2026 ICD-10-CM Diagnosis Code E27.1Primary adrenocortical insufficiency

ICD-10-CM Codes›E00–E89›E20-E35›E27

ICD-10-CM E27.1
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E27.1 is a billable ICD-10-CM diagnosis code for primary adrenocortical insufficiency. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E27.1
Billable Status
Yes — Valid for Submission
Code Describes
Primary adrenocortical insufficiency
Short Description
Primary adrenocortical insufficiency
Same as the full description in the CMS dataset.
Parent Code
E27
Other disorders of adrenal gland

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE27Other disorders of adrenal gland
This CodeE27.1Primary adrenocortical insufficiency

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Addison's disease
  • Addison's disease due to autoimmunity
  • Adrenocorticotropic hormone resistance syndrome
  • Adrenomyodystrophy
  • Buccal pigmentation due to Addison's disease
  • Congenital hypoplasia of adrenal gland
  • Congenital primary adrenocortical hypofunction
  • Endocrine myopathy
  • Familial glucocorticoid deficiency
  • Familial steroid-resistant nephrotic syndrome with adrenal insufficiency
  • Hereditary adrenal unresponsiveness to corticotropin
  • Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency
  • Melanin pigmentation of oral mucosa
  • Melanosis of mucosa of body orifice
  • Myopathy in Addison's disease
  • Pituitary thyroid hormone resistance
  • Primary adrenocortical insufficiency
  • Primary immunodeficiency with natural killer cell deficiency and adrenal insufficiency
  • Resistance to thyroid hormone syndrome
  • Steroid-resistant nephrotic syndrome

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Addison's disease
  • Autoimmune adrenalitis

Type 1 Excludes

  • Addison only phenotype adrenoleukodystrophy E71.528
  • amyloidosis E85
  • tuberculous Addison's disease A18.7
  • Waterhouse-Friderichsen syndrome A39.1

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Addison's
      • disease (bronze) or syndrome
    • Adrenalitis, adrenitis
      • autoimmune
    • Atrophy, atrophic(of)
      • adrenal (capsule) (gland)
        • primary (autoimmune)
    • Atrophy, atrophic(of)
      • suprarenal (capsule) (gland)
        • primary
    • Deficiency, deficient
      • corticoadrenal
        • primary
    • Disease, diseased
      • bronze Addison's
    • Hypoadrenalism, hypoadrenia
      • primary
    • Hypoadrenocorticism
      • primary
    • Hypofunction
      • adrenocortical
        • primary
    • Insufficiency, insufficient
      • adrenal (gland)
        • primary
    • Insufficiency, insufficient
      • adrenocortical
        • primary
    • Insufficiency, insufficient
      • corticoadrenal
        • primary
    • Insufficiency, insufficient
      • suprarenal
        • primary
    • Melanosis
      • addisonian
    • Melanosis
      • adrenal
    • Melanosis
      • suprarenal
    • Melasma
      • adrenal (gland)
    • Melasma
      • suprarenal (gland)
    • Myopathy
      • in (due to)
        • Addison's disease

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Addison Disease

Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E27.1 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
255.41 Glucocorticoid deficient
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E27.1Overview

Is E27.1 (Other disorders of adrenal gland) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report primary adrenocortical insufficiency on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E27.1 group to?

When primary adrenocortical insufficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E27.1?

Under the General Equivalence Mappings, primary adrenocortical insufficiency converts to ICD-9-CM 255.41 (glucocorticoid deficient). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.