ICD-10-CM Code D81.3

Adenosine deaminase [ADA] deficiency

Version 2020 Replaced Code Non-Billable Code

Not Valid for Submission

D81.3 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of adenosine deaminase [ada] deficiency. The code is NOT valid for the year 2020 for the submission of HIPAA-covered transactions.

ICD-10:D81.3
Short Description:Adenosine deaminase [ADA] deficiency
Long Description:Adenosine deaminase [ADA] deficiency

Consider the following ICD-10 codes with a higher level of specificity:

  • D81.30 - Adenosine deaminase deficiency, unspecified
  • D81.31 - Severe combined immunodeficiency due to adenosine deaminase deficiency
  • D81.32 - Adenosine deaminase 2 deficiency
  • D81.39 - Other adenosine deaminase deficiency

Replaced Code

This code was replaced in the 2020 ICD-10 code set with the code(s) listed below. The National Center for Health Statistics (NCHS) has published an update to the ICD-10-CM diagnosis codes which became effective October 1, 2019. This code was replaced for the FY 2020 (October 1, 2019 - September 30, 2020).

  • D81.30 - Adenosine deaminase deficiency, unspecified
  • D81.31 - Severe combined immunodef due to adenosine deaminase defic
  • D81.32 - Adenosine deaminase 2 deficiency
  • D81.39 - Other adenosine deaminase deficiency

Convert D81.3 to ICD-9

  • 277.2 - Purine/pyrimid dis NEC (Approximate Flag)

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Certain disorders involving the immune mechanism (D80-D89)
      • Combined immunodeficiencies (D81)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - Code Deleted, effective from 10/1/2019 through 9/30/2020

Information for Patients


Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them.

If your immune system cannot do its job, the results can be serious. Disorders of the immune system include

  • Allergy and asthma - immune responses to substances that are usually not harmful
  • Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts
  • Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake

[Learn More]

Adenosine deaminase deficiency Adenosine deaminase (ADA) deficiency is an inherited disorder that damages the immune system and causes severe combined immunodeficiency (SCID). People with SCID lack virtually all immune protection from bacteria, viruses, and fungi. They are prone to repeated and persistent infections that can be very serious or life-threatening. These infections are often caused by "opportunistic" organisms that ordinarily do not cause illness in people with a normal immune system.The main symptoms of ADA deficiency are pneumonia, chronic diarrhea, and widespread skin rashes. Affected children also grow much more slowly than healthy children and some have developmental delay.Most individuals with ADA deficiency are diagnosed with SCID in the first 6 months of life. Without treatment, these babies usually do not survive past age 2. In about 10 percent to 15 percent of cases, onset of immune deficiency is delayed to between 6 and 24 months of age (delayed onset) or even until adulthood (late onset). Immune deficiency in these later-onset cases tends to be less severe, causing primarily recurrent upper respiratory and ear infections. Over time, affected individuals may develop chronic lung damage, malnutrition, and other health problems.
[Learn More]