2026 ICD-10-CM Diagnosis Code E27.3Drug-induced adrenocortical insufficiency

ICD-10-CM Codes›E00–E89›E20-E35›E27

ICD-10-CM E27.3
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E27.3 is a billable ICD-10-CM diagnosis code for drug-induced adrenocortical insufficiency. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. Coders also document this condition as ACTH deficiency. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Drug induced or toxic related condition and Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E27.3
Billable Status
Yes — Valid for Submission
Code Describes
Drug-induced adrenocortical insufficiency
Short Description
Drug-induced adrenocortical insufficiency
Same as the full description in the CMS dataset.
Parent Code
E27
Other disorders of adrenal gland

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE27Other disorders of adrenal gland
This CodeE27.3Drug-induced adrenocortical insufficiency

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • ACTH deficiency
  • Drug-induced adrenocortical insufficiency
  • Iatrogenic adrenal insufficiency
  • Steroid suppression of ACTH secretion

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Use Additional Code

  • code for adverse effect, if applicable, to identify drug T36 T50

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Hypofunction
      • adrenocortical
        • drug-induced
    • Insufficiency, insufficient
      • adrenocortical
        • drug-induced
    • Insufficiency, insufficient
      • adrenocortical
        • iatrogenic
    • Steroid
      • effects (adverse) (adrenocortical) (iatrogenic)
        • insufficiency

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR INJ030
Drug induced or toxic related condition
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Addison Disease

Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E27.3 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
255.41 Glucocorticoid deficient
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E27.3Overview

Is E27.3 (Other disorders of adrenal gland) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report drug-induced adrenocortical insufficiency on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E27.3 group to?

When drug-induced adrenocortical insufficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E27.3?

Under the General Equivalence Mappings, drug-induced adrenocortical insufficiency converts to ICD-9-CM 255.41 (glucocorticoid deficient). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.