2027 ICD-10-CM Diagnosis Code E27.49Other adrenocortical insufficiency

ICD-10-CM Codes›E00–E89›E20-E35›E27

ICD-10-CM E27.49
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E27.49 is a billable ICD-10-CM diagnosis code for other adrenocortical insufficiency. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 22 closely related codes. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

E27.49 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.

Code Identity

ICD-10-CM Code
E27.49
Billable Status
Yes — Valid for Submission
Code Describes
Other adrenocortical insufficiency
Short Description
Other adrenocortical insufficiency
Same as the full description in the CMS dataset.
Parent Code
E27.4
Other and unspecified adrenocortical insufficiency

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE27Other disorders of adrenal gland
This CodeE27.49Other adrenocortical insufficiency

Medicare Risk Adjustment (HCC)Billing

E27.49 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
Dropped in V28 see all codes that no longer risk-adjust
Prior Model (CMS-HCC V24)
HCC 23
V24 retired last contributed to a Medicare Advantage risk score in payment year 2025
Other CMS Models
PACE (CMS-HCC V22): HCC 23 · ESRD (V21): HCC 23 · ESRD (V24): HCC 23
ESRD V21 weights: 0.013 dialysis, 0.234–0.359 functioning graft · ESRD V24 weights: 0.036 dialysis, 0.217–0.390 functioning graft
Part D (RxHCC)
RxHCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Achalasia of esophagus
  • ACTH deficiency
  • Adrenal atrophy
  • Adrenal calcification
  • Adrenal cortical hypofunction due to interruption of corticosteroid therapy
  • Adrenal gland hematoma
  • Adrenal hemorrhage
  • Adrenal infarction
  • Adrenal insufficiency due to adrenal metastasis
  • Adrenal necrosis
  • Adrenocortical hemorrhage
  • Adrenocorticotropic hormone resistance syndrome
  • Aldosterone deficiency
  • Atrophy of adrenal cortex
  • Autonomic neuropathy due to Allgrove syndrome
  • Congenital achalasia of esophagus
  • Congenital isolated adrenocorticotropic hormone deficiency
  • Degeneration of adrenal gland
  • Familial hyperreninemic hypoaldosteronism type 1A
  • Familial hyperreninemic hypoaldosteronism type 1B
  • Familial hyperreninemic hypoaldosteronism type 2
  • Familial hypoaldosteronism
  • Generalized glucocorticoid resistance syndrome
  • Glucocorticoid deficiency with achalasia
  • Hereditary glucocorticoid resistance
  • Hyperkalemic renal tubular acidosis
  • Hyperreninemic hypoaldosteronism
  • Hypoadrenalism due to paracoccidioidomycosis
  • Hypocortisolism secondary to another disorder
  • Hyporeninemic hypoaldosteronism
  • Isolated corticotropin deficiency
  • Mineralocorticoid deficiency
  • Pituitary thyroid hormone resistance
  • Primary adrenocortical insufficiency
  • Resistance to thyroid hormone syndrome

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E27.49: its own notes plus those printed at E27.4, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Adrenal hemorrhage
  • Adrenal infarction

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E27.4 Other and unspecified adrenocortical insufficiency applies to 2 codes
  • adrenoleukodystrophy [Addison-Schilder] (E71.528)
  • Waterhouse-Friderichsen syndrome (A39.1)
From Block E20-E35 Disorders of other endocrine glands applies to 99 codes
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E27.49, its category, or a range that includes it.

Code First 1

These codes say to code first a condition named in the note, and E27.49 is one of the conditions named.

  • G63 Polyneuropathy in diseases classified elsewhere
    endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34) names E20-E34, which includes this code

Notes 1

These notes mention E27.49.

  • Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases
    All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Addison Disease

Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E27.49 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
255.41 Glucocorticoid deficient
Approximate The match is approximate rather than exact.
ICD-9-CM
255.42 Mineralcorticoid defcnt
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E27.49Overview

What is the ICD-10 code for other adrenocortical insufficiency?

The ICD-10-CM code for other adrenocortical insufficiency is E27.49 (sometimes written as E2749). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E27.49 (Other and unspecified adrenocortical insufficiency) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other adrenocortical insufficiency on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E27.49 group to?

When other adrenocortical insufficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.

Is E27.49 a CC or MCC?

CMS lists E27.49 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 22 closely related codes in its exclusion list.

Can E27.49 be reported with E71.528?

Not as a rule. The Excludes1 note at E27.4, which applies to E27.49, lists "adrenoleukodystrophy [Addison-Schilder] (E71.528)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

Does E27.49 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage. E27.49 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).