2026 ICD-10-CM Diagnosis Code D81.30Adenosine deaminase deficiency, unspecified

ICD-10-CM Codes›D50–D89›D80-D89›D81

ICD-10-CM D81.30
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D81.30 is a billable ICD-10-CM diagnosis code for adenosine deaminase deficiency, unspecified. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026). Coders also document this condition as adenosine deaminase deficiency. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Immunity disorders and Other specified and unspecified nutritional and metabolic disorders.

Code Identity

ICD-10-CM Code
D81.30
Billable Status
Yes — Valid for Submission
Code Describes
Adenosine deaminase deficiency, unspecified
Short Description
Adenosine deaminase deficiency, unspecified
Same as the full description in the CMS dataset.
Parent Code
D81.3
Adenosine deaminase [ADA] deficiency

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD80-D89Certain disorders involving the immune mechanism
CategoryD81Combined immunodeficiencies
This CodeD81.30Adenosine deaminase deficiency, unspecified

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Adenosine deaminase deficiency

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • ADA deficiency NOS

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Deficiency, deficient
      • adenosine deaminase (ADA)
    • Immunodeficiency
      • with
        • adenosine-deaminase deficiency

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD008
Immunity disorders
Default principal diagnosis: inpatient Yes · outpatient Yes
CCSR END016
Other specified and unspecified nutritional and metabolic disorders
Default principal diagnosis: inpatient No · outpatient No

Patient EducationClinical

Adenosine deaminase deficiency

Adenosine deaminase (ADA) deficiency is a disorder that affects the immune system. Specifically, ADA deficiency impairs the development and function of immune cells called lymphocytes. Lymphocytes are white blood cells that help the body fight infections.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Code History & ChangesHistory

Replacement D81.30 replaces the following previously assigned code(s):

  • D81.3 - Adenosine deaminase [ADA] deficiency
FY 2020AddedAdded to the ICD-10-CM code setEffective October 1, 2019.
FY 2021–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D81.30Overview

Is D81.30 (Adenosine deaminase [ADA] deficiency) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report adenosine deaminase deficiency, unspecified on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.