2024 ICD-10-CM Diagnosis Code D81.82

Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]

ICD-10-CM Code:
ICD-10 Code for:
Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Code Navigator:

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
    • Certain disorders involving the immune mechanism
      • Combined immunodeficiencies

D81.82 is a billable diagnosis code used to specify a medical diagnosis of activated phosphoinositide 3-kinase delta syndrome [apds]. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

Clinical Classification

Tabular List of Diseases and Injuries

The following annotation back-references are applicable to this diagnosis code. The Tabular List of Diseases and Injuries is a list of ICD-10-CM codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more.

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • p110d-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency PASLI disease

Code Also

Code Also
A "code also" note instructs that two codes may be required to fully describe a condition, but this note does not provide sequencing direction.
  • , if applicable, any associated manifestations, such as:
  • bronchiectasis J47
  • herpes virus infections B00
  • other acute respiratory tract infections J00 J06 J20 J22
  • other infections A00 B99
  • pneumonia J12 J18

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Replacement Code

D8182 replaces the following previously assigned ICD-10-CM code(s):

  • D81.89 - Other combined immunodeficiencies

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - Code Added, effective from 10/1/2022 through 9/30/2023


[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.