2026 ICD-10-CM Diagnosis Code E25.0Congenital adrenogenital disorders associated with enzyme deficiency

ICD-10-CM Codes›E00–E89›E20-E35›E25

ICD-10-CM E25.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E25.0 is a billable ICD-10-CM diagnosis code for congenital adrenogenital disorders associated with enzyme deficiency. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Other specified and unspecified endocrine disorders.

Code Identity

ICD-10-CM Code
E25.0
Billable Status
Yes — Valid for Submission
Code Describes
Congenital adrenogenital disorders associated with enzyme deficiency
Short Description
Congenital adrenogenital disorders assoc w enzyme deficiency
Parent Code
E25
Adrenogenital disorders

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE25Adrenogenital disorders
This CodeE25.0Congenital adrenogenital disorders associated with enzyme deficiency

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • 17 alpha-Hydroxyprogesterone aldolase deficiency
  • 3 beta-Hydroxysteroid dehydrogenase deficiency
  • 3-Beta-hydroxy-delta-5-C27-steroid dehydrogenase deficiency
  • 46,XY disorder of sex development due to isolated 17,20-lyase deficiency
  • Adrenal virilism
  • Aldosterone deficiency
  • CAH - desmolase deficiency
  • Cholesterol monooxygenase deficiency
  • Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
  • Congenital adrenal hyperplasia
  • Congenital adrenal hyperplasia due to 21-hydroxylase deficiency non-classic form
  • Congenital adrenal hyperplasia due to cytochrome P450 oxidoreductase deficiency
  • Congenital adrenal hypoplasia, X-linked
  • Congenital hypoplasia of adrenal gland
  • Congenital lipoid adrenal hyperplasia due to STAR deficiency
  • Congenital lipoid adrenal hyperplasia due to steroidogenic acute regulatory protein deficiency classic form
  • Congenital lipoid adrenal hyperplasia due to steroidogenic acute regulatory protein deficiency non classic form
  • Corticosterone 18-monooxygenase deficiency
  • Deficiency of 3alpha-hydroxysteroid dehydrogenase
  • Deficiency of 3beta-hydroxysteroid dehydrogenase
  • Deficiency of steroid 11-beta-monooxygenase
  • Deficiency of steroid 21-monooxygenase
  • Disorder of cholesterol catabolism
  • Disorder of cholesterol metabolism
  • Female pseudohermaphroditism
  • Female pseudohermaphroditism due to congenital adrenal hyperplasia
  • Fetal endocrine disorder
  • Fetal virilism
  • Hyperandrogenism due to non-classic 21-hydroxylase deficiency
  • Hypertension due to congenital adrenal hyperplasia
  • Late onset congenital adrenal hyperplasia
  • Male pseudohermaphroditism
  • Male pseudohermaphroditism due to congenital adrenal hyperplasia
  • Mild steroid 21-hydroxylase deficiency
  • Moderate steroid 21-hydroxylase deficiency
  • Pseudohermaphrodite, female with adrenocortical disorder
  • Pseudohermaphroditism due to congenital adrenal hyperplasia
  • Salt-losing congenital adrenal hyperplasia
  • Salt-losing congenital adrenal hyperplasia with virilism
  • Severe steroid 21-hydroxylase deficiency
  • Steroid 21-monooxygenase deficiency, salt wasting type
  • Steroid 21-monooxygenase deficiency, simple virilizing type
  • Synthetic defect of bile acids
  • Virilization-adrenogenital syndrome
  • Virilizing syndrome of adrenal origin

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Congenital adrenal hyperplasia
  • 21-Hydroxylase deficiency
  • Salt-losing congenital adrenal hyperplasia

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Adrenogenital syndrome
      • congenital
    • Adrenogenital syndrome
      • salt loss
    • Adrenogenitalism, congenital
    • Defect, defective
      • 3-beta-hydroxysteroid dehydrogenase
    • Defect, defective
      • 11-hydroxylase
    • Defect, defective
      • 21-hydroxylase
    • Deficiency, deficient
      • 3-beta hydroxysteroid dehydrogenase
    • Deficiency, deficient
      • 11-hydroxylase
    • Deficiency, deficient
      • 21-hydroxylase
    • Hyperadrenocorticism
      • congenital
    • Hyperfunction
      • adrenal cortex, not associated with Cushing's syndrome
        • virilism
          • congenital
    • Hyperplasia, hyperplastic
      • adrenal (capsule) (cortex) (gland)
        • with
          • sexual precocity (male)
            • congenital
    • Hyperplasia, hyperplastic
      • adrenal (capsule) (cortex) (gland)
        • with
          • virilism, adrenal
            • congenital
    • Hyperplasia, hyperplastic
      • adrenal (capsule) (cortex) (gland)
        • with
          • virilization (female)
            • congenital
    • Hyperplasia, hyperplastic
      • adrenal (capsule) (cortex) (gland)
        • congenital
    • Hyperplasia, hyperplastic
      • adrenal (capsule) (cortex) (gland)
        • congenital
          • salt-losing
    • Macrogenitosomia(adrenal) (male) (praecox)
      • congenital
    • Masculinization(female) with adrenal hyperplasia
      • congenital
    • Precocity, sexual(constitutional) (cryptogenic) (female) (idiopathic) (male)
      • with adrenal hyperplasia
        • congenital
    • Pseudohermaphroditism
      • female
        • adrenal (congenital)
    • Syndrome
      • adrenogenital
        • congenital, associated with enzyme deficiency
    • Virilism(adrenal)
      • congenital
    • Virilization(female) (suprarenal)
      • congenital

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END015
Other specified and unspecified endocrine disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Patient EducationClinical

Adrenal Gland Disorders

Your adrenal glands are two small organs that sit on top of each kidney. The adrenal glands make different types of hormones you need to stay alive and healthy. Hormones are chemicals that travel in your bloodstream and control how different parts of your body work.

The full article covers:

  • What are adrenal glands?
  • What are adrenal gland disorders?
  • What causes adrenal gland disorders?
  • How are adrenal gland disorders diagnosed?
  • What are the treatments for adrenal gland disorders?

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E25.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
255.2 Adrenogenital disorders
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E25.0Overview

Is E25.0 (Adrenogenital disorders) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report congenital adrenogenital disorders associated with enzyme deficiency on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E25.0 group to?

When congenital adrenogenital disorders associated with enzyme deficiency is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E25.0?

Under the General Equivalence Mappings, congenital adrenogenital disorders associated with enzyme deficiency converts to ICD-9-CM 255.2 (adrenogenital disorders). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.