2027 ICD-10-CM Diagnosis Code E25.0Congenital adrenogenital disorders associated with enzyme deficiency

ICD-10-CM Codes›E00–E89›E20-E35›E25

ICD-10-CM E25.0
CMSSource: CMS FY 2027 ICD-10-CM dataset · Effective Oct 1, 2026 – Sep 30, 2027

E25.0 is a billable ICD-10-CM diagnosis code for congenital adrenogenital disorders associated with enzyme deficiency. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

E25.0 no longer risk-adjusts for Medicare Advantage: it mapped to HCC 23 under the retired CMS-HCC V24 model through payment year 2025 but maps to no category in the live V28 model. It still risk-adjusts in the PACE (CMS-HCC V22) category 23, ESRD (V21) category 23, ESRD (V24) category 23, and RxHCC Part D (V08) category 43 for payment year 2027.

Code Identity

ICD-10-CM Code
E25.0
Billable Status
Yes — Valid for Submission
Code Describes
Congenital adrenogenital disorders associated with enzyme deficiency
Short Description
Congenital adrenogenital disorders assoc w enzyme deficiency
Parent Code
E25
Adrenogenital disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE25Adrenogenital disorders
This CodeE25.0Congenital adrenogenital disorders associated with enzyme deficiency

Medicare Risk Adjustment (HCC)Billing

E25.0 no longer risk-adjusts for Medicare Advantage: it maps to no payment category in the live CMS-HCC V28 model, although it still risk-adjusts in the other CMS models shown below.

CMS-HCC V28 (Medicare Advantage Payment Model)
Not mapped
Dropped in V28 see all codes that no longer risk-adjust
Prior Model (CMS-HCC V24)
HCC 23
V24 retired last contributed to a Medicare Advantage risk score in payment year 2025
Other CMS Models
PACE (CMS-HCC V22): HCC 23 · ESRD (V21): HCC 23 · ESRD (V24): HCC 23
ESRD V21 weights: 0.013 dialysis, 0.234–0.359 functioning graft · ESRD V24 weights: 0.036 dialysis, 0.217–0.390 functioning graft
Part D (RxHCC)
RxHCC 43 — Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
also risk-adjusts in the Part D prescription drug model (V08)

Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • 17 alpha-Hydroxyprogesterone aldolase deficiency
  • 3 beta-Hydroxysteroid dehydrogenase deficiency
  • 3-Beta-hydroxy-delta-5-C27-steroid dehydrogenase deficiency
  • 46,XY disorder of sex development due to isolated 17,20-lyase deficiency
  • Adrenal virilism
  • Aldosterone deficiency
  • CAH - desmolase deficiency
  • Cholesterol monooxygenase deficiency
  • Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
  • Congenital adrenal hyperplasia
  • Congenital adrenal hyperplasia due to 21-hydroxylase deficiency non-classic form
  • Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency
  • Congenital adrenal hypoplasia, X-linked
  • Congenital hypoplasia of adrenal gland
  • Congenital lipoid adrenal hyperplasia due to STAR deficiency
  • Congenital lipoid adrenal hyperplasia due to steroidogenic acute regulatory protein deficiency classic form
  • Congenital lipoid adrenal hyperplasia due to steroidogenic acute regulatory protein deficiency non classic form
  • Corticosterone 18-monooxygenase deficiency
  • Deficiency of 3alpha-hydroxysteroid dehydrogenase
  • Deficiency of 3beta-hydroxysteroid dehydrogenase
  • Deficiency of steroid 11-beta-monooxygenase
  • Deficiency of steroid 21-monooxygenase
  • Disorder of cholesterol catabolism
  • Disorder of cholesterol metabolism
  • Female pseudohermaphroditism
  • Female pseudohermaphroditism due to congenital adrenal hyperplasia
  • Fetal endocrine disorder
  • Fetal virilism
  • Hyperandrogenism due to non-classic 21-hydroxylase deficiency
  • Hypertension due to congenital adrenal hyperplasia
  • Hypertension due to disorder of adrenal gland
  • Late onset congenital adrenal hyperplasia
  • Male pseudohermaphroditism
  • Male pseudohermaphroditism due to congenital adrenal hyperplasia
  • Mild steroid 21-hydroxylase deficiency
  • Moderate steroid 21-hydroxylase deficiency
  • Pseudohermaphrodite, female with adrenocortical disorder
  • Pseudohermaphroditism due to congenital adrenal hyperplasia
  • Salt-losing congenital adrenal hyperplasia
  • Salt-losing congenital adrenal hyperplasia with virilism
  • Severe steroid 21-hydroxylase deficiency
  • Steroid 21-monooxygenase deficiency, salt wasting type
  • Steroid 21-monooxygenase deficiency, simple virilizing type
  • Synthetic defect of bile acids
  • Virilization-adrenogenital syndrome
  • Virilizing syndrome of adrenal origin

Instructional NotesGuidance

Instructions from the official ICD-10-CM Tabular List that apply to E25.0: its own notes plus those printed at E25, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.

Includes

Further defines, or gives examples of, the content of the category.

From E25 Adrenogenital disorders applies to 3 codes
  • adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
  • Female adrenal pseudohermaphroditism
  • Female heterosexual precocious pseudopuberty
  • Male isosexual precocious pseudopuberty
  • Male macrogenitosomia praecox
  • Male sexual precocity with adrenal hyperplasia
  • Male virilization (female)

Applicable To

Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.

  • Congenital adrenal hyperplasia
  • 21-Hydroxylase deficiency
  • Salt-losing congenital adrenal hyperplasia

Excludes1

Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.

From E25 Adrenogenital disorders applies to 3 codes
  • indeterminate sex and pseudohermaphroditism (Q56)
  • chromosomal abnormalities (Q90-Q99)
From Block E20-E35 Disorders of other endocrine glands applies to 99 codes
From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Notes

General instructions on how these codes are used.

From Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases applies to 973 codes
  • All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.

Source: CMS ICD-10-CM Tabular List. How to read instructional notes.

Referenced in Other NotesGuidance

Instructional notes printed at other codes that name E25.0, its category, or a range that includes it.

Excludes1 8

These codes carry an Excludes1 note naming E25.0: they are not reported together with it, unless the two conditions are unrelated.

  • E24 Cushing's syndrome
    congenital adrenal hyperplasia (E25.0)
  • E30.1 Precocious puberty
    congenital adrenal hyperplasia (E25.0)
  • Block E70-E88 Metabolic disorders
    congenital adrenal hyperplasia (E25.0)
  • Q89.1 Congenital malformations of adrenal gland
    congenital adrenal hyperplasia (E25.0)
  • E30.1 Precocious puberty
    female heterosexual precocious pseudopuberty (E25.-) names E25.-, which includes this code
  • E30.1 Precocious puberty
    male isosexual precocious pseudopuberty (E25.-) names E25.-, which includes this code
  • Q56 Indeterminate sex and pseudohermaphroditism
    female pseudohermaphroditism with adrenocortical disorder (E25.-) names E25.-, which includes this code
  • Q89.1 Congenital malformations of adrenal gland
    adrenogenital disorders (E25.-) names E25.-, which includes this code

Code First 1

These codes say to code first a condition named in the note, and E25.0 is one of the conditions named.

  • G63 Polyneuropathy in diseases classified elsewhere
    endocrine disease, except diabetes (E00-E07, E15-E16, E20-E34) names E20-E34, which includes this code

Notes 1

These notes mention E25.0.

  • Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseases
    All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Adrenal Gland Disorders

Your adrenal glands are two small organs that sit on top of each kidney. The adrenal glands make different types of hormones you need to stay alive and healthy. Hormones are chemicals that travel in your bloodstream and control how different parts of your body work.

The full article covers:

  • What are adrenal glands?
  • What are adrenal gland disorders?
  • What causes adrenal gland disorders?
  • How are adrenal gland disorders diagnosed?
  • What are the treatments for adrenal gland disorders?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E25.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
255.2 Adrenogenital disorders
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2026No changes
FY 2027CurrentCurrent code set, no changesEffective October 1, 2026 through September 30, 2027.

Questions About E25.0Overview

What is the ICD-10 code for congenital adrenogenital disorders associated with enzyme deficiency?

The ICD-10-CM code for congenital adrenogenital disorders associated with enzyme deficiency is E25.0 (sometimes written as E250). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

Is E25.0 (Adrenogenital disorders) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report congenital adrenogenital disorders associated with enzyme deficiency on HIPAA-covered claims from October 1, 2026 through September 30, 2027.

What MS-DRG does E25.0 group to?

When congenital adrenogenital disorders associated with enzyme deficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.

Can E25.0 be reported with Q56?

Not as a rule. The Excludes1 note at E25, which applies to E25.0, lists "indeterminate sex and pseudohermaphroditism (Q56)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).

What is the ICD-9 equivalent of E25.0?

Under the General Equivalence Mappings, congenital adrenogenital disorders associated with enzyme deficiency converts to ICD-9-CM 255.2 (adrenogenital disorders). The mapping is approximate, so confirm the match fits the documentation.

Does E25.0 risk-adjust for Medicare Advantage payment?

Not for Medicare Advantage. E25.0 mapped to HCC 23 in the retired CMS-HCC V24 model, which last determined payment in 2025, but it maps to no category in the live V28 model; see all codes that no longer risk-adjust. It still risk-adjusts in the PACE (CMS-HCC V22) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V21) category 23 (Other Significant Endocrine and Metabolic Disorders), ESRD (V24) category 23 (Other Significant Endocrine and Metabolic Disorders), and RxHCC Part D (V08) category 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders).