Hemolytic anemias (D55-D59) ICD-10-CM
The D55–D59 section covers hemolytic anemias with 96 ICD-10-CM diagnosis codes, of which 79 are billable in fiscal year 2026. The section is organized into the 5 code ranges listed below.
Code Ranges in This Section 5 ranges · 96 codes
| Code Range | Title | Codes | Billable |
|---|---|---|---|
| D55 | Anemia due to enzyme disorders (D55) | 9 | 7 |
| D56 | Thalassemia (D56) | 9 | 8 |
| D57 | Sickle-cell disorders (D57) | 53 | 43 |
| D58 | Other hereditary hemolytic anemias (D58) | 6 | 5 |
| D59 | Acquired hemolytic anemia (D59) | 19 | 16 |
The info icon previews the code ranges inside each row and its instructional notations from the official Tabular List.
About the D55–D59 Code Range
ICD-10 codes D55-D59 classify various types of hemolytic anemias, which are conditions characterized by the destruction of red blood cells. This range includes anemia caused by enzyme deficiencies, inherited disorders like thalassemia, sickle-cell conditions, hereditary membrane defects, and acquired forms of hemolytic anemia.
The codes starting with D55 capture anemias due to enzyme disorders such as glucose-6-phosphate dehydrogenase (G6PD) deficiency, a well-known cause often referred to as favism or G-6-PD variant anemia. Thalassemia syndromes fall under D56, including alpha, beta, delta-beta, and other variants, often linked by synonyms like Hemoglobin H disease and Hemoglobin E-beta thalassemia. The D57 series details sickle-cell disorders, covering sickle-cell anemia with or without crisis and associated complications like acute chest syndrome and splenic sequestration. Codes beginning D58 address hereditary hemolytic anemias such as hereditary spherocytosis and elliptocytosis, conditions caused by defects in red blood cell membranes. Finally, D59 concerns acquired hemolytic anemias, including drug-induced autoimmune types, hemolytic-uremic syndrome, and paroxysmal nocturnal hemoglobinuria. These codes provide precise classifications for hemolytic anemias based on cause and clinical presentation, assisting accurate diagnosis and treatment coding.
Questions About This Page
How many codes are in the D55-D59 range?
The D55-D59 range contains 96 ICD-10-CM diagnosis codes in FY 2026. 79 of them are billable, and the rest are category headers that organize the section.
What conditions does D55-D59 cover?
The range covers hemolytic anemias. The code ranges listed above break it into groups of related conditions, and each one links to its own page with the full code list.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
