2026 ICD-10-CM Diagnosis Code E23.6Other disorders of pituitary gland

ICD-10-CM Codes›E00–E89›E20-E35›E23

ICD-10-CM E23.6
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E23.6 is a billable ICD-10-CM diagnosis code for other disorders of pituitary gland. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Pituitary disorders.

Code Identity

ICD-10-CM Code
E23.6
Billable Status
Yes — Valid for Submission
Code Describes
Other disorders of pituitary gland
Short Description
Other disorders of pituitary gland
Same as the full description in the CMS dataset.
Parent Code
E23
Hypofunction and other disorders of the pituitary gland

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE23Hypofunction and other disorders of the pituitary gland
This CodeE23.6Other disorders of pituitary gland

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Abnormality of neurotensine secretion
  • Abnormality of somatostatin secretion
  • Adenohypophysitis
  • Adiposogenital dystrophy
  • Anterior pituitary hyperplasia
  • Autoimmune hypophysitis
  • Cerebrospinal fluid rhinorrhea
  • Cerebrospinal fluid rhinorrhea due to empty sella syndrome
  • Colloid brain cyst
  • Colloid cyst of pituitary gland
  • Congenital cyst of brain
  • Congenital cyst of cerebrum
  • Corticotroph hyperplasia
  • Cranial cerebrospinal fluid leak
  • Cyst of craniobuccal pouch
  • Diencephalic syndrome
  • Diencephalic syndrome of infancy
  • Disorder of posterior pituitary
  • Empty sella syndrome
  • Endogenous obesity
  • Epidermoid cyst of brain
  • Epidermoid cyst of pituitary gland
  • Excessive thirst
  • Fetal endocrine disorder
  • Fetal malformation of central nervous system
  • Gonadotroph hyperplasia
  • Granulomatous giant-cell hypophysitis
  • Hypoparathyroidism due to impaired PTH secretion
  • Hypophysitis
  • Hypophysitis caused by drug
  • Hypothalamic disorder of appetite
  • Hypothalamic obesity
  • Iatrogenic pituitary disorder
  • Immunoglobulin G4 related disease
  • Immunoglobulin G4 related hypophysitis
  • Infundibulo neurohypophysitis
  • Isolated thyroliberin deficiency
  • Lactotroph hyperplasia
  • Leak of cranial cerebrospinal fluid due to empty sella syndrome
  • Lymphocytic hypophysitis of pregnancy
  • Lymphocytic hypopituitarism
  • Mass of neurohypophysis
  • Necrosis of pituitary
  • Obesity by contributing factors
  • Obesity due to pituitary disease
  • Obesity of endocrine origin
  • Oxytocin deficiency
  • Panhypophysitis
  • Pituitary apoplexy
  • Pituitary cyst
  • Pituitary deficiency due to Rathke cleft cysts
  • Pituitary degeneration
  • Pituitary fibrosis
  • Pituitary fibrosis with midline fibrosis
  • Pituitary gland enlarged
  • Pituitary granuloma
  • Pituitary hemorrhage
  • Pituitary hypertrophy
  • Pituitary infarction
  • Pituitary stalk compression
  • Pituitary stalk compression hyperprolactinemia
  • Postpartum intrapituitary hemorrhage
  • Rathke's pouch cyst
  • Somatotroph hyperplasia
  • Syndrome of diencephalo-hypophyseal origin
  • Thyrotroph hyperplasia
  • Xanthomatous hypophysitis

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Abscess of pituitary
  • Adiposogenital dystrophy

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Abscess(connective tissue) (embolic) (fistulous) (infective) (metastatic) (multiple) (pernicious) (pyogenic) (septic)
      • pituitary (gland)
    • Adiposis
      • cerebralis
    • Adiposogenital dystrophy
    • Cyst(colloid) (mucous) (simple) (retention)
      • craniobuccal pouch
    • Cyst(colloid) (mucous) (simple) (retention)
      • craniopharyngeal pouch
    • Cyst(colloid) (mucous) (simple) (retention)
      • hypophysis, hypophyseal (duct) (recurrent)
    • Cyst(colloid) (mucous) (simple) (retention)
      • hypophysis, hypophyseal (duct) (recurrent)
        • cerebri
    • Cyst(colloid) (mucous) (simple) (retention)
      • intrasellar
    • Cyst(colloid) (mucous) (simple) (retention)
      • pituitary (duct) (gland)
    • Cyst(colloid) (mucous) (simple) (retention)
      • Rathke's pouch
    • Degeneration, degenerative
      • pituitary (gland)
    • Disorder(of)
      • pituitary gland
        • specified NEC
    • Dystrophy, dystrophia
      • adiposogenital
    • Embolism(multiple) (paradoxical)
      • pituitary
    • Fröhlich's syndrome
    • Hemorrhage, hemorrhagic(concealed)
      • pituitary (gland)
    • Hypertrophy, hypertrophic
      • pituitary (anterior) (fossa) (gland)
    • Hypoplasia, hypoplastic
      • genitalia, genital organ (s)
        • in adiposogenital dystrophy
    • Infarct, infarction
      • hypophysis (anterior lobe)
    • Infarct, infarction
      • pituitary (gland)
    • Obesity
      • pituitary
    • Syndrome
      • adiposogenital

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END013
Pituitary disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Pituitary Apoplexy

    the sudden loss of blood supply to the pituitary gland, leading to tissue necrosis and loss of function (panhypopituitarism). the most common cause is hemorrhage or infarction of a pituitary adenoma. it can also result from acute hemorrhage into sella turcica due to head trauma; intracranial hypertension; or other acute effects of central nervous system hemorrhage. clinical signs include severe headache; hypotension; bilateral visual disturbances; unconsciousness; and coma.

  • Autoimmune Hypophysitis

    immune-mediated inflammation of the pituitary gland often associated with other autoimmune diseases (e.g., hashimoto disease; graves disease; and addison disease).

  • Hypophysitis

    inflammation of the pituitary gland.

  • Empty Sella Syndrome

    a condition when the sella turcica is not filled with pituitary tissue. the pituitary gland is either compressed, atrophied, or removed. there are two types: (1) primary empty sella is due a defect in the sella diaphragm leading to arachnoid herniation into the sellar space; (2) secondary empty sella is associated with the removal or treatment of pituitary neoplasms.

  • Cerebrospinal Fluid Rhinorrhea

    discharge of cerebrospinal fluid through the nose. common etiologies include trauma, neoplasms, and prior surgery, although the condition may occur spontaneously. (otolaryngol head neck surg 1997 apr;116(4):442-9)

  • Pituitary Gland

    a small, unpaired gland situated in the sella turcica. it is connected to the hypothalamus by a short stalk which is called the infundibulum.

  • Grade 2 Hypophysitis, CTCAE|Grade 2 Hypophysitis

    moderate; minimal, local or noninvasive intervention indicated; limiting instrumental adl or mild/moderate impact on age-appropriate normal daily activity (pediatric)

  • Grade 3 Hypophysitis, CTCAE|Grade 3 Hypophysitis

    severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care adl or severe impact on age-appropriate normal daily activity (pediatric)

  • Pituitary Hemorrhage

    bleeding within the pituitary gland.

  • Autoimmune Hypophysitis|Lymphocytic Hypophysitis

    an autoimmune condition affecting the pituitary gland, characterized by lymphocytic infiltration, commonly presenting with pituitary hormone deficiencies.

  • Grade 1 Hypophysitis, CTCAE|Grade 1 Hypophysitis

    asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated

  • Grade 2 Hypophysitis, CTCAE|Grade 2 Hypophysitis

    moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental adl

  • Grade 3 Hypophysitis, CTCAE|Grade 3 Hypophysitis

    severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self care adl

  • Grade 4 Hypophysitis, CTCAE|Grade 4 Hypophysitis

    life-threatening consequences; urgent intervention indicated

  • Grade 5 Hypophysitis, CTCAE|Grade 5 Hypophysitis

    death

  • Hypophysitis

    an inflammatory process in the pituitary gland.

  • Hypophysitis, CTCAE|Hypophysitis

    a disorder characterized by inflammation and cellular infiltration of the pituitary gland.

  • Lymphocytic Neurohypophysitis

    an autoimmune condition affecting the posterior pituitary gland, which is characterized by lymphocytic infiltration, and which often presents as diabetes insipidus.

  • Cerebrospinal Fluid Rhinorrhea

    discharge of cerebrospinal fluid through the nose.

Patient EducationClinical

Pituitary Disorders

Your pituitary gland is a pea-sized gland at the base of your brain. The pituitary is the "master control gland" - it makes hormones that affect growth and the functions of other glands in the body.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E23.6 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
253.8 Pituitary disorder NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E23.6Overview

Is E23.6 (Hypofunction and other disorders of the pituitary gland) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other disorders of pituitary gland on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E23.6 group to?

When other disorders of pituitary gland is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E23.6?

Under the General Equivalence Mappings, other disorders of pituitary gland converts to ICD-9-CM 253.8 (pituitary disorder NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.