ICD-10-CM Code C22.1

Intrahepatic bile duct carcinoma

Version 2021 Billable Code Neoplasm Malignant Primary

Valid for Submission

C22.1 is a billable code used to specify a medical diagnosis of intrahepatic bile duct carcinoma. The code is valid for the fiscal year 2021 for the submission of HIPAA-covered transactions. The ICD-10-CM code C22.1 might also be used to specify conditions or terms like adenocarcinoma of liver, adenocarcinoma of liver, adenocarcinoma of liver and intrahepatic biliary tract, cholangiocarcinoma of biliary tract, intrahepatic bile duct carcinoma, malignant neoplasm of interlobular bile ducts, etc

The following anatomical sites found in the Table of Neoplasms apply to this code given the correct histological behavior: Neoplasm, neoplastic bile or biliary (tract) canaliculi (biliferi) (intrahepatic) ; Neoplasm, neoplastic bile or biliary (tract) canals, interlobular ; Neoplasm, neoplastic bile or biliary (tract) duct or passage (common) (cystic) (extrahepatic) interlobular ; Neoplasm, neoplastic bile or biliary (tract) duct or passage (common) (cystic) (extrahepatic) intrahepatic ; Neoplasm, neoplastic canaliculi, biliary (biliferi) (intrahepatic) ; Neoplasm, neoplastic cholangiole ; Neoplasm, neoplastic gall duct (extrahepatic) intrahepatic ; etc

ICD-10:C22.1
Short Description:Intrahepatic bile duct carcinoma
Long Description:Intrahepatic bile duct carcinoma

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code C22.1:

Inclusion Terms

Inclusion Terms
These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • Cholangiocarcinoma

Type 1 Excludes

Type 1 Excludes
A type 1 excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • malignant neoplasm of hepatic duct C24.0

Index to Diseases and Injuries

The Index to Diseases and Injuries is an alphabetical listing of medical terms, with each term mapped to one or more ICD-10 code(s). The following references for the code C22.1 are found in the index:


Synonyms

The following clinical terms are approximate synonyms or lay terms that might be used to identify the correct diagnosis code:

  • Adenocarcinoma of liver
  • Adenocarcinoma of liver
  • Adenocarcinoma of liver and intrahepatic biliary tract
  • Cholangiocarcinoma of biliary tract
  • Intrahepatic bile duct carcinoma
  • Malignant neoplasm of interlobular bile ducts
  • Malignant neoplasm of intrahepatic canaliculi
  • Malignant neoplasm of intrahepatic gall duct
  • Malignant neoplasm of intrahepatic gall duct
  • Malignant neoplasm of intrahepatic gall duct
  • Malignant neoplasm of intrahepatic gall duct
  • Malignant neoplasm of liver and intrahepatic bile ducts
  • Primary cholangiocarcinoma of intrahepatic biliary tract
  • Primary malignant neoplasm of intrahepatic bile duct
  • Primary malignant neoplasm of intrahepatic bile duct
  • Primary malignant neoplasm of intrahepatic bile duct
  • Squamous cell carcinoma of liver and intrahepatic biliary tract
  • Undifferentiated carcinoma of liver and intrahepatic biliary tract

Diagnostic Related Groups

The ICD-10 code C22.1 is grouped in the following groups for version MS-DRG V38.0 What are Diagnostic Related Groups?
The Diagnostic Related Groups (DRGs) are a patient classification scheme which provides a means of relating the type of patients a hospital treats. The DRGs divides all possible principal diagnoses into mutually exclusive principal diagnosis areas referred to as Major Diagnostic Categories (MDC).
applicable from 10/01/2020 through 09/30/2021.

  • 435 - MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH MCC
  • 436 - MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITH CC
  • 437 - MALIGNANCY OF HEPATOBILIARY SYSTEM OR PANCREAS WITHOUT CC/MCC

Convert C22.1 to ICD-9

  • 155.1 - Mal neo intrahepat ducts

Code Classification

  • Neoplasms (C00–D48)
    • Malignant neoplasms of digestive organs (C15-C26)
      • Malignant neoplasm of liver and intrahepatic bile ducts (C22)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020
  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021

Table of Neoplasms

The code C22.1 is included in the table of neoplasms by anatomical site. For each site there are six possible code numbers according to whether the neoplasm in question is malignant, benign, in situ, of uncertain behavior, or of unspecified nature. The description of the neoplasm will often indicate which of the six columns is appropriate.

Where such descriptors are not present, the remainder of the Index should be consulted where guidance is given to the appropriate column for each morphological (histological) variety listed. However, the guidance in the Index can be overridden if one of the descriptors mentioned above is present.

Neoplasm, neoplastic Malignant
Primary
Malignant
Secondary
CaInSitu Benign Uncertain
Behavior
Unspecified
Behavior
»Neoplasm, neoplastic
  »bile or biliary (tract)
    »canaliculi (biliferi) (intrahepatic)
C22.1C78.7D01.5D13.4D37.6D49.0
»Neoplasm, neoplastic
  »bile or biliary (tract)
    »canals, interlobular
C22.1C78.89D01.5D13.4D37.6D49.0
»Neoplasm, neoplastic
  »bile or biliary (tract)
    »duct or passage (common) (cystic) (extrahepatic)
      »interlobular
C22.1C78.89D01.5D13.4D37.6D49.0
»Neoplasm, neoplastic
  »bile or biliary (tract)
    »duct or passage (common) (cystic) (extrahepatic)
      »intrahepatic
C22.1C78.7D01.5D13.4D37.6D49.0
»Neoplasm, neoplastic
  »canaliculi, biliary (biliferi) (intrahepatic)
C22.1C78.7D01.5D13.4D37.6D49.0
»Neoplasm, neoplastic
  »cholangiole
C22.1C78.89D01.5D13.4D37.6D49.0
»Neoplasm, neoplastic
  »gall duct (extrahepatic)
    »intrahepatic
C22.1C78.7D01.5D13.4D37.6D49.0
»Neoplasm, neoplastic
  »intrahepatic (bile) duct
C22.1C78.7D01.5D13.4D37.6D49.0

Information for Patients


Bile Duct Cancer

Also called: Cholangiocarcinoma

Your liver makes a digestive juice called bile. Your gallbladder stores it between meals. When you eat, your gallbladder pushes the bile into tubes called bile ducts. They carry the bile to your small intestine. The bile helps break down fat. It also helps the liver get rid of toxins and wastes.

Bile duct cancer is rare. It can happen in the parts of the bile ducts that are outside or inside the liver. Cancer of the bile duct outside of the liver is much more common. Risk factors include having inflammation of the bile duct, ulcerative colitis, and some liver diseases.

Symptoms can include

  • Jaundice
  • Itchy skin
  • Fever
  • Abdominal pain

Tests to diagnose bile duct cancer may include a physical exam, imaging tests of the liver and bile ducts, blood tests, and a biopsy.

Treatments include surgery, radiation therapy, and chemotherapy.

NIH: National Cancer Institute

  • Biliary stricture (Medical Encyclopedia)
  • Cholangiocarcinoma (Medical Encyclopedia)
  • ERCP (Medical Encyclopedia)

[Learn More]

Liver Cancer

Also called: Hepatocellular carcinoma

Your liver is the largest organ inside your body. It helps your body digest food, store energy, and remove poisons. Primary liver cancer starts in the liver. Metastatic liver cancer starts somewhere else and spreads to your liver.

Risk factors for primary liver cancer include

  • Having hepatitis B or C
  • Heavy alcohol use
  • Having cirrhosis, or scarring of the liver
  • Having hemochromatosis, an iron storage disease
  • Obesity and diabetes

Symptoms can include a lump or pain on the right side of your abdomen and yellowing of the skin. However, you may not have symptoms until the cancer is advanced. This makes it harder to treat. Doctors use tests that examine the liver and the blood to diagnose liver cancer. Treatment options include surgery, radiation, chemotherapy, or liver transplantation.

NIH: National Cancer Institute

  • Abdominal tap (Medical Encyclopedia)
  • After chemotherapy - discharge (Medical Encyclopedia)
  • Hepatocellular carcinoma (Medical Encyclopedia)
  • Liver metastases (Medical Encyclopedia)

[Learn More]

Cholangiocarcinoma Cholangiocarcinoma is a group of cancers that begin in the bile ducts. Bile ducts are branched tubes that connect the liver and gallbladder to the small intestine. They carry bile, which is a fluid that helps the body digest fats that are in food. Bile is made in the liver and stored in the gallbladder before being released in the small intestine after a person eats.Cholangiocarcinoma is classified by its location in relation to the liver. Intrahepatic cholangiocarcinoma begins in the small bile ducts within the liver. This is the least common form of the disease, accounting for less than 10 percent of all cases. Perihilar cholangiocarcinoma (also known as a Klatskin tumor) begins in an area called the hilum, where the right and left major bile ducts join and leave the liver. It is the most common form of the disease, accounting for more than half of all cases. The remaining cases are classified as distal cholangiocarcinomas, which begin in bile ducts outside the liver. The perihilar and distal forms of the disease, which both occur outside the liver, are sometimes grouped together and called extrahepatic cholangiocarcinoma.The three types of cholangiocarcinoma do not usually cause any symptoms in their early stages, and this cancer is usually not diagnosed until it has already spread beyond the bile ducts to other tissues. Symptoms often result when bile ducts become blocked by the tumor. The most common symptom is jaundice, in which the skin and whites of the eyes turn yellow. Other symptoms can include extreme tiredness (fatigue), itching, dark-colored urine, loss of appetite, unintentional weight loss, abdominal pain, and light-colored and greasy stools. These symptoms are described as "nonspecific" because they can be features of many different diseases.Most people who develop cholangiocarcinoma are older than 65. Because this cancer is often not discovered until it has already spread, it can be challenging to treat effectively. Affected individuals can survive for several months to several years after diagnosis, depending on the location of the cancer and how advanced it is.
[Learn More]