ICD-10 Diagnosis Code C25.4

Malignant neoplasm of endocrine pancreas

Diagnosis Code C25.4

ICD-10: C25.4
Short Description: Malignant neoplasm of endocrine pancreas
Long Description: Malignant neoplasm of endocrine pancreas
This is the 2019 version of the ICD-10-CM diagnosis code C25.4

Valid for Submission
The code C25.4 is valid for submission for HIPAA-covered transactions.

Code Classification
  • Neoplasms (C00–D48)
    • Malignant neoplasms of digestive organs (C15-C26)
      • Malignant neoplasm of pancreas (C25)

Information for Medical Professionals

Diagnostic Related Groups
The diagnosis code C25.4 is grouped in the following Diagnostic Related Group(s) (MS-DRG V35.0)

  • 435 - MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH MCC
  • 436 - MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH CC
  • 437 - MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITHOUT CC/MCC

Convert to ICD-9
  • 157.4 - Mal neo islet langerhans

Synonyms
  • Adenocarcinoma of pancreas
  • Carcinoma of endocrine pancreas
  • Carcinoma of pancreas
  • Malignant insulinoma
  • Malignant tumor of endocrine pancreas
  • Malignant tumor of Islets of Langerhans
  • Neoplasm of islets of Langerhans
  • Primary adenocarcinoma of pancreas
  • Primary malignant epithelial neoplasm of endocrine gland
  • Primary malignant neoplasm of islets of Langerhans

Index of Diseases and Injuries
References found for the code C25.4 in the Index of Diseases and Injuries:

  • Inclusion Terms:
    • Malignant neoplasm of islets of Langerhans

Table of Neoplasms

The code C25.4 is included in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

The Tabular must be reviewed for the complete diagnosis code.

Neoplasm, neoplastic Malignant
Primary
Malignant
Secondary
CaInSitu Benign Uncertain
Behavior
Unspecified
Behavior
»insular tissue (pancreas)
C25.4C78.89D01.7D13.7D37.8D49.0
»islands or islets of Langerhans
C25.4C78.89D01.7D13.7D37.8D49.0
»Langerhans, islands or islets
C25.4C78.89D01.7D13.7D37.8D49.0
»pancreas
  »islet cells
C25.4C78.89D01.7D13.7D37.8D49.0

Information for Patients


Pancreatic Cancer

The pancreas is a gland behind your stomach and in front of your spine. It produces the juices that help break down food and the hormones that help control blood sugar levels. Pancreatic cancer usually begins in the cells that produce the juices. Some risk factors for developing pancreatic cancer include

  • Smoking
  • Long-term diabetes
  • Chronic pancreatitis
  • Certain hereditary disorders

Pancreatic cancer is hard to catch early. It doesn't cause symptoms right away. When you do get symptoms, they are often vague or you may not notice them. They include yellowing of the skin and eyes, pain in the abdomen and back, weight loss and fatigue. Also, because the pancreas is hidden behind other organs, health care providers cannot see or feel the tumors during routine exams. Doctors use a physical exam, blood tests, imaging tests, and a biopsy to diagnose it.

Because it is often found late and it spreads quickly, pancreatic cancer can be hard to treat. Possible treatments include surgery, radiation, chemotherapy, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells.

NIH: National Cancer Institute

  • After chemotherapy - discharge (Medical Encyclopedia)
  • Amylase - urine (Medical Encyclopedia)
  • Pancreatic cancer (Medical Encyclopedia)
  • Understanding Chemotherapy - NIH - Easy-to-Read (National Cancer Institute)
  • What to Know about External Beam Radiation Therapy - NIH - Easy-to-Read (National Cancer Institute)
  • Zollinger-Ellison syndrome (Medical Encyclopedia)

[Read More]

ICD-10 Footnotes

General Equivalence Map Definitions
The ICD-10 and ICD-9 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.

Index of Diseases and Injuries Definitions

  • And - The word "and" should be interpreted to mean either "and" or "or" when it appears in a title.
  • Code also note - A "code also" note instructs that two codes may be required to fully describe a condition, but this note does not provide sequencing direction.
  • Code first - Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
  • Type 1 Excludes Notes - A type 1 Excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Type 2 Excludes Notes - A type 2 Excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
  • Includes Notes - This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
  • Inclusion terms - List of terms is included under some codes. These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • NEC "Not elsewhere classifiable" - This abbreviation in the Alphabetic Index represents "other specified". When a specific code is not available for a condition, the Alphabetic Index directs the coder to the "other specified” code in the Tabular List.
  • NOS "Not otherwise specified" - This abbreviation is the equivalent of unspecified.
  • See - The "see" instruction following a main term in the Alphabetic Index indicates that another term should be referenced. It is necessary to go to the main term referenced with the "see" note to locate the correct code.
  • See Also - A "see also" instruction following a main term in the Alphabetic Index instructs that there is another main term that may also be referenced that may provide additional Alphabetic Index entries that may be useful. It is not necessary to follow the "see also" note when the original main term provides the necessary code.
  • 7th Characters - Certain ICD-10-CM categories have applicable 7th characters. The applicable 7th character is required for all codes within the category, or as the notes in the Tabular List instruct. The 7th character must always be the 7th character in the data field. If a code that requires a 7th character is not 6 characters, a placeholder X must be used to fill in the empty characters.
  • With - The word "with" should be interpreted to mean "associated with" or "due to" when it appears in a code title, the Alphabetic Index, or an instructional note in the Tabular List. The word "with" in the Alphabetic Index is sequenced immediately following the main term, not in alphabetical order.

Present on Admission
The Present on Admission (POA) indicator is used for diagnosis codes included in claims involving inpatient admissions to general acute care hospitals. POA indicators must be reported to CMS on each claim to facilitate the grouping of diagnoses codes into the proper Diagnostic Related Groups (DRG). CMS publishes a listing of specific diagnosis codes that are exempt from the POA reporting requirement.

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