Neoplasms of unspecified behavior (D49)

Browse all the diagnosis codes used for neoplasms of unspecified behavior (d49). For easy navigation, the diagnosis codes are sorted in alphabetical order and grouped by sections. Each section is clearly marked with its description, and the corresponding three-digit code range. This format makes it simple to browse diagnosis codes in this chapter or section and find what you're looking for. We've also added green checkmark icons to label billable codes, and red warning icons for non-billable ones. This makes it easy to identify which codes can be billed.

Clinical Information

Cerebrospinal Fluid Rhinorrhea - Discharge of cerebrospinal fluid through the nose. Common etiologies include trauma, neoplasms, and prior surgery, although the condition may occur spontaneously. (Otolaryngol Head Neck Surg 1997 Apr;116(4):442-9)

Dermatomyositis - A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)

Limbic Encephalitis - A paraneoplastic syndrome marked by degeneration of neurons in the LIMBIC SYSTEM. Clinical features include HALLUCINATIONS, loss of EPISODIC MEMORY; ANOSMIA; AGEUSIA; TEMPORAL LOBE EPILEPSY; DEMENTIA; and affective disturbance (depression). Circulating anti-neuronal antibodies (e.g., anti-Hu; anti-Yo; anti-Ri; and anti-Ma2) and small cell lung carcinomas or testicular carcinoma are frequently associated with this syndrome.

Paraneoplastic Cerebellar Degeneration - Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)

Polymyositis - Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)

Thymoma - A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)

Instructional Notations


This note appears immediately under a three character code title to further define, or give examples of, the content of the category.

  • 'growth' NOS
  • neoplasm NOS
  • new growth NOS
  • tumor NOS

Type 1 Excludes

A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.

  • neoplasms of uncertain behavior D37 D44 D48

  • Category D49 classifies by site neoplasms of unspecified morphology and behavior. The term 'mass', unless otherwise stated, is not to be regarded as a neoplastic growth.
  • Neoplasms (C00–D49)

    • Neoplasms of unspecified behavior (D49)

        • Neoplasms of unspecified behavior (D49)

        • D49 Neoplasms of unspecified behavior
        • D49.0 Neoplasm of unspecified behavior of digestive system
        • D49.1 Neoplasm of unspecified behavior of respiratory system
        • D49.2 Neoplasm of unspecified behavior of bone, soft tissue, and skin
        • D49.3 Neoplasm of unspecified behavior of breast
        • D49.4 Neoplasm of unspecified behavior of bladder
        • D49.5 Neoplasm of unspecified behavior of other genitourinary organs
        • D49.51 Neoplasm of unspecified behavior of kidney
        • D49.511 Neoplasm of unspecified behavior of right kidney
        • D49.512 Neoplasm of unspecified behavior of left kidney
        • D49.519 Neoplasm of unspecified behavior of unspecified kidney
        • D49.59 Neoplasm of unspecified behavior of other genitourinary organ
        • D49.6 Neoplasm of unspecified behavior of brain
        • D49.7 Neoplasm of unspecified behavior of endocrine glands and other parts of nervous system
        • D49.8 Neoplasm of unspecified behavior of other specified sites
        • D49.81 Neoplasm of unspecified behavior of retina and choroid
        • D49.89 Neoplasm of unspecified behavior of other specified sites
        • D49.9 Neoplasm of unspecified behavior of unspecified site