ICD-10-CM Code C25.4

Malignant neoplasm of endocrine pancreas

Version 2021 Billable Code Neoplasm Malignant Primary

Valid for Submission

C25.4 is a billable code used to specify a medical diagnosis of malignant neoplasm of endocrine pancreas. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code C25.4 might also be used to specify conditions or terms like adenocarcinoma of pancreas, carcinoma of endocrine pancreas, carcinoma of pancreas, hyperinsulinemia due to malignant insulinoma, malignant insulinoma, malignant tumor of endocrine pancreas, etc

The following anatomical sites found in the Table of Neoplasms apply to this code given the correct histological behavior: Neoplasm, neoplastic insular tissue (pancreas) or Neoplasm, neoplastic islands or islets of Langerhans or Neoplasm, neoplastic Langerhans, islands or islets or Neoplasm, neoplastic pancreas islet cells .

ICD-10:C25.4
Short Description:Malignant neoplasm of endocrine pancreas
Long Description:Malignant neoplasm of endocrine pancreas

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code C25.4:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Malignant neoplasm of islets of Langerhans

Use Additional Code

Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
  • code to identify any functional activity.

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code C25.4 are found in the index:


Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adenocarcinoma of pancreas
  • Carcinoma of endocrine pancreas
  • Carcinoma of pancreas
  • Hyperinsulinemia due to malignant insulinoma
  • Malignant insulinoma
  • Malignant tumor of endocrine pancreas
  • Malignant tumor of Islets of Langerhans
  • Primary adenocarcinoma of pancreas
  • Primary malignant epithelial neoplasm of endocrine gland
  • Primary malignant neoplasm of islets of Langerhans

Diagnostic Related Groups

The ICD-10 code C25.4 is grouped in the following groups for version MS-DRG V38.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2021.

  • 435 - MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH MCC
  • 436 - MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH CC
  • 437 - MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITHOUT CC/MCC

Convert C25.4 to ICD-9

  • 157.4 - Mal neo islet langerhans

Code Classification

  • Neoplasms (C00–D48)
    • Malignant neoplasms of digestive organs (C15-C26)
      • Malignant neoplasm of pancreas (C25)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Table of Neoplasms

The code C25.4 is included in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

Neoplasm, neoplastic Malignant
Primary
Malignant
Secondary
CaInSitu Benign Uncertain
Behavior
Unspecified
Behavior
»Neoplasm, neoplastic
  »insular tissue (pancreas)
C25.4C78.89D01.7D13.7D37.8D49.0
»Neoplasm, neoplastic
  »islands or islets of Langerhans
C25.4C78.89D01.7D13.7D37.8D49.0
»Neoplasm, neoplastic
  »Langerhans, islands or islets
C25.4C78.89D01.7D13.7D37.8D49.0
»Neoplasm, neoplastic
  »pancreas
    »islet cells
C25.4C78.89D01.7D13.7D37.8D49.0

Information for Patients


Pancreatic Cancer

The pancreas is a gland behind your stomach and in front of your spine. It produces the juices that help break down food and the hormones that help control blood sugar levels. Pancreatic cancer usually begins in the cells that produce the juices. Some risk factors for developing pancreatic cancer include

  • Smoking
  • Long-term diabetes
  • Chronic pancreatitis
  • Certain hereditary disorders

Pancreatic cancer is hard to catch early. It doesn't cause symptoms right away. When you do get symptoms, they are often vague or you may not notice them. They include yellowing of the skin and eyes, pain in the abdomen and back, weight loss and fatigue. Also, because the pancreas is hidden behind other organs, health care providers cannot see or feel the tumors during routine exams. Doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose it.

Because it is often found late and it spreads quickly, pancreatic cancer can be hard to treat. Possible treatments include surgery, radiation, chemotherapy, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells.

NIH: National Cancer Institute

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