2026 ICD-10-CM Diagnosis Code E34.8Other specified endocrine disorders

ICD-10-CM Codes›E00–E89›E20-E35›E34

ICD-10-CM E34.8
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E34.8 is a billable ICD-10-CM diagnosis code for other specified endocrine disorders. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E34.8
Billable Status
Yes — Valid for Submission
Code Describes
Other specified endocrine disorders
Short Description
Other specified endocrine disorders
Same as the full description in the CMS dataset.
Parent Code
E34
Other endocrine disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE34Other endocrine disorders
This CodeE34.8Other specified endocrine disorders

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Abnormal corticosterone
  • Abnormal estradiol
  • Abnormal serotonin
  • Abnormality of serotonin secretion
  • Acrogeria
  • Acroosteolysis
  • Acroosteolysis, keloid-like lesions, premature aging syndrome
  • Aging
  • Atypical Werner syndrome
  • Autoimmune endocrine disease
  • Calcification of pineal gland
  • Complex gonadal endocrine disorder
  • Congenital anomaly of subcutaneous tissue
  • Diabetes mellitus associated with genetic syndrome
  • Diabetes mellitus due to genetic defect in insulin action
  • Disorder of androgen receptor
  • Disorder of endocrine gonad
  • Endocrine alopecia
  • Endocrine andrology disorder
  • Endocrine axis dysfunction
  • Euthyroid Graves orbitopathy
  • General adaptation syndrome
  • Gynecological endocrinology disorder
  • Hereditary acroosteolysis
  • Hutchinson-Gilford syndrome
  • Hypothalamic-pituitary-adrenal axis dysfunction
  • Hypothalamic-pituitary-gonadal axis dysfunction
  • Hypothalamic-pituitary-ovarian axis dysfunction
  • Hypothalamic-pituitary-testicular axis dysfunction
  • Insulin biosynthesis defect
  • Insulin receptor defect
  • Insulin resistance
  • Laminopathy with premature aging
  • Leprechaunism syndrome
  • LMNA-related cardiocutaneous progeria syndrome
  • Macrogenitosomia
  • Macrogenitosomia praecox due to pineal disorder
  • Malabsorption of glucose
  • Mandibular hypoplasia, deafness, progeroid syndrome
  • Marfan's syndrome
  • Mass of endocrine structure
  • Metageria
  • Multiple malformation syndrome with senile-like appearance
  • Neonatal pseudo-hydrocephalic progeroid syndrome
  • Nestor Guillermo progeria syndrome
  • Pineal degeneration
  • Pineal gland disorder
  • Pineal gland dysfunction
  • Premature aging
  • Premature aging syndrome
  • Progeroid and marfanoid aspect, lipodystrophy syndrome
  • Progeroid features, hepatocellular carcinoma predisposition syndrome
  • Progeroid short stature with pigmented nevi
  • Progeroid syndrome Petty type
  • Rabson-Mendenhall syndrome
  • Retinitis pigmentosa, hearing loss, premature aging, short stature, facial dysmorphism syndrome
  • Werner syndrome

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Pineal gland dysfunction
  • Progeria

Type 2 Excludes

  • pseudohypoparathyroidism E20.1

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Calcification
      • pineal gland
    • Cyst(colloid) (mucous) (simple) (retention)
      • epiphysis cerebri
    • Degeneration, degenerative
      • pineal gland
    • Disease, diseased
      • pineal gland
    • Donohue's syndrome
    • Dysfunction
      • pineal gland
    • Gilford-Hutchinson disease
    • Hutchinson-Gilford disease or syndrome
    • Hyperpinealism
    • Hypopinealism
    • Leprechaunism
    • Pellizzi's syndrome
    • Premature
      • aging
    • Premature
      • senility
    • Presenile
      • premature aging
    • Progeria
    • Puberty(development state)
      • premature
        • due to
          • pineal tumor
    • Senile, senility
      • premature
    • Syndrome
      • pineal
    • Syndrome
      • premature senility
    • Syndrome
      • Werner's
    • Werner's disease or syndrome

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • General Adaptation Syndrome

    the sum of all nonspecific systemic reactions of the body to long-continued exposure to systemic stress.

  • Werner Syndrome

    an autosomal recessive disorder that causes premature aging in adults, characterized by sclerodermal skin changes, cataracts, subcutaneous calcification, muscular atrophy, a tendency to diabetes mellitus, aged appearance of the face, baldness, and a high incidence of neoplastic disease.

  • Werner Syndrome Helicase

    a dna-dependent helicase and 3'-5' exonuclease. it has 3'->5' exonuclease activity towards double-stranded dna with a 5'-overhang and binds preferentially to dna substrates containing alternate secondary structures, such as replication forks and holliday junctions. mutations in the wrn gene are associated with werner syndrome.

  • Insulin Resistance

    diminished effectiveness of insulin in lowering blood sugar levels: requiring the use of 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

  • Metabolic Syndrome

    a cluster of symptoms that are risk factors for cardiovascular diseases and type 2 diabetes mellitus. the major components of metabolic syndrome include abdominal obesity; atherogenic dyslipidemia; hypertension; hyperglycemia; insulin resistance; a proinflammatory state; and a prothrombotic (thrombosis) state.

  • Acroosteolysis

    a condition that is characterized by degeneration of the distal phalanges.

  • Homeostatic Model Assessment of Insulin Resistance

    an assessment of beta-cell function and insulin resistance based on fasting blood glucose and insulin concentrations.

  • Hyperandrogenism, Insulin Resistance, Acanthosis Nigricans Syndrome|HAIR-AN Syndrome

    a condition characterized by hyperandrogenism, insulin resistance, and acanthosis nigricans, typically associated with obesity in teenage girls. it is considered to be a subtype of polycystic ovarian syndrome, but may occur in male individuals. etiology is unclear, but some cases may be associated with mutations affecting the tyrosine kinase domain of the insulin receptor.

  • Insulin Receptor Mutation - Associated Insulin Resistance Syndromes

    insulin resistance caused by inactivating mutation(s) in the insr gene encoding the insulin receptor.

  • Insulin Resistance

    decreased sensitivity to circulating insulin which may result in acanthosis nigicrans, elevated insulin level or hyperglycemia.

  • Insulin Resistance Measurement|INSULINR|Insulin Resistance|Insulin Resistance

    the determination of the insulin resistance (cells inability to respond to insulin) in a biological specimen.

  • Insulin Resistance Syndrome

    a cluster of closely related metabolic abnormalities associated with insulin resistance that confer an increased risk of the development of type 2 diabetes and cardiovascular disease. these abnormalities may include obesity, high blood pressure, abnormal cholesterol levels, proteinuria, and/or polycystic ovary syndrome.

  • Insulin Resistant Diabetes Mellitus with Acanthosis Nigricans and Hyperandrogenism|Type A Insulin Resistance Syndrome

    a syndrome of insulin resistance caused by mutation(s) in the insr gene, encoding the insulin receptor. this condition is characterized by a clinical triad of hyperinsulinemia, acanthosis nigricans, and hyperandrogenism without lipodystrophy. this is the least severe of a spectrum of disorders; the other two conditions are rabson-mendenhall syndrome and donohoe syndrome.

  • Obesity-Associated Insulin Resistance

    insulin resistance associated with obesity, which may be attributed in part to impaired insulin signaling in target tissues, or impaired insulin-stimulated glucose transport due to reduced expression of the glucose transporter protein 4.

Patient EducationClinical

Endocrine Diseases

Your endocrine system includes eight major glands throughout your body. These glands make hormones. Hormones are chemical messengers. They travel through your bloodstream to tissues or organs. Hormones work slowly and affect body processes from head to toe. These include:

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E34.8 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
259.8 Endocrine disorders NEC
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E34.8Overview

Is E34.8 (Other endocrine disorders) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other specified endocrine disorders on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E34.8 group to?

When other specified endocrine disorders is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E34.8?

Under the General Equivalence Mappings, other specified endocrine disorders converts to ICD-9-CM 259.8 (endocrine disorders NEC). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Not chronic - A diagnosis code that does not fit the criteria for chronic condition (duration, ongoing medical treatment, and limitations) is considered not chronic. Some codes designated as not chronic are acute conditions. Other diagnosis codes that indicate a possible chronic condition, but for which the duration of the illness is not specified in the code description (i.e., we do not know the condition has lasted 12 months or longer) also are considered not chronic.