Immunodeficiency with predominantly antibody defects (D80)
ICD-10 code D80 covers immunodeficiency disorders characterized mainly by problems with antibody production. These codes identify specific defects in the immune system's ability to create effective antibodies, which are crucial for fighting infections.
The section includes codes for various conditions such as D80.0, Hereditary hypogammaglobulinemia, which is also called congenital agammaglobulinemia or B-cell immunodeficiency. D80.1, Nonfamilial hypogammaglobulinemia describes antibody deficiencies without a family history. Selective deficiencies of immunoglobulins like IgA, IgG subclasses, and IgM are coded under D80.2, D80.3, and D80.4 respectively, helping coders pinpoint exact antibody shortages. Conditions such as D80.5, Immunodeficiency with increased IgM, refer to syndromes like X-linked hyper-IgM. Other codes specify antibody deficiencies despite normal or elevated immunoglobulin levels (D80.6), transient low immunoglobulins in infancy (D80.7), and unspecified or other antibody-related immunodeficiencies (D80.8 and D80.9). Including synonyms like “selective immunoglobulin A deficiency” or “hyperimmunoglobulin M syndrome” clarifies these disorders. These codes are essential for diagnosing and documenting immune system conditions affecting antibody function.
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
Certain disorders involving the immune mechanism (D80-D89)
D80 Immunodeficiency with predominantly antibody defects
- D80.0 Hereditary hypogammaglobulinemia
- D80.1 Nonfamilial hypogammaglobulinemia
- D80.2 Selective deficiency of immunoglobulin A [IgA]
- D80.3 Selective deficiency of immunoglobulin G [IgG] subclasses
- D80.4 Selective deficiency of immunoglobulin M [IgM]
- D80.5 Immunodeficiency with increased immunoglobulin M [IgM]
- D80.6 Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
- D80.7 Transient hypogammaglobulinemia of infancy
- D80.8 Other immunodeficiencies with predominantly antibody defects
- D80.9 Immunodeficiency with predominantly antibody defects, unspecified
Immunodeficiency with predominantly antibody defects (D80)
Clinical Terms
The following clinical terms provide additional context, helping users better understand the clinical background and common associations for each diagnosis listed in this section. Including related terms alongside ICD-10-CM codes supports coders, billers, and healthcare professionals in improving accuracy, enhancing documentation, and facilitating research or patient education.
Agammaglobulinemia
An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.
Pulmonary Alveolar Proteinosis
A PULMONARY ALVEOLI-filling disease, characterized by dense phospholipoproteinaceous deposits in the alveoli, cough, and DYSPNEA. This disease is often related to, congenital or acquired, impaired processing of PULMONARY SURFACTANTS by alveolar macrophages, a process dependent on GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR.
