2027 ICD-10-CM Diagnosis Code D49.0Neoplasm of unspecified behavior of digestive system

ICD-10-CM Codes›C00–D49›D49›D49

ICD-10-CM D49.0
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

D49.0 is a billable ICD-10-CM diagnosis code for neoplasm of unspecified behavior of digestive system. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 374 through 376. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Neoplasms of unspecified nature or uncertain behavior.

Code Identity

ICD-10-CM Code
D49.0
Billable Status
Yes — Valid for Submission
Code Describes
Neoplasm of unspecified behavior of digestive system
Short Description
Neoplasm of unspecified behavior of digestive system
Same as the full description in the CMS dataset.
Parent Code
Neoplasms of unspecified behavior

Code Classification

ChapterC00–D49Neoplasms
SectionD49Neoplasms of unspecified behavior
CategoryD49Neoplasms of unspecified behavior
This CodeD49.0Neoplasm of unspecified behavior of digestive system

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Ampulla of Vater surgical margin, involved by tumor
  • Anal, deep radial surgical margin involved by tumor
  • Anal, distal surgical margin involved by tumor
  • Anal, proximal surgical margin involved by tumor
  • Appendix with tumor involvement, with perforation not at tumor
  • Colorectal neoplasm
  • Common bile duct surgical margin, involved by tumor
  • Deep
  • Dudley-Klingenstein syndrome
  • Erosion of esophageal tumor into bronchus
  • Erosion of esophageal tumor into trachea
  • Erythrocytosis due to hepatoma
  • Esophageal surgical margin, involved by tumor
  • Functional pancreatic endocrine tumor
  • Functional status of pancreatic endocrine tumor cannot be assessed
  • Functional status of pancreatic endocrine tumor unknown
  • Gastric wall tumor
  • Gastrointestinal anastomotic tumor recurrence
  • Gastrointestinal stromal neoplasm of duodenum
  • Gastrointestinal stromal neoplasm of Meckel diverticulum
  • Gastrointestinal stromal tumor of small intestine
  • High grade glandular intraepithelial neoplasia of appendix
  • High grade glandular intraepithelial neoplasia of duodenum
  • High grade glandular intraepithelial neoplasia of esophagus
  • High grade glandular intraepithelial neoplasia of large intestine
  • High grade glandular intraepithelial neoplasia of small intestine
  • Inappropriate secondary erythrocytosis
  • Intraductal papillary mucinous neoplasm of pancreas
  • Low grade appendiceal mucinous neoplasm of appendix
  • Mass of vallecula of epiglottis
  • Mixed pancreatic endocrine tumor
  • Mucinous cystic neoplasm with high-grade intraepithelial neoplasia of liver
  • Neoplasm of abdominal esophagus
  • Neoplasm of adenoid
  • Neoplasm of alveolar ridge mucosa
  • Neoplasm of ampulla of Vater
  • Neoplasm of anal canal
  • Neoplasm of anterior aspect of epiglottis
  • Neoplasm of anterior floor of mouth
  • Neoplasm of anterior wall of nasopharynx
  • Neoplasm of anus
  • Neoplasm of appendix
  • Neoplasm of ascending colon
  • Neoplasm of base of tongue
  • Neoplasm of biliary tract
  • Neoplasm of body of pancreas
  • Neoplasm of body of stomach
  • Neoplasm of border of tongue
  • Neoplasm of buccal mucosa
  • Neoplasm of buccal sulcus
  • Neoplasm of cardia of stomach
  • Neoplasm of cecum
  • Neoplasm of cervical esophagus
  • Neoplasm of colon
  • Neoplasm of commissure of lip
  • Neoplasm of common bile duct
  • Neoplasm of cystic duct
  • Neoplasm of descending colon
  • Neoplasm of digestive organ
  • Neoplasm of digestive system
  • Neoplasm of digestive tract
  • Neoplasm of dorsal surface of oral part of tongue
  • Neoplasm of dorsal surface of tongue
  • Neoplasm of duodenal submucosa
  • Neoplasm of duodenum
  • Neoplasm of ear, nose, and throat
  • Neoplasm of endocrine pancreas
  • Neoplasm of esophageal submucosa
  • Neoplasm of esophagus
  • Neoplasm of exocrine pancreas
  • Neoplasm of extrahepatic bile ducts
  • Neoplasm of floor of mouth
  • Neoplasm of frenulum linguae
  • Neoplasm of frenulum of lower lip
  • Neoplasm of frenulum of upper lip
  • Neoplasm of frenum of lip
  • Neoplasm of fundus of stomach
  • Neoplasm of gallbladder
  • Neoplasm of gastric submucosa
  • Neoplasm of gastrointestinal submucosa
  • Neoplasm of gastrointestinal tract
  • Neoplasm of gingival mucosa
  • Neoplasm of glossoepiglottic fold
  • Neoplasm of glossopalatine arch
  • Neoplasm of greater curvature of stomach
  • Neoplasm of gum
  • Neoplasm of hard palate
  • Neoplasm of head of pancreas
  • Neoplasm of hepatic flexure of colon
  • Neoplasm of hypopharyngeal aspect of aryepiglottic fold
  • Neoplasm of hypopharyngeal aspect of interarytenoid fold
  • Neoplasm of hypopharynx
  • Neoplasm of ileum
  • Neoplasm of inferior surface of soft palate
  • Neoplasm of inner aspect of lip
  • Neoplasm of inner aspect of lower lip
  • Neoplasm of inner aspect of upper lip
  • Neoplasm of intestinal tract
  • Neoplasm of intrahepatic bile ducts
  • Neoplasm of jejunum
  • Neoplasm of junctional region of epiglottis
  • Neoplasm of junctional zone of tongue
  • Neoplasm of labial sulcus
  • Neoplasm of large intestine
  • Neoplasm of lateral border of tongue
  • Neoplasm of lateral floor of mouth
  • Neoplasm of lateral nasal wall
  • Neoplasm of lateral wall of nasopharynx
  • Neoplasm of lateral wall of oropharynx
  • Neoplasm of lesser curvature of stomach
  • Neoplasm of lingual tonsil
  • Neoplasm of lip
  • Neoplasm of liver
  • Neoplasm of lower gum
  • Neoplasm of lower third of esophagus
  • Neoplasm of major salivary gland
  • Neoplasm of mandibular buccal sulcus
  • Neoplasm of mandibular labial sulcus
  • Neoplasm of maxillary buccal sulcus
  • Neoplasm of maxillary labial sulcus
  • Neoplasm of Meckel's diverticulum
  • Neoplasm of mesentery
  • Neoplasm of middle third of esophagus
  • Neoplasm of minor salivary gland
  • Neoplasm of mouth
  • Neoplasm of muscle of face
  • Neoplasm of muscle of head
  • Neoplasm of muscle of mastication
  • Neoplasm of nasal cavity and nasopharynx
  • Neoplasm of nasopharyngeal surface of soft palate
  • Neoplasm of nasopharynx
  • Neoplasm of omentum
  • Neoplasm of oral cavity
  • Neoplasm of oral cavity and lip and salivary gland
  • Neoplasm of oral part of tongue
  • Neoplasm of palate
  • Neoplasm of pancreas
  • Neoplasm of pancreatic duct
  • Neoplasm of parietal peritoneum
  • Neoplasm of parotid gland
  • Neoplasm of pelvic peritoneum
  • Neoplasm of periadrenal tissue
  • Neoplasm of perirenal tissue
  • Neoplasm of peritoneum
  • Neoplasm of peritoneum and retroperitoneum
  • Neoplasm of pharyngeal recess
  • Neoplasm of pharyngopalatine arch
  • Neoplasm of pharynx
  • Neoplasm of postcricoid region
  • Neoplasm of posterior hypopharyngeal wall
  • Neoplasm of posterior margin of nasal septum and/or choana
  • Neoplasm of posterior wall of nasopharynx
  • Neoplasm of posterior wall of oropharynx
  • Neoplasm of pyloric antrum
  • Neoplasm of pylorus
  • Neoplasm of pyriform sinus
  • Neoplasm of rectosigmoid junction
  • Neoplasm of rectouterine pouch
  • Neoplasm of rectum
  • Neoplasm of retrocecal tissue
  • Neoplasm of retromolar area
  • Neoplasm of retroperitoneum
  • Neoplasm of salivary gland duct
  • Neoplasm of sigmoid colon
  • Neoplasm of small intestine
  • Neoplasm of soft palate
  • Neoplasm of spleen
  • Neoplasm of splenic flexure of colon
  • Neoplasm of stomach
  • Neoplasm of sublingual gland
  • Neoplasm of submandibular gland
  • Neoplasm of submucosa of intestine
  • Neoplasm of superior wall of nasopharynx
  • Neoplasm of tail of pancreas
  • Neoplasm of the mesocolon
  • Neoplasm of thoracic esophagus
  • Neoplasm of tip of tongue
  • Neoplasm of tongue
  • Neoplasm of tonsil
  • Neoplasm of tonsillar fossa
  • Neoplasm of tonsillar pillar
  • Neoplasm of transverse colon
  • Neoplasm of upper gastrointestinal tract structure
  • Neoplasm of upper gum
  • Neoplasm of upper third of esophagus
  • Neoplasm of uvula
  • Neoplasm of vallecula
  • Neoplasm of ventral surface of tongue
  • Neoplasm of vermilion border of lip
  • Neoplasm of vermilion border of lower lip
  • Neoplasm of vermilion border of upper lip
  • Neoplasm of vestibule of mouth
  • Nonsecretory pancreatic endocrine tumor
  • Overlapping neoplasm of oral cavity and lip and salivary gland
  • Papillary mass of biliary tract
  • Peritoneal tumor implant present
  • Tongue benign neoplasm excised
  • Tumor limited to the pancreas
  • Tumor of salivary gland

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to D49.0: its own notes plus those printed at D49 and Chapter 2. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From D49 Neoplasms of unspecified behavior applies to 14 codes
  • 'growth' NOS
  • neoplasm NOS
  • new growth NOS
  • tumor NOS

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

  • neoplasm of unspecified behavior of margin of anus (D49.2)
  • neoplasm of unspecified behavior of perianal skin (D49.2)
  • neoplasm of unspecified behavior of skin of anus (D49.2)

Excludes2

Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.

From D49 Neoplasms of unspecified behavior applies to 14 codes
  • neoplasms of uncertain behavior (D37-D44, D48)

Notes

General instructions on how these codes are used.

From D49 Neoplasms of unspecified behavior applies to 14 codes
  • Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
From Chapter 2 (C00-D49) Neoplasms applies to 1,730 codes
  • Functional activity
  • All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
  • Morphology [Histology]
  • Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
  • Primary malignant neoplasms overlapping site boundaries
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
  • Malignant neoplasm of ectopic tissue
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name D49.0, its category, or a range that includes it.

Excludes1 4

These codes carry an Excludes1 note naming D49.0: they are not reported together with it, unless the two conditions are unrelated.

  • D49.2 Neoplasm of unspecified behavior of bone, soft tissue, and skin
    neoplasm of unspecified behavior of anal canal (D49.0)
  • D49.2 Neoplasm of unspecified behavior of bone, soft tissue, and skin
    neoplasm of unspecified behavior of anus NOS (D49.0)
  • D49.2 Neoplasm of unspecified behavior of bone, soft tissue, and skin
    neoplasm of unspecified behavior of vermilion border of lip (D49.0)
  • Block D37-D48 Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
    neoplasms of unspecified behavior (D49.-) names D49.-, which includes this code

Notes 1

These notes mention D49.0.

  • D49 Neoplasms of unspecified behavior
    Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth. names D49, which includes this code

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR NEO072
Neoplasms of unspecified nature or uncertain behavior
Default principal diagnosis: inpatient Yes · outpatient Yes

Table of NeoplasmsClinical

Anatomical sites in the Table of Neoplasms that reference this code family.

SiteMalig.
Primary
Malig.
Secondary
Ca
in situ
BenignUncertainUnspec.
adenoid (pharynx) (tissue)C11.1C79.89D00.08D10.6D37.05D49.0
alimentary canal or tract NECC26.9C78.80D01.9D13.99D37.9D49.0
alveolarC03.9C79.89D00.03D10.39D37.09D49.0
alveolar › mucosaC03.9C79.89D00.03D10.39D37.09D49.0
alveolar › mucosa › lowerC03.1C79.89D00.03D10.39D37.09D49.0
alveolar › mucosa › upperC03.0C79.89D00.03D10.39D37.09D49.0
alveolar › ridge or process › mucosaC03.9C79.89D00.03D10.39D37.09D49.0
alveolar › ridge or process › mucosa › lowerC03.1C79.89D00.03D10.39D37.09D49.0
alveolar › ridge or process › mucosa › upperC03.0C79.89D00.03D10.39D37.09D49.0
alveolar › sulcusC06.1C79.89D00.02D10.39D37.09D49.0
alveolusC03.9C79.89D00.03D10.39D37.09D49.0
alveolus › lowerC03.1C79.89D00.03D10.39D37.09D49.0
alveolus › upperC03.0C79.89D00.03D10.39D37.09D49.0
ampulla of VaterC24.1C78.89D01.5D13.5D37.6D49.0
anorectum, anorectal (junction)C21.8C78.5D01.3D12.9D37.8D49.0
antrum (Highmore) (maxillary) › pyloricC16.3C78.89D00.2D13.1D37.1D49.0
anus, analC21.0C78.5D01.3D12.9D37.8D49.0
anus, anal › canalC21.1C78.5D01.3D12.9D37.8D49.0
anus, anal › cloacogenic zoneC21.2C78.5D01.3D12.9D37.8D49.0
anus, anal › sphincterC21.1C78.5D01.3D12.9D37.8D49.0
appendixC18.1C78.5D01.0D12.1D37.3D49.0
aryepiglottic foldC13.1C79.89D00.08D10.7D37.05D49.0
aryepiglottic fold › hypopharyngeal aspectC13.1C79.89D00.08D10.7D37.05D49.0
aryepiglottic fold › marginal zoneC13.1C79.89D00.08D10.7D37.05D49.0
auditory › tube › openingC11.2C79.89D00.08D10.6D37.05D49.0
bile or biliary (tract)C24.9C78.89D01.5D13.5D37.6D49.0
bile or biliary (tract) › canaliculi (biliferi) (intrahepatic)C22.1C78.7D01.5D13.4D37.6D49.0
bile or biliary (tract) › canals, interlobularC22.1C78.89D01.5D13.4D37.6D49.0
bile or biliary (tract) › duct or passage (common) (cystic) (extrahepatic)C24.0C78.89D01.5D13.5D37.6D49.0
bile or biliary (tract) › duct or passage (common) (cystic) (extrahepatic) › interlobularC22.1C78.89D01.5D13.4D37.6D49.0
bile or biliary (tract) › duct or passage (common) (cystic) (extrahepatic) › intrahepaticC22.1C78.7D01.5D13.4D37.6D49.0
bile or biliary (tract) › duct or passage (common) (cystic) (extrahepatic) › intrahepatic › and extrahepaticC24.8C78.89D01.5D13.5D37.6D49.0
book-leaf (mouth)C06.89C79.89D00.00D10.39D37.09D49.0
branchial (cleft) (cyst) (vestiges)C10.4C79.89D00.08D10.5D37.05D49.0
buccal (cavity)C06.9C79.89D00.00D10.39D37.09D49.0
buccal (cavity) › commissureC06.0C79.89D00.02D10.39D37.09D49.0
buccal (cavity) › groove (lower) (upper)C06.1C79.89D00.02D10.39D37.09D49.0
buccal (cavity) › mucosaC06.0C79.89D00.02D10.39D37.09D49.0
buccal (cavity) › sulcus (lower) (upper)C06.1C79.89D00.02D10.39D37.09D49.0
canal › analC21.1C78.5D01.3D12.9D37.8D49.0
canaliculi, biliary (biliferi) (intrahepatic)C22.1C78.7D01.5D13.4D37.6D49.0
caput coliC18.0C78.5D01.0D12.0D37.4D49.0
cardia (gastric)C16.0C78.89D00.2D13.1D37.1D49.0
cardiac orifice (stomach)C16.0C78.89D00.2D13.1D37.1D49.0
cardio-esophageal junctionC16.0C78.89D00.2D13.1D37.1D49.0
cardio-esophagusC16.0C78.89D00.2D13.1D37.1D49.0
cartilage (articular) (joint) NEC [See Also: Neoplasm, bone] › epiglottis › anterior surfaceC10.1C79.89D00.08D10.5D37.05D49.0
cavity › buccalC06.9C79.89D00.00D10.30D37.09D49.0
cavity › oralC06.9C79.89D00.00D10.30D37.09D49.0
cavity › peritonealC48.2C78.6–D20.1D48.4D49.0
cecumC18.0C78.5D01.0D12.0D37.4D49.0
cheek › inner aspectC06.0C79.89D00.02D10.39D37.09D49.0
cheek › internalC06.0C79.89D00.02D10.39D37.09D49.0
cheek › mucosaC06.0C79.89D00.02D10.39D37.09D49.0
choanaC11.3C79.89D00.08D10.6D37.05D49.0
cholangioleC22.1C78.89D01.5D13.4D37.6D49.0
choledochal ductC24.0C78.89D01.5D13.5D37.6D49.0
cloacogenic zoneC21.2C78.5D01.3D12.9D37.8D49.0
colon [See Also: Neoplasm, intestine, large] › with rectumC19C78.5D01.1D12.7D37.5D49.0
commissure › labial, lipC00.6C79.89D00.01D10.39D37.01D49.0
common (bile) ductC24.0C78.89D01.5D13.5D37.6D49.0
connective tissue NEC › jawC03.9C79.89D00.03D10.39D48.1D49.0
connective tissue NEC › retroperitoneumC48.0C78.6–D20.0D48.3D49.0
corpus › gastricC16.2C78.89D00.2D13.1D37.1D49.0
cricoidC13.0C79.89D00.08D10.7D37.05D49.0
cricopharynxC13.0C79.89D00.08D10.7D37.05D49.0
crypt of MorgagniC21.8C78.5D01.3D12.9D37.8D49.0
cul-de-sac (Douglas')C48.1C78.6–D20.1D48.4D49.0
cystic (bile) duct (common)C24.0C78.89D01.5D13.5D37.6D49.0
digestive organs, system, tube, or tract NECC26.9C78.89D01.9D13.99D37.9D49.0
Douglas' cul-de-sac or pouchC48.1C78.6–D20.1D48.4D49.0
duodenojejunal junctionC17.8C78.4D01.49D13.39D37.2D49.0
duodenumC17.0C78.4D01.49D13.2D37.2D49.0
epiglottis › anterior aspect or surfaceC10.1C79.89D00.08D10.5D37.05D49.0
epiglottis › free border (margin)C10.1C79.89D00.08D10.5D37.05D49.0
epiglottis › junctional regionC10.8C79.89D00.08D10.5D37.05D49.0
esophagogastric junctionC16.0C78.89D00.2D13.1D37.1D49.0
esophagusC15.9C78.89D00.1D13.0D37.8D49.0
esophagus › abdominalC15.5C78.89D00.1D13.0D37.8D49.0
esophagus › cervicalC15.3C78.89D00.1D13.0D37.8D49.0
esophagus › distal (third)C15.5C78.89D00.1D13.0D37.8D49.0
esophagus › lower (third)C15.5C78.89D00.1D13.0D37.8D49.0
esophagus › middle (third)C15.4C78.89D00.1D13.0D37.8D49.0
esophagus › proximal (third)C15.3C78.89D00.1D13.0D37.8D49.0
esophagus › thoracicC15.4C78.89D00.1D13.0D37.8D49.0
esophagus › upper (third)C15.3C78.89D00.1D13.0D37.8D49.0
extrahepatic (bile) ductC24.0C78.89D01.5D13.5D37.6D49.0
fauces, faucial NECC10.9C79.89D00.08D10.5D37.05D49.0
fauces, faucial NEC › pillarsC09.1C79.89D00.08D10.5D37.05D49.0
fauces, faucial NEC › tonsilC09.9C79.89D00.08D10.4D37.05D49.0
fornix › pharyngealC11.3C79.89D00.08D10.6D37.05D49.0
fossa (of) › piriformC12C79.89D00.08D10.7D37.05D49.0
fossa (of) › pyriformC12C79.89D00.08D10.7D37.05D49.0
fossa (of) › RosenmullerC11.2C79.89D00.08D10.6D37.05D49.0
fossa (of) › tonsillarC09.0C79.89D00.08D10.5D37.05D49.0
frenulum › linguaeC02.2C79.89D00.07D10.1D37.02D49.0
fundus › stomachC16.1C78.89D00.2D13.1D37.1D49.0
gall duct (extrahepatic)C24.0C78.89D01.5D13.5D37.6D49.0
gall duct (extrahepatic) › intrahepaticC22.1C78.7D01.5D13.4D37.6D49.0
gallbladderC23C78.89D01.5D13.5D37.6D49.0
gastrocolicC26.9C78.89D01.9D13.99D37.9D49.0
gastroesophageal junctionC16.0C78.89D00.2D13.1D37.1D49.0
gastrointestinal (tract) NECC26.9C78.89D01.9D13.99D37.9D49.0
gingiva (alveolar) (marginal)C03.9C79.89D00.03D10.39D37.09D49.0
gingiva (alveolar) (marginal) › lowerC03.1C79.89D00.03D10.39D37.09D49.0
gingiva (alveolar) (marginal) › mandibularC03.1C79.89D00.03D10.39D37.09D49.0
gingiva (alveolar) (marginal) › maxillaryC03.0C79.89D00.03D10.39D37.09D49.0
gingiva (alveolar) (marginal) › upperC03.0C79.89D00.03D10.39D37.09D49.0
glosso-epiglottic fold (s)C10.1C79.89D00.08D10.5D37.05D49.0
glossopalatine foldC09.1C79.89D00.08D10.5D37.05D49.0
glossopharyngeal sulcusC09.0C79.89D00.08D10.5D37.05D49.0
gumC03.9C79.89D00.03D10.39D37.09D49.0
gum › lowerC03.1C79.89D00.03D10.39D37.09D49.0
gum › upperC03.0C79.89D00.03D10.39D37.09D49.0
hemorrhoidal zoneC21.1C78.5D01.3D12.9D37.8D49.0
hepatic [See Also: Index to disease, by histology]C22.9C78.7D01.5D13.4D37.6D49.0
hepatic [See Also: Index to disease, by histology] › duct (bile)C24.0C78.89D01.5D13.5D37.6D49.0
hepatic [See Also: Index to disease, by histology] › flexure (colon)C18.3C78.5D01.0D12.3D37.4D49.0
hepatic [See Also: Index to disease, by histology] › primaryC22.8C78.7D01.5D13.4D37.6D49.0
hepatobiliaryC24.9C78.89D01.5D13.5D37.6D49.0
hepatoblastomaC22.2C78.7D01.5D13.4D37.6D49.0
hepatomaC22.0C78.7D01.5D13.4D37.6D49.0
hypopharynx, hypopharyngeal NECC13.9C79.89D00.08D10.7D37.05D49.0
hypopharynx, hypopharyngeal NEC › postcricoid regionC13.0C79.89D00.08D10.7D37.05D49.0
hypopharynx, hypopharyngeal NEC › posterior wallC13.2C79.89D00.08D10.7D37.05D49.0
hypopharynx, hypopharyngeal NEC › pyriform fossa (sinus)C12C79.89D00.08D10.7D37.05D49.0
ileocecum, ileocecal (coil) (junction) (valve)C18.0C78.5D01.0D12.0D37.4D49.0
ileumC17.2C78.4D01.49D13.39D37.2D49.0
insular tissue (pancreas)C25.4C78.89D01.7D13.7D37.8D49.0
interarytenoid foldC13.1C79.89D00.08D10.7D37.05D49.0
interarytenoid fold › hypopharyngeal aspectC13.1C79.89D00.08D10.7D37.05D49.0
interarytenoid fold › marginal zoneC13.1C79.89D00.08D10.7D37.05D49.0
interdental papillaeC03.9C79.89D00.03D10.39D37.09D49.0
interdental papillae › lowerC03.1C79.89D00.03D10.39D37.09D49.0
interdental papillae › upperC03.0C79.89D00.03D10.39D37.09D49.0
intestine, intestinalC26.0C78.80D01.40D13.99D37.8D49.0
intestine, intestinal › largeC18.9C78.5D01.0D12.6D37.4D49.0
intestine, intestinal › large › appendixC18.1C78.5D01.0D12.1D37.3D49.0
intestine, intestinal › large › caput coliC18.0C78.5D01.0D12.0D37.4D49.0
intestine, intestinal › large › cecumC18.0C78.5D01.0D12.0D37.4D49.0
intestine, intestinal › large › colonC18.9C78.5D01.0D12.6D37.4D49.0
intestine, intestinal › large › colon › and rectumC19C78.5D01.1D12.7D37.5D49.0
intestine, intestinal › large › colon › ascendingC18.2C78.5D01.0D12.2D37.4D49.0
intestine, intestinal › large › colon › caputC18.0C78.5D01.0D12.0D37.4D49.0
intestine, intestinal › large › colon › descendingC18.6C78.5D01.0D12.4D37.4D49.0
intestine, intestinal › large › colon › distalC18.6C78.5D01.0D12.4D37.4D49.0
intestine, intestinal › large › colon › leftC18.6C78.5D01.0D12.4D37.4D49.0
intestine, intestinal › large › colon › pelvicC18.7C78.5D01.0D12.5D37.4D49.0
intestine, intestinal › large › colon › rightC18.2C78.5D01.0D12.2D37.4D49.0
intestine, intestinal › large › colon › sigmoid (flexure)C18.7C78.5D01.0D12.5D37.4D49.0
intestine, intestinal › large › colon › transverseC18.4C78.5D01.0D12.3D37.4D49.0
intestine, intestinal › large › hepatic flexureC18.3C78.5D01.0D12.3D37.4D49.0
intestine, intestinal › large › ileocecum, ileocecal (coil) (valve)C18.0C78.5D01.0D12.0D37.4D49.0
intestine, intestinal › large › sigmoid flexure (lower) (upper)C18.7C78.5D01.0D12.5D37.4D49.0
intestine, intestinal › large › splenic flexureC18.5C78.5D01.0D12.3D37.4D49.0
intestine, intestinal › smallC17.9C78.4D01.40D13.30D37.2D49.0
intestine, intestinal › small › duodenumC17.0C78.4D01.49D13.2D37.2D49.0
intestine, intestinal › small › ileumC17.2C78.4D01.49D13.39D37.2D49.0
intestine, intestinal › small › jejunumC17.1C78.4D01.49D13.39D37.2D49.0
intestine, intestinal › tract NECC26.0C78.89D01.40D13.99D37.8D49.0
intrahepatic (bile) ductC22.1C78.7D01.5D13.4D37.6D49.0
islands or islets of LangerhansC25.4C78.89D01.7D13.7D37.8D49.0
jaw › soft tissuesC03.9C79.89D00.03D10.39D37.09D49.0
jaw › soft tissues › lowerC03.1C79.89D00.03D10.39D37.09D49.0
jaw › soft tissues › upperC03.0C79.89D00.03D10.39D37.09D49.0
jejunumC17.1C78.4D01.49D13.39D37.2D49.0
junction › anorectalC21.8C78.5D01.3D12.9D37.8D49.0
junction › cardioesophagealC16.0C78.89D00.2D13.1D37.1D49.0
junction › esophagogastricC16.0C78.89D00.2D13.1D37.1D49.0
junction › gastroesophagealC16.0C78.89D00.2D13.1D37.1D49.0
junction › hard and soft palateC05.9C79.89D00.00D10.39D37.09D49.0
junction › ileocecalC18.0C78.5D01.0D12.0D37.4D49.0
junction › pelvirectalC19C78.5D01.1D12.7D37.5D49.0
junction › rectosigmoidC19C78.5D01.1D12.7D37.5D49.0
labial [See Also: Neoplasm, lip]C00.9C79.89D00.01D10.0D37.01D49.0
labial [See Also: Neoplasm, lip] › sulcus (lower) (upper)C06.1C79.89D00.02D10.39D37.09D49.0
Langerhans, islands or isletsC25.4C78.89D01.7D13.7D37.8D49.0
laryngopharynxC13.9C79.89D00.08D10.7D37.05D49.0
larynx, laryngeal NEC › extrinsic NEC › meaning hypopharynxC13.9C79.89D00.08D10.7D37.05D49.0
lingual NEC [See Also: Neoplasm, tongue]C02.9C79.89D00.07D10.1D37.02D49.0
lipC00.9C79.89D00.01D10.0D37.01D49.0
lip › commissureC00.6C79.89D00.01D10.0D37.01D49.0
lip › externalC00.2C79.89D00.01D10.0D37.01D49.0
lip › external › lowerC00.1C79.89D00.01D10.0D37.01D49.0
lip › external › upperC00.0C79.89D00.01D10.0D37.01D49.0
lip › internalC00.5C79.89D00.01D10.0D37.01D49.0
lip › internal › lowerC00.4C79.89D00.01D10.0D37.01D49.0
lip › internal › upperC00.3C79.89D00.01D10.0D37.01D49.0
lip › lipstick areaC00.2C79.89D00.01D10.0D37.01D49.0
lip › lipstick area › lowerC00.1C79.89D00.01D10.0D37.01D49.0
lip › lipstick area › upperC00.0C79.89D00.01D10.0D37.01D49.0
lip › lowerC00.1C79.89D00.01D10.0D37.01D49.0
lip › lower › internalC00.4C79.89D00.01D10.0D37.01D49.0
lip › upperC00.0C79.89D00.01D10.0D37.01D49.0
lip › upper › internalC00.3C79.89D00.01D10.0D37.01D49.0
lip › vermilion borderC00.2C79.89D00.01D10.0D37.01D49.0
lip › vermilion border › lowerC00.1C79.89D00.01D10.0D37.01D49.0
lip › vermilion border › upperC00.0C79.89D00.01D10.0D37.01D49.0
liver [See Also: Index to disease, by histology]C22.9C78.7D01.5D13.4D37.6D49.0
liver [See Also: Index to disease, by histology] › primaryC22.8C78.7D01.5D13.4D37.6D49.0
mandible › alveolar › mucosa (carcinoma)C03.1C79.89D00.03D10.39D37.09D49.0
maxilla, maxillary (superior) › alveolar › mucosaC03.0C79.89D00.03D10.39D37.09D49.0
Meckel diverticulum, malignantC17.3C78.4D01.49D13.39D37.2D49.0
mesentery, mesentericC48.1C78.6–D20.1D48.4D49.0
mesoappendixC48.1C78.6–D20.1D48.4D49.0
mesocolonC48.1C78.6–D20.1D48.4D49.0
mouthC06.9C79.89D00.00D10.30D37.09D49.0
mouth › floorC04.9C79.89D00.06D10.2D37.09D49.0
mouth › floor › anterior portionC04.0C79.89D00.06D10.2D37.09D49.0
mouth › floor › lateral portionC04.1C79.89D00.06D10.2D37.09D49.0
mouth › roofC05.9C79.89D00.00D10.39D37.09D49.0
mouth › specified part NECC06.89C79.89D00.00D10.39D37.09D49.0
mouth › vestibuleC06.1C79.89D00.00D10.39D37.09D49.0
mucosa › alveolar (ridge or process)C03.9C79.89D00.03D10.39D37.09D49.0
mucosa › alveolar (ridge or process) › lowerC03.1C79.89D00.03D10.39D37.09D49.0
mucosa › alveolar (ridge or process) › upperC03.0C79.89D00.03D10.39D37.09D49.0
mucosa › buccalC06.0C79.89D00.02D10.39D37.09D49.0
mucosa › cheekC06.0C79.89D00.02D10.39D37.09D49.0
mucosa › oralC06.0C79.89D00.02D10.39D37.09D49.0
nasopharynx, nasopharyngealC11.9C79.89D00.08D10.6D37.05D49.0
nasopharynx, nasopharyngeal › floorC11.3C79.89D00.08D10.6D37.05D49.0
nasopharynx, nasopharyngeal › roofC11.0C79.89D00.08D10.6D37.05D49.0
nasopharynx, nasopharyngeal › wallC11.9C79.89D00.08D10.6D37.05D49.0
nasopharynx, nasopharyngeal › wall › anteriorC11.3C79.89D00.08D10.6D37.05D49.0
nasopharynx, nasopharyngeal › wall › lateralC11.2C79.89D00.08D10.6D37.05D49.0
nasopharynx, nasopharyngeal › wall › posteriorC11.1C79.89D00.08D10.6D37.05D49.0
nasopharynx, nasopharyngeal › wall › superiorC11.0C79.89D00.08D10.6D37.05D49.0
nose, nasal › choanaC11.3C79.89D00.08D10.6D37.05D49.0
nose, nasal › septum › posterior marginC11.3C79.89D00.08D10.6D37.05D49.0
omentumC48.1C78.6–D20.1D48.4D49.0
oral (cavity)C06.9C79.83D00.00D10.30D37.09D49.0
oral (cavity) › ill-definedC14.8C79.83D00.00D10.30D37.09D49.0
oral (cavity) › mucosaC06.0C79.83D00.02D10.39D37.09D49.0
oropharynxC10.9C79.89D00.08D10.5D37.05D49.0
oropharynx › branchial cleft (vestige)C10.4C79.89D00.08D10.5D37.05D49.0
oropharynx › junctional regionC10.8C79.89D00.08D10.5D37.05D49.0
oropharynx › lateral wallC10.2C79.89D00.08D10.5D37.05D49.0
oropharynx › pillars or faucesC09.1C79.89D00.08D10.5D37.05D49.0
oropharynx › posterior wallC10.3C79.89D00.08D10.5D37.05D49.0
oropharynx › valleculaC10.0C79.89D00.08D10.5D37.05D49.0
palateC05.9C79.89D00.00D10.39D37.09D49.0
palate › hardC05.0C79.89D00.05D10.39D37.09D49.0
palate › junction of hard and soft palateC05.9C79.89D00.00D10.39D37.09D49.0
palate › softC05.1C79.89D00.04D10.39D37.09D49.0
palate › soft › nasopharyngeal surfaceC11.3C79.89D00.08D10.6D37.05D49.0
palate › soft › posterior surfaceC11.3C79.89D00.08D10.6D37.05D49.0
palate › soft › superior surfaceC11.3C79.89D00.08D10.6D37.05D49.0
palatoglossal archC09.1C79.89D00.00D10.5D37.09D49.0
palatopharyngeal archC09.1C79.89D00.00D10.5D37.09D49.0
pancreasC25.9C78.89D01.7D13.6D37.8D49.0
pancreas › bodyC25.1C78.89D01.7D13.6D37.8D49.0
pancreas › duct (of Santorini) (of Wirsung)C25.3C78.89D01.7D13.6D37.8D49.0
pancreas › ectopic tissueC25.7C78.89–D13.6D37.8D49.0
pancreas › headC25.0C78.89D01.7D13.6D37.8D49.0
pancreas › islet cellsC25.4C78.89D01.7D13.7D37.8D49.0
pancreas › neckC25.7C78.89D01.7D13.6D37.8D49.0
pancreas › tailC25.2C78.89D01.7D13.6D37.8D49.0
paranephricC48.0C78.6–D20.0D48.3D49.0
parotid (duct) (gland)C07C79.89D00.00D11.0D37.030D49.0
pelvirectal junctionC19C78.5D01.1D12.7D37.5D49.0
periadrenal (tissue)C48.0C78.6–D20.0D48.3D49.0
perinephricC48.0C78.6–D20.0D48.3D49.0
periodontal tissue NECC03.9C79.89D00.03D10.39D37.09D49.0
peripancreaticC48.0C78.6–D20.0D48.3D49.0
perirenal (tissue)C48.0C78.6–D20.0D48.3D49.0
peritoneum, peritoneal (cavity)C48.2C78.6–D20.1D48.4D49.0
peritoneum, peritoneal (cavity) › parietalC48.1C78.6–D20.1D48.4D49.0
peritoneum, peritoneal (cavity) › pelvicC48.1C78.6–D20.1D48.4D49.0
peritoneum, peritoneal (cavity) › specified part NECC48.1C78.6–D20.1D48.4D49.0
pharynx, pharyngealC14.0C78.32D00.08D10.9D37.05D49.0
pharynx, pharyngeal › bursaC11.1C79.89D00.08D10.6D37.05D49.0
pharynx, pharyngeal › fornixC11.3C79.89D00.08D10.6D37.05D49.0
pharynx, pharyngeal › recessC11.2C79.89D00.08D10.6D37.05D49.0
pharynx, pharyngeal › regionC14.0C79.89D00.08D10.9D37.05D49.0
pharynx, pharyngeal › tonsilC11.1C79.89D00.08D10.6D37.05D49.0
pharynx, pharyngeal › wall (lateral) (posterior)C14.0C79.89D00.08D10.9D37.05D49.0
pillars of faucesC09.1C79.89D00.08D10.5D37.05D49.0
piriform fossa or sinusC12C79.89D00.08D10.7D37.05D49.0
postcricoid (region)C13.0C79.89D00.08D10.7D37.05D49.0
postnasal spaceC11.9C79.89D00.08D10.6D37.05D49.0
prepylorusC16.4C78.89D00.2D13.1D37.1D49.0
pyloric › antrumC16.3C78.89D00.2D13.1D37.1D49.0
pyloric › canalC16.4C78.89D00.2D13.1D37.1D49.0
pylorusC16.4C78.89D00.2D13.1D37.1D49.0
pyriform fossa or sinusC12C79.89D00.08D10.7D37.05D49.0
rectosigmoid (junction)C19C78.5D01.1D12.7D37.5D49.0
rectouterine pouchC48.1C78.6–D20.1D48.4D49.0
rectum (ampulla)C20C78.5D01.2D12.8D37.5D49.0
rectum (ampulla) › and colonC19C78.5D01.1D12.7D37.5D49.0
retrocecalC48.0C78.6–D20.0D48.3D49.0
retromolar (area) (triangle) (trigone)C06.2C79.89D00.00D10.39D37.09D49.0
retroperitoneal (space) (tissue)C48.0C78.6–D20.0D48.3D49.0
retroperitoneumC48.0C78.6–D20.0D48.3D49.0
retropharyngealC14.0C79.89D00.08D10.9D37.05D49.0
Rosenmuller's fossaC11.2C79.89D00.08D10.6D37.05D49.0
salivary gland or duct (major)C08.9C79.89D00.00D11.9D37.039D49.0
salivary gland or duct (major) › minor NECC06.9C79.89D00.00D10.39D37.04D49.0
salivary gland or duct (major) › parotidC07C79.89D00.00D11.0D37.030D49.0
salivary gland or duct (major) › pluriglandularC08.9C79.89D00.00D11.9D37.039D49.0
salivary gland or duct (major) › sublingualC08.1C79.89D00.00D11.7D37.031D49.0
salivary gland or duct (major) › submandibularC08.0C79.89D00.00D11.7D37.032D49.0
salivary gland or duct (major) › submaxillaryC08.0C79.89D00.00D11.7D37.032D49.0
Santorini's ductC25.3C78.89D01.7D13.6D37.8D49.0
septum › nasal › posterior marginC11.3C79.89D00.08D10.6D37.05D49.0
sigmoid flexure (lower) (upper)C18.7C78.5D01.0D12.5D37.4D49.0
sinus (accessory) › pyriformC12C79.89D00.08D10.7D37.05D49.0
sphincter › analC21.1C78.5D01.3D12.9D37.8D49.0
sphincter › of OddiC24.0C78.89D01.5D13.5D37.6D49.0
spleen, splenic NECC26.1C78.89D01.7D13.99D37.8D49.0
spleen, splenic NEC › flexure (colon)C18.5C78.5D01.0D12.3D37.4D49.0
Stensen's ductC07C79.89D00.00D11.0D37.030D49.0
stomachC16.9C78.89D00.2D13.1D37.1D49.0
stomach › antrum (pyloric)C16.3C78.89D00.2D13.1D37.1D49.0
stomach › bodyC16.2C78.89D00.2D13.1D37.1D49.0
stomach › cardiaC16.0C78.89D00.2D13.1D37.1D49.0
stomach › cardiac orificeC16.0C78.89D00.2D13.1D37.1D49.0
stomach › corpusC16.2C78.89D00.2D13.1D37.1D49.0
stomach › fundusC16.1C78.89D00.2D13.1D37.1D49.0
stomach › greater curvature NECC16.6C78.89D00.2D13.1D37.1D49.0
stomach › lesser curvature NECC16.5C78.89D00.2D13.1D37.1D49.0
stomach › prepylorusC16.4C78.89D00.2D13.1D37.1D49.0
stomach › pylorusC16.4C78.89D00.2D13.1D37.1D49.0
stomach › wall NECC16.9C78.89D00.2D13.1D37.1D49.0
stomach › wall NEC › anterior NECC16.8C78.89D00.2D13.1D37.1D49.0
stomach › wall NEC › posterior NECC16.8C78.89D00.2D13.1D37.1D49.0
sublingualC04.9C79.89D00.06D10.2D37.09D49.0
sublingual › gland or ductC08.1C79.89D00.00D11.7D37.031D49.0
submandibular glandC08.0C79.89D00.00D11.7D37.032D49.0
submaxillary gland or ductC08.0C79.89D00.00D11.7D37.032D49.0
throatC14.0C79.89D00.08D10.9D37.05D49.0
tongueC02.9C79.89D00.07D10.1D37.02D49.0
tongue › anterior (two-thirds) NECC02.3C79.89D00.07D10.1D37.02D49.0
tongue › anterior (two-thirds) NEC › dorsal surfaceC02.0C79.89D00.07D10.1D37.02D49.0
tongue › anterior (two-thirds) NEC › ventral surfaceC02.2C79.89D00.07D10.1D37.02D49.0
tongue › base (dorsal surface)C01C79.89D00.07D10.1D37.02D49.0
tongue › border (lateral)C02.1C79.89D00.07D10.1D37.02D49.0
tongue › dorsal surface NECC02.0C79.89D00.07D10.1D37.02D49.0
tongue › fixed part NECC01C79.89D00.07D10.1D37.02D49.0
tongue › foreamen cecumC02.0C79.89D00.07D10.1D37.02D49.0
tongue › frenulum linguaeC02.2C79.89D00.07D10.1D37.02D49.0
tongue › junctional zoneC02.8C79.89D00.07D10.1D37.02D49.0
tongue › margin (lateral)C02.1C79.89D00.07D10.1D37.02D49.0
tongue › midline NECC02.0C79.89D00.07D10.1D37.02D49.0
tongue › mobile part NECC02.3C79.89D00.07D10.1D37.02D49.0
tongue › posterior (third)C01C79.89D00.07D10.1D37.02D49.0
tongue › rootC01C79.89D00.07D10.1D37.02D49.0
tongue › surface (dorsal)C02.0C79.89D00.07D10.1D37.02D49.0
tongue › surface (dorsal) › baseC01C79.89D00.07D10.1D37.02D49.0
tongue › surface (dorsal) › ventralC02.2C79.89D00.07D10.1D37.02D49.0
tongue › tipC02.1C79.89D00.07D10.1D37.02D49.0
tongue › tonsilC02.4C79.89D00.07D10.1D37.02D49.0
tonsilC09.9C79.89D00.08D10.4D37.05D49.0
tonsil › fauces, faucialC09.9C79.89D00.08D10.4D37.05D49.0
tonsil › lingualC02.4C79.89D00.07D10.1D37.02D49.0
tonsil › palatineC09.9C79.89D00.08D10.4D37.05D49.0
tonsil › pharyngealC11.1C79.89D00.08D10.6D37.05D49.0
tonsil › pillar (anterior) (posterior)C09.1C79.89D00.08D10.5D37.05D49.0
tonsillar fossaC09.0C79.89D00.08D10.5D37.05D49.0
tooth socket NECC03.9C79.89D00.03D10.39D37.09D49.0
uvulaC05.2C79.89D00.04D10.39D37.09D49.0
vallecula (epigiottis)C10.0C79.89D00.08D10.5D37.05D49.0
Vater's ampullaC24.1C78.89D01.5D13.5D37.6D49.0
vestibule › mouthC06.1C79.89D00.00D10.39D37.09D49.0
Waldeyer's ringC14.2C79.89D00.08D10.9D37.05D49.0
Wharton's ductC08.0C79.89D00.00D11.7D37.032D49.0
Wirsung's ductC25.3C78.89D01.7D13.6D37.8D49.0

Patient EducationClinical

Digestive Diseases

When you eat, your body breaks food down to a form it can use to build and nourish cells and provide energy. This process is called digestion.

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Convert D49.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
239.0 Digestive neoplasm NOS
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About D49.0Overview

What is the ICD-10 code for neoplasm of unspecified behavior of digestive system?

The ICD-10-CM code for neoplasm of unspecified behavior of digestive system is D49.0 (sometimes written as D490). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is D49.0 (Neoplasms of unspecified behavior) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report neoplasm of unspecified behavior of digestive system on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does D49.0 group to?

When neoplasm of unspecified behavior of digestive system is the principal diagnosis on an inpatient stay, it groups to MS-DRG 375, 374, 376, with relative weights from 0.8925 to 2.1101 depending on complications. Higher weights mean higher Medicare reimbursement.

Can D49.0 be reported with D49.2?

Not as a rule. The Excludes1 note on D49.0 lists "neoplasm of unspecified behavior of margin of anus (D49.2)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of D49.0?

Under the General Equivalence Mappings, neoplasm of unspecified behavior of digestive system converts to ICD-9-CM 239.0 (digestive neoplasm NOS). The mapping is a direct match.