2027 ICD-10-CM Diagnosis Code E88.02Plasminogen deficiency

ICD-10-CM Codes›E00–E89›E70-E88›E88

ICD-10-CM E88.02
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E88.02 is a billable ICD-10-CM diagnosis code for plasminogen deficiency. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 826 through 830, 843 through 845. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 136 closely related codes. Coders also document this condition as dysplasminogenemia. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
E88.02
Billable Status
Yes — Valid for Submission
Code Describes
Plasminogen deficiency
Short Description
Plasminogen deficiency
Same as the full description in the CMS dataset.
Parent Code
E88.0
Disorders of plasma-protein metabolism, not elsewhere classified

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE70-E88Metabolic disorders
CategoryE88Other and unspecified metabolic disorders
This CodeE88.02Plasminogen deficiency

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Dysplasminogenemia
  • Fibrinolytic bleeding syndrome
  • Hypoplasminogenemia

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E88.02: its own notes plus those printed at E88.0, E88, block E70-E88, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Dysplasminogenemia
  • Hypoplasminogenemia
  • Type 1 plasminogen deficiency
  • Type 2 plasminogen deficiency

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E88.0 Disorders of plasma-protein metabolism, not elsewhere classified applies to 3 codes
  • monoclonal gammopathy (of undetermined significance) (D47.2)
  • polyclonal hypergammaglobulinemia (D89.0)
  • Waldenström macroglobulinemia (C88.00)
From E88 Other and unspecified metabolic disorders applies to 24 codes
  • histiocytosis X (chronic) (C96.6)
From Block E70-E88 Metabolic disorders applies to 286 codes
  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From E88.0 Disorders of plasma-protein metabolism, not elsewhere classified applies to 3 codes
  • disorder of lipoprotein metabolism (E78.-)
From Block E70-E88 Metabolic disorders applies to 286 codes
  • Ehlers-Danlos syndromes (Q79.6-)

Use Additional Code

Add a second code, after this one, to fully describe the condition.

On E88.02 itself
  • code for associated findings, such as:
  • hydrocephalus (G91.4)
  • otitis media (H67.-)
  • respiratory disorder related to plasminogen deficiency (J99)
From E88 Other and unspecified metabolic disorders applies to 24 codes
  • codes for associated conditions

Code Also

A second code may be needed to fully describe the condition; the note gives no sequencing direction.

  • if applicable, ligneous conjunctivitis (H10.51-)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E88.02, its category, or a range that includes it.

Excludes1 1

These codes carry an Excludes1 note naming E88.02: they are not reported together with it, unless the two conditions are unrelated.

  • R77 Other abnormalities of plasma proteins
    disorders of plasma-protein metabolism (E88.0-) names E88.0-, which includes this code

Code First 3

These codes say to code first a condition named in the note, and E88.02 is one of the conditions named.

  • G91.4 Hydrocephalus in diseases classified elsewhere
    plasminogen deficiency (E88.02)
  • H67 Otitis media in diseases classified elsewhere
    plasminogen deficiency (E88.02)
  • J99 Respiratory disorders in diseases classified elsewhere
    plasminogen deficiency (E88.02)

Code Also 1

These codes say E88.02 may also be needed to fully describe the condition. The note gives no sequencing direction.

  • H10.51 Ligneous conjunctivitis
    plasminogen deficiency (E88.02)

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Bleeding Disorders

Normally, if you get hurt, your body forms a blood clot to stop the bleeding. For blood to clot, your body needs cells called platelets and proteins known as clotting factors. If you have a bleeding disorder, you either do not have enough platelets or clotting factors or they don't work the way they should.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement E88.02 replaces the following previously assigned code(s):

  • E88.09 - Oth disorders of plasma-protein metabolism, NEC
FY 2019AddedAdded to the ICD-10-CM code setEffective October 1, 2018.
FY 2020–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E88.02Overview

What is the ICD-10 code for plasminogen deficiency?

The ICD-10-CM code for plasminogen deficiency is E88.02 (sometimes written as E8802). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E88.02 a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report plasminogen deficiency on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E88.02 group to?

When plasminogen deficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 844, 827, 829, 843, 828, 826, 830, 845, with relative weights from 0.8443 to 4.7560 depending on complications. Higher weights mean higher Medicare reimbursement.

Is E88.02 a CC or MCC?

CMS lists E88.02 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 136 closely related codes in its exclusion list.

Can E88.02 be reported with D47.2?

Not as a rule. The Excludes1 note at E88.0, which applies to E88.02, lists "monoclonal gammopathy (of undetermined significance) (D47.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).