NEC
    • Disease, diseased
      • suprarenal (capsule) (gland)
        • specified NEC
    • Disorder(of)
      • adrenal (capsule) (gland) (medullary)
        • specified NEC
    • Fibrosis, fibrotic
      • adrenal (gland)
    • Hemorrhage, hemorrhagic(concealed)
      • adrenal (capsule) (gland)
        • medulla
    • Hyperplasia, hyperplastic
      • adrenal (capsule) (cortex) (gland)
    • Hyperplasia, hyperplastic
      • suprarenal capsule (gland)
    • Hypertrophy, hypertrophic
      • adrenal cortex
    • Hypertrophy, hypertrophic
      • suprarenal cortex (gland)
    • Inflammation, inflamed, inflammatory(with exudation)
      • adrenal (gland)
    • Inflammation, inflamed, inflammatory(with exudation)
      • suprarenal (gland)
    • Obesity
      • adrenal
    • Sclerosis, sclerotic
      • adrenal (gland)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Carney Complex

    autosomal dominant syndrome characterized by cardiac and cutaneous myxomas; lentiginosis (spotty pigmentation of the skin), and endocrinopathy and its associated endocrine tumors. the cardiac myxomas may lead to sudden cardiac death and other complications in carney complex patients. the gene coding for the prkar1a protein is one of the causative genetic loci (type 1). a second locus is at chromosome 2p16 (type 2).

  • Syndrome of Apparent Mineralocorticoid Excess

    an autosomal recessive disorder caused by a deficiency of 11-beta-hydroxysteroid dehydrogenase, which is characterized by hypertension, hypokalemia, low renin, and hypoaldosteronism.

  • Adrenal Cyst

    a cyst located in the adrenal gland.

Patient EducationClinical

Adrenal Gland Disorders

Your adrenal glands are two small organs that sit on top of each kidney. The adrenal glands make different types of hormones you need to stay alive and healthy. Hormones are chemicals that travel in your bloodstream and control how different parts of your body work.

The full article covers:

  • What are adrenal glands?
  • What are adrenal gland disorders?
  • What causes adrenal gland disorders?
  • How are adrenal gland disorders diagnosed?
  • What are the treatments for adrenal gland disorders?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E27.8 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
255.8 Adrenal disorder NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E27.8Overview

Is E27.8 (Other disorders of adrenal gland) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other specified disorders of adrenal gland on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E27.8 group to?

When other specified disorders of adrenal gland is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E27.8?

Under the General Equivalence Mappings, other specified disorders of adrenal gland converts to ICD-9-CM 255.8 (adrenal disorder NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.