Immunodeficiency with predominantly antibody defects (D80) ICD-10-CM
The D80 code range covers immunodeficiency with predominantly antibody defects with 11 ICD-10-CM diagnosis codes. 10 of them are billable and valid for claim submission in fiscal year 2026, and the category headers group them but cannot themselves be billed.
Codes in the D80 Range 11 codes · 10 billable
- D80 Immunodeficiency with predominantly antibody defectsNon-billable
- D80.0 Hereditary hypogammaglobulinemia
- D80.1 Nonfamilial hypogammaglobulinemia
- D80.2 Selective deficiency of immunoglobulin A [IgA]
- D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
- D80.4 Selective deficiency of immunoglobulin M [IgM]
- D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
- D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
- D80.7 Transient hypogammaglobulinemia of infancy
- D80.8 Other immunodeficiencies with predominantly antibody defects
- D80.9 Immunodeficiency with predominantly antibody defects, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the D80 range.
Agammaglobulinemia
An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.
Pulmonary Alveolar Proteinosis
A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.
About the D80 Code Range
ICD-10 code D80 covers immunodeficiency disorders characterized mainly by problems with antibody production. These codes identify specific defects in the immune system's ability to create effective antibodies, which are crucial for fighting infections.
The section includes codes for various conditions such as D80.0, Hereditary hypogammaglobulinemia, which is also called congenital agammaglobulinemia or B-cell immunodeficiency. D80.1, Nonfamilial hypogammaglobulinemia describes antibody deficiencies without a family history. Selective deficiencies of immunoglobulins like IgA, IgG subclasses, and IgM are coded under D80.2, D80.3, and D80.4 respectively, helping coders pinpoint exact antibody shortages. Conditions such as D80.5, Immunodeficiency with increased IgM, refer to syndromes like X-linked hyper-IgM. Other codes specify antibody deficiencies despite normal or elevated immunoglobulin levels (D80.6), transient low immunoglobulins in infancy (D80.7), and unspecified or other antibody-related immunodeficiencies (D80.8 and D80.9). Including synonyms like “selective immunoglobulin A deficiency” or “hyperimmunoglobulin M syndrome” clarifies these disorders. These codes are essential for diagnosing and documenting immune system conditions affecting antibody function.
Questions About This Page
How many billable codes are in the D80 range?
Of the 11 codes in this range, 10 are billable and valid for claim submission from October 1, 2025 through September 30, 2026. Category header codes group them but cannot be reported on claims.
What does the D80 range classify?
The range classifies immunodeficiency with predominantly antibody defects. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
