2027 ICD-10-CM Diagnosis Code E27.1Primary adrenocortical insufficiency
ICD-10-CM Codes›E00–E89›E20-E35›E27
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 51
- Chronic Condition
E27.1 is a billable ICD-10-CM diagnosis code for primary adrenocortical insufficiency. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 22 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.
For Medicare Advantage risk adjustment, E27.1 maps to CMS-HCC Category 51 (Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders) under the V28 model, adding a risk factor of about 0.510 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E27.1 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Addison's disease
- Addison's disease due to autoimmunity
- Adrenocorticotropic hormone resistance syndrome
- Adrenomyodystrophy
- Buccal pigmentation due to Addison's disease
- Congenital hypoplasia of adrenal gland
- Congenital primary adrenocortical hypofunction
- Endocrine myopathy
- Familial glucocorticoid deficiency
- Familial steroid-resistant nephrotic syndrome with adrenal insufficiency
- Hereditary adrenal unresponsiveness to corticotropin
- Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency
- Melanin pigmentation of oral mucosa
- Melanosis of mucosa of body orifice
- Myopathy in Addison's disease
- Pituitary thyroid hormone resistance
- Primary adrenocortical insufficiency
- Primary immunodeficiency with natural killer cell deficiency and adrenal insufficiency
- Resistance to thyroid hormone syndrome
- Steroid-resistant nephrotic syndrome
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E27.1: its own notes plus those printed at block E20-E35 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Addison's disease
- Autoimmune adrenalitis
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E27.1, its category, or a range that includes it.
Code First 1
These codes say to code first a condition named in the note, and E27.1 is one of the conditions named.
- G63 Polyneuropathy in diseases classified elsewhere
Notes 1
These notes mention E27.1.
- Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseasesAll neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disease, diseased See Also: Syndrome;
bronze Addison's E27.1
primary E27.1
addisonian E27.1
adrenal E27.1
suprarenal E27.1
adrenal (gland) E27.1
suprarenal (gland) E27.1
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Addison Disease
an adrenal disease characterized by the progressive destruction of the adrenal cortex, resulting in insufficient production of aldosterone and hydrocortisone. clinical symptoms include anorexia; nausea; weight loss; muscle weakness; and hyperpigmentation of the skin due to increase in circulating levels of acth precursor hormone which stimulates melanocytes.
Patient EducationClinical
Addison Disease
Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E27.1 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E27.1Overview
What is the ICD-10 code for primary adrenocortical insufficiency?
The ICD-10-CM code for primary adrenocortical insufficiency is E27.1 (sometimes written as E271). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E27.1 (Other disorders of adrenal gland) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report primary adrenocortical insufficiency on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E27.1 group to?
When primary adrenocortical insufficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.
Is E27.1 a CC or MCC?
CMS lists E27.1 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 22 closely related codes in its exclusion list.
Can E27.1 be reported with E71.528?
Not as a rule. The Excludes1 note on E27.1 lists "Addison only phenotype adrenoleukodystrophy (E71.528)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What HCC is E27.1?
E27.1 (primary adrenocortical insufficiency) maps to CMS-HCC Category 51 (Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders), commonly written as HCC 51, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 23 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 43.
Does E27.1 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, E27.1 adds a risk adjustment factor of about 0.510 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.313 to 0.654 depending on the payment segment). HCC 51 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 51 category page.
