2026 ICD-10-CM Diagnosis Code E27.0Other adrenocortical overactivity

ICD-10-CM Codes›E00–E89›E20-E35›E27

ICD-10-CM E27.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E27.0 is a billable ICD-10-CM diagnosis code for other adrenocortical overactivity. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E27.0
Billable Status
Yes — Valid for Submission
Code Describes
Other adrenocortical overactivity
Short Description
Other adrenocortical overactivity
Same as the full description in the CMS dataset.
Parent Code
E27
Other disorders of adrenal gland

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE27Other disorders of adrenal gland
This CodeE27.0Other adrenocortical overactivity

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Acquired adrenogenital syndrome
  • Acquired benign adrenal androgenic overactivity
  • ACTH hypersecretion
  • ACTH hypersecretion not causing Cushing's syndrome
  • Adrenal hyperfunction
  • Adrenal virilism
  • Adrenarche
  • Adrenocortical hyperfunction
  • Endocrine disorder related to puberty
  • Precocious puberty with adrenocortical hyperfunction
  • Premature adrenarche
  • Pseudo-Cushing's syndrome
  • Pseudo-Cushing's syndrome of depression

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Overproduction of ACTH, not associated with Cushing's disease
  • Premature adrenarche

Type 1 Excludes

  • Cushing's syndrome E24

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Adrenarche, premature
    • Disease, diseased
      • adrenal (capsule) (cortex) (gland) (medullary)
        • hyperfunction
    • Disease, diseased
      • suprarenal (capsule) (gland)
        • hyperfunction
    • Dysadrenocortism
      • hyperfunction
    • Dysfunction
      • adrenal
        • hyperfunction
    • Dysfunction
      • suprarenal
        • hyperfunction
    • Hyperadrenocorticism
      • not associated with Cushing's syndrome
    • Hyperfunction
      • adrenal cortex, not associated with Cushing's syndrome
    • Hypersecretion
      • ACTH (not associated with Cushing's syndrome)
    • Hypersecretion
      • hormone (s)
        • ACTH (not associated with Cushing's syndrome)
    • Overactive
      • adrenal cortex NEC
    • Overproduction
      • ACTH
    • Premature
      • adrenarche
    • Schroeder's syndrome(endocrine hypertensive)
    • Slocumb's syndrome
    • Syndrome
      • endocrine-hypertensive
    • Syndrome
      • Schroeder's
    • Syndrome
      • Slocumb's
    • Syndrome
      • suprarenal cortical

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Adrenarche

    a stage of development at which the adrenal glands undergo maturation leading to the capability of producing increasing amounts of adrenal androgens, dehydroepiandrosterone and androstenedione. adrenarche usually begins at about 7 or 8 years of age before the signs of puberty and continues throughout puberty.

  • Adrenocortical Hyperfunction

    excess production of adrenal cortex hormones such as aldosterone; hydrocortisone; dehydroepiandrosterone; and/or androstenedione. hyperadrenal syndromes include cushing syndrome; hyperaldosteronism; and virilism.

  • Premature Adrenarche

    premature onset of adrenal androgen-mediated secondary sexual characteristics.

Patient EducationClinical

Adrenal Gland Disorders

Your adrenal glands are two small organs that sit on top of each kidney. The adrenal glands make different types of hormones you need to stay alive and healthy. Hormones are chemicals that travel in your bloodstream and control how different parts of your body work.

The full article covers:

  • What are adrenal glands?
  • What are adrenal gland disorders?
  • What causes adrenal gland disorders?
  • How are adrenal gland disorders diagnosed?
  • What are the treatments for adrenal gland disorders?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E27.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
255.3 Corticoadren overact NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E27.0Overview

Is E27.0 (Other disorders of adrenal gland) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other adrenocortical overactivity on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E27.0 group to?

When other adrenocortical overactivity is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E27.0?

Under the General Equivalence Mappings, other adrenocortical overactivity converts to ICD-9-CM 255.3 (corticoadren overact NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.