Malignant neoplasms of mesothelial and soft tissue (C45-C49) ICD-10-CM
The C45–C49 section covers malignant neoplasms of mesothelial and soft tissue with 63 ICD-10-CM diagnosis codes, of which 52 are billable in fiscal year 2026. The section is organized into the 5 code ranges listed below.
Code Ranges in This Section 5 ranges · 63 codes
The info icon previews the code ranges inside each row and its instructional notations from the official Tabular List.
About the C45–C49 Code Range
ICD-10 codes C45-C49 cover malignant neoplasms arising from mesothelial tissue, soft tissues, peripheral nerves, and connective tissues. These codes specifically identify different types of cancers such as mesothelioma, Kaposi's sarcoma, malignant peripheral nerve tumors, retroperitoneal cancers, and various soft tissue sarcomas.
The range includes mesothelioma (C45), with detailed codes for pleura (C45.0), peritoneum (C45.1), pericardium (C45.2), and other less common sites, providing precise classification for tumors of the mesothelial lining. Kaposi's sarcoma (C46) is categorized by affected body regions like skin, soft tissue, lung, and gastrointestinal sites, helping in identifying this vascular tumor associated with immunodeficiency. Malignant neoplasms of peripheral nerves and the autonomic nervous system (C47) are further divided by anatomical location (head, limbs, thorax, abdomen, pelvis, and trunk) and specify right, left, or unspecified limbs for accuracy. The codes also include malignant retroperitoneal and peritoneal tumors (C48), distinguishing specific peritoneal sites and retroperitoneal regions. Additionally, malignant neoplasms of other connective and soft tissues (C49) focus on tumors involving soft tissue and connective tissue across body regions such as head, limbs, trunk, and pelvis. This section also includes gastrointestinal stromal tumors (C49.A), which are important in identifying primary tumors of the digestive tract's connective tissues. These codes assist coders and clinicians in precisely documenting distinct malignant soft tissue tumors for proper diagnosis, treatment planning, and research.
Questions About This Page
How many codes are in the C45-C49 range?
The C45-C49 range contains 63 ICD-10-CM diagnosis codes in FY 2026. 52 of them are billable, and the rest are category headers that organize the section.
What conditions does C45-C49 cover?
The range covers malignant neoplasms of mesothelial and soft tissue. The code ranges listed above break it into groups of related conditions, and each one links to its own page with the full code list.
Related References
Source: CMS FY 2026 ICD-10-CM Tabular List and order file, effective October 1, 2025 through September 30, 2026.
