2026 ICD-10-CM Diagnosis Code E27.49Other adrenocortical insufficiency

ICD-10-CM Codes›E00–E89›E20-E35›E27

ICD-10-CM E27.49
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E27.49 is a billable ICD-10-CM diagnosis code for other adrenocortical insufficiency. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E27.49
Billable Status
Yes — Valid for Submission
Code Describes
Other adrenocortical insufficiency
Short Description
Other adrenocortical insufficiency
Same as the full description in the CMS dataset.
Parent Code
E27.4
Other and unspecified adrenocortical insufficiency

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE27Other disorders of adrenal gland
This CodeE27.49Other adrenocortical insufficiency

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Achalasia of esophagus
  • ACTH deficiency
  • Adrenal atrophy
  • Adrenal calcification
  • Adrenal cortical hypofunction due to interruption of corticosteroid therapy
  • Adrenal gland hematoma
  • Adrenal hemorrhage
  • Adrenal infarction
  • Adrenal insufficiency due to adrenal metastasis
  • Adrenal necrosis
  • Adrenocortical hemorrhage
  • Adrenocorticotropic hormone resistance syndrome
  • Aldosterone deficiency
  • Atrophy of adrenal cortex
  • Autonomic neuropathy due to Allgrove syndrome
  • Congenital achalasia of esophagus
  • Congenital isolated adrenocorticotropic hormone deficiency
  • Degeneration of adrenal gland
  • Familial hyperreninemic hypoaldosteronism type 1A
  • Familial hyperreninemic hypoaldosteronism type 1B
  • Familial hyperreninemic hypoaldosteronism type 2
  • Familial hypoaldosteronism
  • Generalized glucocorticoid resistance syndrome
  • Glucocorticoid deficiency with achalasia
  • Hereditary glucocorticoid resistance
  • Hyperkalemic renal tubular acidosis
  • Hyperreninemic hypoaldosteronism
  • Hypoadrenalism due to paracoccidioidomycosis
  • Hypocortisolism secondary to another disorder
  • Hyporeninemic hypoaldosteronism
  • Injury of adrenal gland
  • Isolated corticotropin deficiency
  • Mineralocorticoid deficiency
  • Pituitary thyroid hormone resistance
  • Primary adrenocortical insufficiency
  • Resistance to thyroid hormone syndrome

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Adrenal hemorrhage
  • Adrenal infarction

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Atrophy, atrophic(of)
      • adrenal (capsule) (gland)
    • Atrophy, atrophic(of)
      • suprarenal (capsule) (gland)
    • Calcification
      • adrenal (capsule) (gland)
    • Calcification
      • suprarenal (capsule) (gland)
    • Deficiency, deficient
      • combined glucocorticoid and mineralocorticoid
    • Deficiency, deficient
      • glucocorticoid
    • Deficiency, deficient
      • glucocorticoid
        • mineralocorticoid
    • Deficiency, deficient
      • mineralocorticoid
    • Deficiency, deficient
      • mineralocorticoid
        • with glucocorticoid
    • Hemorrhage, hemorrhagic(concealed)
      • adrenal (capsule) (gland)
    • Hemorrhage, hemorrhagic(concealed)
      • suprarenal (capsule) (gland)
    • Infarct, infarction
      • adrenal (capsule) (gland)
    • Infarct, infarction
      • suprarenal (capsule) (gland)
    • Insensitivity
      • adrenocorticotropin hormone (ACTH)
    • Necrosis, necrotic(ischemic)
      • adrenal (capsule) (gland)
    • Necrosis, necrotic(ischemic)
      • suprarenal (capsule) (gland)

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Hyperreninemic Hypoaldosteronism

    hypoaldosteronism characterized by impaired secretion of aldosterone, despite increased renin activity. this condition may be caused by chronic or critical illness, aldosterone synthase deficiency or other genetic conditions.

  • Adrenal Hemorrhage

    hemorrhage and necrosis of the adrenal gland tissue. bilateral and extensive hemorrhage may lead to acute adrenal insufficiency, shock, and death.

Patient EducationClinical

Addison Disease

Your adrenal glands are just above your kidneys. The outside layer of these glands makes hormones that help your body respond to stress and regulate your blood pressure and water and salt balance. Addison disease happens if the adrenal glands don't make enough of these hormones.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E27.49 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
255.41 Glucocorticoid deficient
Approximate The match is approximate rather than exact.
ICD-9-CM
255.42 Mineralcorticoid defcnt
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E27.49Overview

Is E27.49 (Other and unspecified adrenocortical insufficiency) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report other adrenocortical insufficiency on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E27.49 group to?

When other adrenocortical insufficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E27.49?

Under the General Equivalence Mappings, other adrenocortical insufficiency converts to ICD-9-CM 255.41 (glucocorticoid deficient) and 255.42 (mineralcorticoid defcnt). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.