D81.9 - Combined immunodeficiency, unspecified
| ICD-10: | D81.9 |
| Short Description: | Combined immunodeficiency, unspecified |
| Long Description: | Combined immunodeficiency, unspecified |
| Status: | Valid for Submission |
| Version: | ICD-10-CM 2022 |
| Code Classification: |
D81.9 is a billable ICD-10 code used to specify a medical diagnosis of combined immunodeficiency, unspecified. The code is valid during the fiscal year 2022 from October 01, 2021 through September 30, 2022 for the submission of HIPAA-covered transactions.
This code might also be used to specify conditions or terms like autosomal recessive scid, autosomal recessive severe combined immunodeficiency, benign combined immunodeficiency, combined immunodeficiency disease, combined immunodeficiency with faciooculoskeletal anomalies syndrome , combined immunodeficiency with granulomatosis, etc.
Unspecified diagnosis codes like D81.9 are acceptable when clinical information is unknown or not available about a particular condition. Although a more specific code is preferable, unspecified codes should be used when such codes most accurately reflect what is known about a patient's condition. Specific diagnosis codes should not be used if not supported by the patient's medical record.
Tabular List of Diseases and Injuries
The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more. The following references are applicable to this diagnosis code:
Inclusion Terms
Inclusion TermsThese terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
- Severe combined immunodeficiency disorder SCID NOS
Index to Diseases and Injuries References
The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for this diagnosis code are found in the injuries and diseases index:
- - Agammaglobulinemia (acquired (secondary)) (nonfamilial) - D80.1
- - with
- - lymphopenia - D81.9
- - lymphopenic - D81.9
- - with
- - Immunodeficiency - D84.9
- - combined - D81.9
- - severe (SCID) - D81.9
- - severe combined (SCID) - D81.9
- - combined - D81.9
- - Syndrome - See Also: Disease;
- - combined immunity deficiency - D81.9
- - immunity deficiency, combined - D81.9
- - immunodeficiency
- - combined - D81.9
Approximate Synonyms
The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:
- Autosomal recessive SCID
- Autosomal recessive severe combined immunodeficiency
- Benign combined immunodeficiency
- Combined immunodeficiency disease
- Combined immunodeficiency with faciooculoskeletal anomalies syndrome
- Combined immunodeficiency with granulomatosis
- Hepatic veno-occlusive disease with immunodeficiency syndrome
- Obstruction of visceral vein
- Severe combined immunodeficiency disease
- Severe combined immunodeficiency with low T- and B-cell numbers
- Severe combined immunodeficiency with low T- and B-cell numbers
- Severe combined immunodeficiency with low T- and B-cell numbers
- Severe combined immunodeficiency with maternofetal engraftment
- Severe combined immunodeficiency, microcephaly, growth retardation, sensitivity to ionizing radiation syndrome
- Short-limb skeletal dysplasia with severe combined immunodeficiency
- Veno-occlusive disease of the liver
Clinical Information
- SEVERE COMBINED IMMUNODEFICIENCY-. group of rare congenital disorders characterized by impairment of both humoral and cell mediated immunity leukopenia and low or absent antibody levels. it is inherited as an x linked or autosomal recessive defect. mutations occurring in many different genes cause human severe combined immunodeficiency scid.
- X LINKED COMBINED IMMUNODEFICIENCY DISEASES-. forms of combined immunodeficiency caused by mutations in the gene for interleukin receptor common gamma subunit. both severe and non severe subtypes of the disease have been identified.
Diagnostic Related Groups - MS-DRG Mapping
The is diagnosis code is grouped in the following groups for version MS-DRG V39.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC). applicable from 10/01/2021 through 09/30/2022.
| MS-DRG | MS-DRG Title | MCD | Relative Weight |
|---|---|---|---|
| 808 | MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITH MCC | 16 | 2.1779 |
| 809 | MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITH CC | 16 | 1.2217 |
| 810 | MAJOR HEMATOLOGICAL AND IMMUNOLOGICAL DIAGNOSES EXCEPT SICKLE CELL CRISIS AND COAGULATION DISORDERS WITHOUT CC/MCC | 16 | 0.9607 |
The relative weight of a diagnostic related group determines the reimbursement rate based on the severity of a patient's illness and the associated cost of care during hospitalization.
Convert to ICD-9 Code
The General Equivalency Mapping (GEM) crosswalk indicates an approximate mapping between the ICD-10 code D81.9 its ICD-9 equivalent. The approximate mapping means there is not an exact match between the ICD-10 code and the ICD-9 code and the mapped code is not a precise representation of the original code.
- 279.2 - Combined immunity defic (Approximate Flag)
Patient Education
Immune System and Disorders
What is the immune system?
Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.
When germs such as bacteria or viruses invade your body, they attack and multiply. This is called an infection. The infection causes the disease that makes you sick. Your immune system protects you from the disease by fighting off the germs.
What are the parts of the immune system?
The immune system has many different parts, including
- Your skin, which can help prevent germs from getting into the body
- Mucous membranes, which are the moist, inner linings of some organs and body cavities. They make mucus and other substances which can trap and fight germs.
- White blood cells, which fight germs
- Organs and tissues of the lymph system, such as the thymus, spleen, tonsils, lymph nodes, lymph vessels, and bone marrow. They produce, store, and carry white blood cells.
How does the immune system work?
Your immune system defends your body against substances it sees as harmful or foreign. These substances are called antigens. They may be germs such as bacteria and viruses. They might be chemicals or toxins. They could also be cells that are damaged from things like cancer or sunburn.
When your immune system recognizes an antigen, it attacks it. This is called an immune response. Part of this response is to make antibodies. Antibodies are proteins that work to attack, weaken, and destroy antigens. Your body also makes other cells to fight the antigen.
Afterwards, your immune system remembers the antigen. If it sees the antigen again, it can recognize it. It will quickly send out the right antibodies, so in most cases, you don't get sick. This protection against a certain disease is called immunity.
What are the types of immunity?
There are three different types of immunity:
- Innate immunity is the protection that you are born with. It is your body's first line of defense. It includes barriers such as the skin and mucous membranes. They keep harmful substances from entering the body. It also includes some cells and chemicals which can attack foreign substances.
- Active immunity, also called adaptive immunity, develops when you are infected with or vaccinated against a foreign substance. Active immunity is usually long-lasting. For many diseases, it can last your entire life.
- Passive immunity happens when you receive antibodies to a disease instead of making them through your own immune system. For example, newborn babies have antibodies from their mothers. People can also get passive immunity through blood products that contain antibodies. This kind of immunity gives you protection right away. But it only lasts a few weeks or months.
What can go wrong with the immune system?
Sometimes a person may have an immune response even though there is no real threat. This can lead to problems such as allergies, asthma, and autoimmune diseases. If you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake.
Other immune system problems happen when your immune system does not work correctly. These problems include immunodeficiency diseases. If you have an immunodeficiency disease, you get sick more often. Your infections may last longer and can be more serious and harder to treat. They are often genetic disorders.
There are other diseases that can affect your immune system. For example, HIV is a virus that harms your immune system by destroying your white blood cells. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). People with AIDS have badly damaged immune systems. They get an increasing number of severe illnesses.
[Read More]
Immune System and Disorders
What is the immune system?
Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.
When germs such as bacteria or viruses invade your body, they attack and multiply. This is called an infection. The infection causes the disease that makes you sick. Your immune system protects you from the disease by fighting off the germs.
What are the parts of the immune system?
The immune system has many different parts, including
- Your skin, which can help prevent germs from getting into the body
- Mucous membranes, which are the moist, inner linings of some organs and body cavities. They make mucus and other substances which can trap and fight germs.
- White blood cells, which fight germs
- Organs and tissues of the lymph system, such as the thymus, spleen, tonsils, lymph nodes, lymph vessels, and bone marrow. They produce, store, and carry white blood cells.
How does the immune system work?
Your immune system defends your body against substances it sees as harmful or foreign. These substances are called antigens. They may be germs such as bacteria and viruses. They might be chemicals or toxins. They could also be cells that are damaged from things like cancer or sunburn.
When your immune system recognizes an antigen, it attacks it. This is called an immune response. Part of this response is to make antibodies. Antibodies are proteins that work to attack, weaken, and destroy antigens. Your body also makes other cells to fight the antigen.
Afterwards, your immune system remembers the antigen. If it sees the antigen again, it can recognize it. It will quickly send out the right antibodies, so in most cases, you don't get sick. This protection against a certain disease is called immunity.
What are the types of immunity?
There are three different types of immunity:
- Innate immunity is the protection that you are born with. It is your body's first line of defense. It includes barriers such as the skin and mucous membranes. They keep harmful substances from entering the body. It also includes some cells and chemicals which can attack foreign substances.
- Active immunity, also called adaptive immunity, develops when you are infected with or vaccinated against a foreign substance. Active immunity is usually long-lasting. For many diseases, it can last your entire life.
- Passive immunity happens when you receive antibodies to a disease instead of making them through your own immune system. For example, newborn babies have antibodies from their mothers. People can also get passive immunity through blood products that contain antibodies. This kind of immunity gives you protection right away. But it only lasts a few weeks or months.
What can go wrong with the immune system?
Sometimes a person may have an immune response even though there is no real threat. This can lead to problems such as allergies, asthma, and autoimmune diseases. If you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake.
Other immune system problems happen when your immune system does not work correctly. These problems include immunodeficiency diseases. If you have an immunodeficiency disease, you get sick more often. Your infections may last longer and can be more serious and harder to treat. They are often genetic disorders.
There are other diseases that can affect your immune system. For example, HIV is a virus that harms your immune system by destroying your white blood cells. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). People with AIDS have badly damaged immune systems. They get an increasing number of severe illnesses.
[Learn More in MedlinePlus]
Related Codes Browser
| ICD Code | Description | Valid for Submission |
|---|---|---|
| D81 | Combined immunodeficiencies | NON-BILLABLE CODE |
| D81.0 | Severe combined immunodeficiency [SCID] with reticular dysgenesis | BILLABLE CODE |
| D81.1 | Severe combined immunodeficiency [SCID] with low T- and B-cell numbers | BILLABLE CODE |
| D81.2 | Severe combined immunodeficiency [SCID] with low or normal B-cell numbers | BILLABLE CODE |
| D81.3 | Adenosine deaminase [ADA] deficiency | NON-BILLABLE CODE |
| D81.30 | Adenosine deaminase deficiency, unspecified | BILLABLE CODE |
| D81.31 | Severe combined immunodeficiency due to adenosine deaminase deficiency | BILLABLE CODE |
| D81.32 | Adenosine deaminase 2 deficiency | BILLABLE CODE |
| D81.39 | Other adenosine deaminase deficiency | BILLABLE CODE |
| D81.4 | Nezelof's syndrome | BILLABLE CODE |
| D81.5 | Purine nucleoside phosphorylase [PNP] deficiency | BILLABLE CODE |
| D81.6 | Major histocompatibility complex class I deficiency | BILLABLE CODE |
| D81.7 | Major histocompatibility complex class II deficiency | BILLABLE CODE |
| D81.8 | Other combined immunodeficiencies | NON-BILLABLE CODE |
| D81.81 | Biotin-dependent carboxylase deficiency | NON-BILLABLE CODE |
| D81.810 | Biotinidase deficiency | BILLABLE CODE |
| D81.818 | Other biotin-dependent carboxylase deficiency | BILLABLE CODE |
| D81.819 | Biotin-dependent carboxylase deficiency, unspecified | BILLABLE CODE |
| D81.89 | Other combined immunodeficiencies | BILLABLE CODE |
Code History
- FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
- FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
- FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
- FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
- FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
- FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016 (First year ICD-10-CM implemented into the HIPAA code set)
