Immunodeficiency with predominantly antibody defects (D80) ICD-10-CM
The D80 code range covers immunodeficiency with predominantly antibody defects with 11 ICD-10-CM diagnosis codes. 10 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Codes in the D80 Range 11 codes · 10 billable
- D80 Immunodeficiency with predominantly antibody defectsNon-billable
- D80.0 Hereditary hypogammaglobulinemia
- D80.1 Nonfamilial hypogammaglobulinemia
- D80.2 Selective deficiency of immunoglobulin A [IgA]
- D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
- D80.4 Selective deficiency of immunoglobulin M [IgM]
- D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
- D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
- D80.7 Transient hypogammaglobulinemia of infancy
- D80.8 Other immunodeficiencies with predominantly antibody defects
- D80.9 Immunodeficiency with predominantly antibody defects, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the D80 range.
Transient Hypogammaglobulinemia of Infancy
A rare, primary humoral immunodeficiency of childhood characterized by decreasing serum levels of immunoglobulin G (IgG) as maternal antibodies clear the circulation while serum levels of immunoglobulin A and immunoglobulin M remain normal or are slightly decreased. Diagnosis may be suspected after the age of six months when a child's own synthesis of IgG should accelerate but it must be confirmed retrospectively after normalization of all serum immunoglobulin levels is seen by ages 2-6. This disorder may be caused by inadequate activation of progenitor B cells, defective class-switching or may even represent a maturational variant. Typically, a normal response to protein antigens is found while there is a notably diminished response to viral and bacterial polysaccharide antigens. Clinical presentation may include recurrent infections especially those of the respiratory tract. Despite increased susceptibility to infection in childhood, this disorder is self-limited with minimal implications for a normal life span.
About the D80 Code Range
These immune deficiencies mainly involve antibody defects. The subdivisions describe different patterns of immunoglobulin levels and antibody deficiency.
D80.0, D80.1, and D80.7 distinguish hereditary, nonfamilial, and transient infancy forms. Other subdivisions identify selective deficiencies of IgA, IgG subclasses, or IgM. They also distinguish increased IgM from antibody deficiency with near-normal immunoglobulins or elevated immunoglobulin levels. The remaining subdivisions describe other antibody-predominant immune deficiencies or an unspecified form.
Questions About This Page
How many billable codes are in the D80 range?
Of the 11 codes in this range, 10 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the D80 range classify?
The range classifies immunodeficiency with predominantly antibody defects. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
