MS-DRG · FY 2026 v43.0
MS-DRG 375 – Digestive Malignancy with CC
A Medical DRG in MDC 06 (Diseases & Disorders of the Digestive System). Inpatient cases group to DRG 375 when the ICD-10-CM principal diagnosis is one of the 93 codes listed below and a secondary diagnosis on the complication or comorbidity (CC) list is present. Its FY 2026 relative weight is 1.2096 with a geometric mean length of stay of 3.5 days.
Medical DRG – assigned by principal diagnosis✓ Official CMS v43.0 dataset
1.2096
Relative Weight
3.5
Geometric Mean LOS (days)
4.5
Arithmetic Mean LOS (days)
93
Principal Diagnosis Codes
Severity family
DRG 374with MCCWeight 2.1387 · GMLOS 5.5 daysDRG 375with CCWeight 1.2096 · GMLOS 3.5 daysDRG 376without CC/MCCWeight 0.9243 · GMLOS 2.3 days
How a case is assigned to DRG 375
The grouper first assigns the case to MDC 06 from the principal diagnosis and finds no qualifying operating-room procedure (this is a Medical DRG; ICD-10-PCS codes do not drive assignment here), then applies the severity split from secondary diagnoses: with MCC → 374; with CC → 375; without CC/MCC → 376.
ICD-10-CM
Principal Diagnosis Codes 93 codes · 21 categories
93 of 93 shown
C15 Malignant neoplasm of esophagus5 codes
C16 Malignant neoplasm of stomach9 codes
- C16.0 Malignant neoplasm of cardia
- C16.1 Malignant neoplasm of fundus of stomach
- C16.2 Malignant neoplasm of body of stomach
- C16.3 Malignant neoplasm of pyloric antrum
- C16.4 Malignant neoplasm of pylorus
- C16.5 Malignant neoplasm of lesser curvature of stomach, unspecified
- C16.6 Malignant neoplasm of greater curvature of stomach, unspecified
- C16.8 Malignant neoplasm of overlapping sites of stomach
- C16.9 Malignant neoplasm of stomach, unspecified
C17 Malignant neoplasm of small intestine6 codes
C18 Malignant neoplasm of colon10 codes
- C18.0 Malignant neoplasm of cecum
- C18.1 Malignant neoplasm of appendix
- C18.2 Malignant neoplasm of ascending colon
- C18.3 Malignant neoplasm of hepatic flexure
- C18.4 Malignant neoplasm of transverse colon
- C18.5 Malignant neoplasm of splenic flexure
- C18.6 Malignant neoplasm of descending colon
- C18.7 Malignant neoplasm of sigmoid colon
- C18.8 Malignant neoplasm of overlapping sites of colon
- C18.9 Malignant neoplasm of colon, unspecified
C19 Malignant neoplasm of rectosigmoid junction1 code
- C19 Malignant neoplasm of rectosigmoid junction
C20 Malignant neoplasm of rectum1 code
- C20 Malignant neoplasm of rectum
C21 Malignant neoplasm of anus and anal canal4 codes
C26 Malignant neoplasm of other and ill-defined digestive organs2 codes
C45 Mesothelioma1 code
- C45.1 Mesothelioma of peritoneum
C46 Kaposi's sarcoma1 code
- C46.4 Kaposi's sarcoma of gastrointestinal sites
C48 Malignant neoplasm of retroperitoneum and peritoneum3 codes
C49 Malignant neoplasm of other connective and soft tissue7 codes
- C49.A0 Gastrointestinal stromal tumor, unspecified site
- C49.A1 Gastrointestinal stromal tumor of esophagus
- C49.A2 Gastrointestinal stromal tumor of stomach
- C49.A3 Gastrointestinal stromal tumor of small intestine
- C49.A4 Gastrointestinal stromal tumor of large intestine
- C49.A5 Gastrointestinal stromal tumor of rectum
- C49.A9 Gastrointestinal stromal tumor of other sites
C76 Malignant neoplasm of other and ill-defined sites1 code
- C76.2 Malignant neoplasm of abdomen
C78 Secondary malignant neoplasm of respiratory and digestive organs5 codes
- C78.4 Secondary malignant neoplasm of small intestine
- C78.5 Secondary malignant neoplasm of large intestine and rectum
- C78.6 Secondary malignant neoplasm of retroperitoneum and peritoneum
- C78.80 Secondary malignant neoplasm of unspecified digestive organ
- C78.89 Secondary malignant neoplasm of other digestive organs
C7A Malignant neuroendocrine tumors16 codes
- C7A.010 Malignant carcinoid tumor of the duodenum
- C7A.011 Malignant carcinoid tumor of the jejunum
- C7A.012 Malignant carcinoid tumor of the ileum
- C7A.019 Malignant carcinoid tumor of the small intestine, unspecified portion
- C7A.020 Malignant carcinoid tumor of the appendix
- C7A.021 Malignant carcinoid tumor of the cecum
- C7A.022 Malignant carcinoid tumor of the ascending colon
- C7A.023 Malignant carcinoid tumor of the transverse colon
- C7A.024 Malignant carcinoid tumor of the descending colon
- C7A.025 Malignant carcinoid tumor of the sigmoid colon
- C7A.026 Malignant carcinoid tumor of the rectum
- C7A.029 Malignant carcinoid tumor of the large intestine, unspecified portion
- C7A.092 Malignant carcinoid tumor of the stomach
- C7A.094 Malignant carcinoid tumor of the foregut, unspecified
- C7A.095 Malignant carcinoid tumor of the midgut, unspecified
- C7A.096 Malignant carcinoid tumor of the hindgut, unspecified
C7B Secondary neuroendocrine tumors1 code
- C7B.04 Secondary carcinoid tumors of peritoneum
D00 Carcinoma in situ of oral cavity, esophagus and stomach2 codes
D01 Carcinoma in situ of other and unspecified digestive organs8 codes
- D01.0 Carcinoma in situ of colon
- D01.1 Carcinoma in situ of rectosigmoid junction
- D01.2 Carcinoma in situ of rectum
- D01.3 Carcinoma in situ of anus and anal canal
- D01.40 Carcinoma in situ of unspecified part of intestine
- D01.49 Carcinoma in situ of other parts of intestine
- D01.7 Carcinoma in situ of other specified digestive organs
- D01.9 Carcinoma in situ of digestive organ, unspecified
D37 Neoplasm of uncertain behavior of oral cavity and digestive organs7 codes
- D37.1 Neoplasm of uncertain behavior of stomach
- D37.2 Neoplasm of uncertain behavior of small intestine
- D37.3 Neoplasm of uncertain behavior of appendix
- D37.4 Neoplasm of uncertain behavior of colon
- D37.5 Neoplasm of uncertain behavior of rectum
- D37.8 Neoplasm of uncertain behavior of other specified digestive organs
- D37.9 Neoplasm of uncertain behavior of digestive organ, unspecified
D48 Neoplasm of uncertain behavior of other and unspecified sites2 codes
D49 Neoplasms of unspecified behavior1 code
- D49.0 Neoplasm of unspecified behavior of digestive system
ICD-10-PCS
Procedure Codes
Procedure codes do not drive assignment for this DRG. DRG 375 is a Medical DRG, assigned from the principal diagnosis above.
Frequently Asked Questions
What is MS-DRG 375?
MS-DRG 375 (Digestive Malignancy with CC) is a medical DRG in MDC 06 (Diseases & Disorders of the Digestive System). Its FY 2026 relative weight is 1.2096 with a geometric mean length of stay of 3.5 days.
What is the difference between DRG 374, 375, 376?
All 3 share the same base category; the severity of secondary diagnoses separates them: 374 (with MCC), 375 (with CC), 376 (without CC/MCC). A major complication or comorbidity (MCC) places the case in the highest-weighted DRG of the family; a CC in the middle; neither in the lowest.
How many diagnosis codes group to DRG 375?
93 ICD-10-CM principal diagnosis codes group to this DRG, spanning 21 three-character categories.
What is the relative weight of DRG 375?
The FY 2026 relative weight of this DRG is 1.2096, meaning reimbursement of roughly 1.21 times the average Medicare inpatient case. Multiply by a hospital's blended base rate for the approximate payment.
← PreviousDRG 374 – Digestive Malignancy with MCCNext →DRG 376 – Digestive Malignancy without CC/MCC
Source: CMS ICD-10 MS-DRG v43.0 Definitions Manual and the FY 2026 IPPS Final Rule (Table 5), effective October 1, 2025 through September 30, 2026. We publish the DRG assignments as CMS defines them and add the navigation, search, and code links.
