2027 ICD-10-CM Diagnosis Code E27.0Other adrenocortical overactivity
ICD-10-CM Codes›E00–E89›E20-E35›E27
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Chronic Condition
E27.0 is a billable ICD-10-CM diagnosis code for other adrenocortical overactivity. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 22 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.
E27.0 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E27.0 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acquired adrenogenital syndrome
- Acquired benign adrenal androgenic overactivity
- ACTH hypersecretion
- ACTH hypersecretion not causing Cushing's syndrome
- Adrenal hyperfunction
- Adrenal virilism
- Adrenarche
- Adrenocortical hyperfunction
- Endocrine disorder related to puberty
- Precocious puberty due to adrenocortical hyperfunction
- Premature adrenarche
- Pseudo-Cushing's syndrome
- Pseudo-Cushing's syndrome of depression
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E27.0: its own notes plus those printed at block E20-E35 and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Overproduction of ACTH, not associated with Cushing's disease
- Premature adrenarche
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- Cushing's syndrome (E24.-)
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E27.0, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming E27.0: they are not reported together with it, unless the two conditions are unrelated.
- E22 Hyperfunction of pituitary glandoverproduction of ACTH not associated with Cushing's disease (E27.0)
Code First 1
These codes say to code first a condition named in the note, and E27.0 is one of the conditions named.
- G63 Polyneuropathy in diseases classified elsewhere
Notes 1
These notes mention E27.0.
- Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseasesAll neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Adrenarche, premature E27.0
Disease, diseased See Also: Syndrome;
hyperfunction E27.0
hyperfunction E27.0
Overactive See Also: Hyperfunction;
adrenal cortex NEC E27.0
Overproduction See Also: Hypersecretion;
ACTH E27.0
Premature See Also: condition;
adrenarche E27.0
Slocumb's syndrome E27.0
Syndrome See Also: Disease;
endocrine-hypertensive E27.0
Schroeder's E27.0
Slocumb's E27.0
suprarenal cortical E27.0
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Adrenal Gland Disorders
Your adrenal glands are two small organs that sit on top of each kidney. The adrenal glands make different types of hormones you need to stay alive and healthy. Hormones are chemicals that travel in your bloodstream and control how different parts of your body work.
The full article covers:
- What are adrenal glands?
- What are adrenal gland disorders?
- What causes adrenal gland disorders?
- How are adrenal gland disorders diagnosed?
- What are the treatments for adrenal gland disorders?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E27.0 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E27.0Overview
What is the ICD-10 code for other adrenocortical overactivity?
The ICD-10-CM code for other adrenocortical overactivity is E27.0 (sometimes written as E270). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E27.0 (Other disorders of adrenal gland) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report other adrenocortical overactivity on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E27.0 group to?
When other adrenocortical overactivity is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.
Is E27.0 a CC or MCC?
CMS lists E27.0 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 22 closely related codes in its exclusion list.
Can E27.0 be reported with a code from E24?
Not as a rule. The Excludes1 note on E27.0 lists "Cushing's syndrome (E24.-)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
Does E27.0 risk-adjust for Medicare Advantage payment?
Not for Medicare Advantage. E27.0 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).
