Immunodeficiency associated with other major defects (D82) ICD-10-CM
The D82 code range covers immunodeficiency associated with other major defects with 8 ICD-10-CM diagnosis codes. 7 of them are billable and valid for claim submission in fiscal year 2027, and the category headers group them but cannot themselves be billed.
Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
- ataxia telangiectasia [Louis-Bar] G11.3
Codes in the D82 Range 8 codes · 7 billable
- D82 Immunodeficiency associated with other major defectsNon-billable
- D82.0 Wiskott-Aldrich syndrome
- D82.1 Di George's syndrome
- D82.2 Immunodeficiency with short-limbed stature
- D82.3 Immunodeficiency following hereditary defective response to Epstein-Barr virus
- D82.4 Hyperimmunoglobulin E [IgE] syndrome
- D82.8 Immunodeficiency associated with other specified major defects
- D82.9 Immunodeficiency associated with major defect, unspecified
Clinical Terms in This Code Range
Definitions from the National Library of Medicine for conditions coded in the D82 range.
DiGeorge Syndrome
Congenital syndrome characterized by a wide spectrum of characteristics including the absence of the THYMUS and PARATHYROID GLANDS resulting in T-cell immunodeficiency, HYPOCALCEMIA, defects in the outflow tract of the heart, and craniofacial anomalies.
Wiskott-Aldrich Syndrome
A rare, X-linked immunodeficiency syndrome characterized by ECZEMA; LYMPHOPENIA; and, recurrent pyogenic infection. It is seen exclusively in young boys. Typically, IMMUNOGLOBULIN M levels are low and IMMUNOGLOBULIN A and IMMUNOGLOBULIN E levels are elevated. Lymphoreticular malignancies are common.
About the D82 Code Range
These conditions involve weakened immune defenses together with other major defects.
The subdivisions distinguish Wiskott-Aldrich syndrome (D82.0) and Di George's syndrome (D82.1) from immunodeficiency with short-limbed stature (D82.2). Other codes identify an inherited defective response to Epstein-Barr virus (D82.3) and hyperimmunoglobulin E syndrome (D82.4). The remaining subdivisions distinguish other specified major defects (D82.8) from an unspecified major defect (D82.9).
Questions About This Page
How many billable codes are in the D82 range?
Of the 8 codes in this range, 7 are billable and valid for claim submission from October 1, 2026 through September 30, 2027. Category header codes group them but cannot be reported on claims.
What does the D82 range classify?
The range classifies immunodeficiency associated with other major defects. Each code links to its own reference page with billing status, MS-DRG grouping, coding notes, and clinical information.
Related References
Source: CMS FY 2027 ICD-10-CM Tabular List and order file, effective October 1, 2026 through September 30, 2027.
