2024 ICD-10-CM Diagnosis Code C22.1

Intrahepatic bile duct carcinoma

ICD-10-CM Code:
ICD-10 Code for:
Intrahepatic bile duct carcinoma
Is Billable?
Yes - Valid for Submission
Chronic Condition Indicator: [1]
Code Navigator:

Code Classification

  • Neoplasms
    • Malignant neoplasms of digestive organs
      • Malignant neoplasm of liver and intrahepatic bile ducts

C22.1 is a billable diagnosis code used to specify a medical diagnosis of intrahepatic bile duct carcinoma. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024.

The following anatomical sites found in the Table of Neoplasms reference this diagnosis code given the correct histological behavior: Neoplasm, neoplastic bile or biliary (tract) canaliculi (biliferi) (intrahepatic) ; Neoplasm, neoplastic bile or biliary (tract) canals, interlobular ; Neoplasm, neoplastic bile or biliary (tract) duct or passage (common) (cystic) (extrahepatic) interlobular ; Neoplasm, neoplastic bile or biliary (tract) duct or passage (common) (cystic) (extrahepatic) intrahepatic ; Neoplasm, neoplastic canaliculi, biliary (biliferi) (intrahepatic) ; Neoplasm, neoplastic cholangiole ; Neoplasm, neoplastic gall duct (extrahepatic) intrahepatic ; etc

Approximate Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adenocarcinoma of liver and intrahepatic biliary tract
  • Cholangiocarcinoma of biliary tract
  • Cholangiocarcinoma of biliary tract
  • Cholangiocarcinoma of intrahepatic biliary tract
  • Intrahepatic bile duct carcinoma
  • Malignant neoplasm of interlobular bile ducts
  • Malignant neoplasm of intrahepatic canaliculi
  • Malignant neoplasm of intrahepatic gall duct
  • Primary adenocarcinoma of bile duct
  • Primary adenocarcinoma of intrahepatic bile duct
  • Primary carcinoma liver and/or biliary system
  • Primary carcinoma of bile duct
  • Primary cholangiocarcinoma of intrahepatic biliary tract
  • Primary cystadenocarcinoma of intrahepatic bile duct
  • Primary intrahepatic bile duct carcinoma
  • Primary malignant neoplasm of intrahepatic bile duct
  • Squamous cell carcinoma of liver and intrahepatic biliary tract
  • Undifferentiated carcinoma of liver and intrahepatic biliary tract

Clinical Classification

Index to Diseases and Injuries References

The following annotation back-references for this diagnosis code are found in the injuries and diseases index. The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10-CM code(s).

Convert C22.1 to ICD-9-CM

  • ICD-9-CM Code: 155.1 - Mal neo intrahepat ducts

Table of Neoplasms

This code is referenced in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

Neoplasm, neoplastic Malignant
CaInSitu Benign Uncertain
»Neoplasm, neoplastic
  »bile or biliary (tract)
    »canaliculi (biliferi) (intrahepatic)
»Neoplasm, neoplastic
  »bile or biliary (tract)
    »canals, interlobular
»Neoplasm, neoplastic
  »bile or biliary (tract)
    »duct or passage (common) (cystic) (extrahepatic)
»Neoplasm, neoplastic
  »bile or biliary (tract)
    »duct or passage (common) (cystic) (extrahepatic)
»Neoplasm, neoplastic
  »canaliculi, biliary (biliferi) (intrahepatic)
»Neoplasm, neoplastic
»Neoplasm, neoplastic
  »gall duct (extrahepatic)
»Neoplasm, neoplastic
  »intrahepatic (bile) duct

Patient Education

Bile Duct Cancer

Your liver makes a digestive juice called bile. Your gallbladder stores it between meals. When you eat, your gallbladder pushes the bile into tubes called bile ducts. They carry the bile to your small intestine. The bile helps break down fat. It also helps the liver get rid of toxins and wastes.

Bile duct cancer is rare. It can happen in the parts of the bile ducts that are outside or inside the liver. Cancer of the bile duct outside of the liver is much more common. Risk factors include having inflammation of the bile duct, ulcerative colitis, and some liver diseases.

Symptoms can include:

  • Jaundice
  • Itchy skin
  • Fever
  • Abdominal pain

Tests to diagnose bile duct cancer may include a physical exam, imaging tests of the liver and bile ducts, blood tests, and a biopsy.

Treatments include surgery, radiation therapy, and chemotherapy.

NIH: National Cancer Institute

[Learn More in MedlinePlus]

Liver Cancer

Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver.

Risk factors for primary liver cancer include :

  • Having hepatitis B or C
  • Heavy alcohol use
  • Having cirrhosis, or scarring of the liver
  • Having hemochromatosis, an iron storage disease
  • Obesity and diabetes

Symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. However, you may not have symptoms until the cancer is advanced. This makes it harder to treat. Doctors use tests that examine the liver and the blood to diagnose liver cancer. Treatment options include surgery, radiation, chemotherapy, or liver transplantation.

NIH: National Cancer Institute

[Learn More in MedlinePlus]


Cholangiocarcinoma is a group of cancers that begin in the bile ducts. Bile ducts are branched tubes that connect the liver and gallbladder to the small intestine. They carry bile, which is a fluid that helps the body digest fats that are in food. Bile is made in the liver and stored in the gallbladder before being released in the small intestine after a person eats.

Cholangiocarcinoma is classified by its location in relation to the liver. Intrahepatic cholangiocarcinoma begins in the small bile ducts within the liver. This is the least common form of the disease, accounting for less than 10 percent of all cases. Perihilar cholangiocarcinoma (also known as a Klatskin tumor) begins in an area called the hilum, where the right and left major bile ducts join and leave the liver. It is the most common form of the disease, accounting for more than half of all cases. The remaining cases are classified as distal cholangiocarcinomas, which begin in bile ducts outside the liver. The perihilar and distal forms of the disease, which both occur outside the liver, are sometimes grouped together and called extrahepatic cholangiocarcinoma.

The three types of cholangiocarcinoma do not usually cause any symptoms in their early stages, and this cancer is usually not diagnosed until it has already spread beyond the bile ducts to other tissues. Symptoms often result when bile ducts become blocked by the tumor. The most common symptom is jaundice, in which the skin and whites of the eyes turn yellow. Other symptoms can include extreme tiredness (fatigue), itching, dark-colored urine, loss of appetite, unintentional weight loss, abdominal pain, and light-colored and greasy stools. These symptoms are described as "nonspecific" because they can be features of many different diseases.

Most people who develop cholangiocarcinoma are older than 65. Because this cancer is often not discovered until it has already spread, it can be challenging to treat effectively. Affected individuals can survive for several months to several years after diagnosis, depending on the location of the cancer and how advanced it is.

[Learn More in MedlinePlus]

What is Bile Duct Cancer (Cholangiocarcinoma)?

Learn about bile duct cancer (cholangiocarcinoma) risk factors, symptoms, tests to diagnose, factors affecting prognosis, staging, and treatment.
[Learn More in MedlinePlus]

Code History

  • FY 2024 - No Change, effective from 10/1/2023 through 9/30/2024
  • FY 2023 - No Change, effective from 10/1/2022 through 9/30/2023
  • FY 2022 - No Change, effective from 10/1/2021 through 9/30/2022
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016. This was the first year ICD-10-CM was implemented into the HIPAA code set.


[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.