ICD-9 Code 259.8

Other specified endocrine disorders

Not Valid for Submission

259.8 is a legacy non-billable code used to specify a medical diagnosis of other specified endocrine disorders. This code was replaced on September 30, 2015 by its ICD-10 equivalent.

ICD-9: 259.8
Short Description:Endocrine disorders NEC
Long Description:Other specified endocrine disorders

Convert 259.8 to ICD-10

The following crosswalk between ICD-9 to ICD-10 is based based on the General Equivalence Mappings (GEMS) information:

  • E34.8 - Other specified endocrine disorders

Code Classification

  • Endocrine, nutritional and metabolic diseases, and immunity disorders (240–279)
    • Diseases of other endocrine glands (249-259)
      • 259 Other endocrine disorders

Information for Medical Professionals


  • Abnormal 17-ketosteroids
  • Abnormal 3,3' diiodothyronine
  • Abnormal corticotropin releasing factor
  • Abnormal oxytocin
  • Abnormal pituitary follicle stimulating hormone
  • Abnormal pituitary gonadotropin
  • Abnormal polypeptide hormone
  • Abnormal protein hormone
  • Abnormal steroid hormone
  • Abnormal testosterone
  • Acrogeria
  • Androgen resistance syndrome
  • Combination of endocrine dysfunction
  • Complex gonadal endocrine disorder
  • Complex pituitary endocrine disorder
  • Congenital leptin deficiency
  • Cyst of pineal gland
  • Decreased hormonal activity
  • Disorder of endocrine receptor
  • Endocrine andrology disorder
  • Endocrine axis dysfunction
  • Endocrine disorder related to puberty
  • Extreme insulin resistance with acanthosis nigricans, hirsutism AND autoantibodies to the insulin receptors
  • Functional disease of the central nervous system with neuroendocrine disturbance
  • Gynecological endocrinology disorder
  • Hormonal resistance
  • Hormone absence
  • Hutchinson-Gilford syndrome
  • Hyperthermia-hyperphagia-hypothyroidism syndrome
  • Hypothalamic obesity
  • Hypothalamic pseudopuberty
  • Hypothalamic-pituitary-adrenal axis dysfunction
  • Hypothalamic-pituitary-gonadal axis dysfunction
  • Hypothalamic-pituitary-ovarian axis dysfunction
  • Hypothalamic-pituitary-testicular axis dysfunction
  • Increased hormonal requirement
  • Insulin receptor defect
  • Leprechaunism syndrome
  • Metageria
  • Mullerian inhibiting factor deficiency
  • Myopathy with deficiency of iron-sulfur cluster assembly enzyme
  • Neonatal pseudo-hydrocephalic progeroid syndrome
  • Non-pancreatic hypersecretion of intestinal hormones
  • Pineal gland disorder
  • Pineal gland dysfunction
  • Pineal hyperplasia AND diabetes mellitus syndrome
  • Placental aromatase deficiency
  • Premature aging syndrome
  • Pseudohypoaldosteronism, type 1, recessive form
  • Pseudopuberty
  • Refetoff syndrome
  • Werner syndrome
  • Wrinkly skin syndrome

Index to Diseases and Injuries

References found for the code 259.8 in the Index of Diseases and Injuries:

Information for Patients

Endocrine Diseases

Your endocrine system includes eight major glands throughout your body. These glands make hormones. Hormones are chemical messengers. They travel through your bloodstream to tissues or organs. Hormones work slowly and affect body processes from head to toe. These include:

  • Growth and development
  • Metabolism - digestion, elimination, breathing, blood circulation and maintaining body temperature
  • Sexual function
  • Reproduction
  • Mood

If your hormone levels are too high or too low, you may have a hormone disorder. Hormone diseases also occur if your body does not respond to hormones the way it is supposed to. Stress, infection and changes in your blood's fluid and electrolyte balance can also influence hormone levels.

In the United States, the most common endocrine disease is diabetes. There are many others. They are usually treated by controlling how much hormone your body makes. Hormone supplements can help if the problem is too little of a hormone.

[Read More]

ICD-9 Footnotes

General Equivalence Map Definitions
The ICD-9 and ICD-10 GEMs are used to facilitate linking between the diagnosis codes in ICD-9-CM and the new ICD-10-CM code set. The GEMs are the raw material from which providers, health information vendors and payers can derive specific applied mappings to meet their needs.

  • Approximate Flag - The approximate flag is on, indicating that the relationship between the code in the source system and the code in the target system is an approximate equivalent.
  • No Map Flag - The no map flag indicates that a code in the source system is not linked to any code in the target system.
  • Combination Flag - The combination flag indicates that more than one code in the target system is required to satisfy the full equivalent meaning of a code in the source system.

Index of Diseases and Injuries Definitions

  • And - The word "and" should be interpreted to mean either "and" or "or" when it appears in a title.
  • Code also note - A "code also" note instructs that two codes may be required to fully describe a condition, but this note does not provide sequencing direction.
  • Code first - Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
  • Type 1 Excludes Notes - A type 1 Excludes note is a pure excludes note. It means "NOT CODED HERE!" An Excludes1 note indicates that the code excluded should never be used at the same time as the code above the Excludes1 note. An Excludes1 is used when two conditions cannot occur together, such as a congenital form versus an acquired form of the same condition.
  • Type 2 Excludes Notes - A type 2 Excludes note represents "Not included here". An excludes2 note indicates that the condition excluded is not part of the condition represented by the code, but a patient may have both conditions at the same time. When an Excludes2 note appears under a code, it is acceptable to use both the code and the excluded code together, when appropriate.
  • Includes Notes - This note appears immediately under a three character code title to further define, or give examples of, the content of the category.
  • Inclusion terms - List of terms is included under some codes. These terms are the conditions for which that code is to be used. The terms may be synonyms of the code title, or, in the case of "other specified" codes, the terms are a list of the various conditions assigned to that code. The inclusion terms are not necessarily exhaustive. Additional terms found only in the Alphabetic Index may also be assigned to a code.
  • NEC "Not elsewhere classifiable" - This abbreviation in the Alphabetic Index represents "other specified". When a specific code is not available for a condition, the Alphabetic Index directs the coder to the "other specified” code in the Tabular List.
  • NOS "Not otherwise specified" - This abbreviation is the equivalent of unspecified.
  • See - The "see" instruction following a main term in the Alphabetic Index indicates that another term should be referenced. It is necessary to go to the main term referenced with the "see" note to locate the correct code.
  • See Also - A "see also" instruction following a main term in the Alphabetic Index instructs that there is another main term that may also be referenced that may provide additional Alphabetic Index entries that may be useful. It is not necessary to follow the "see also" note when the original main term provides the necessary code.
  • 7th Characters - Certain ICD-10-CM categories have applicable 7th characters. The applicable 7th character is required for all codes within the category, or as the notes in the Tabular List instruct. The 7th character must always be the 7th character in the data field. If a code that requires a 7th character is not 6 characters, a placeholder X must be used to fill in the empty characters.
  • With - The word "with" should be interpreted to mean "associated with" or "due to" when it appears in a code title, the Alphabetic Index, or an instructional note in the Tabular List. The word "with" in the Alphabetic Index is sequenced immediately following the main term, not in alphabetical order.