2026 ICD-10-CM Diagnosis Code E24.0Pituitary-dependent Cushing's disease

ICD-10-CM Codes›E00–E89›E20-E35›E24

ICD-10-CM E24.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

E24.0 is a billable ICD-10-CM diagnosis code for pituitary-dependent Cushing's disease. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 643 through 645. Coders also document this condition as ACTH hypersecretion. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Pituitary disorders.

Code Identity

ICD-10-CM Code
E24.0
Billable Status
Yes — Valid for Submission
Code Describes
Pituitary-dependent Cushing's disease
Short Description
Pituitary-dependent Cushing's disease
Same as the full description in the CMS dataset.
Parent Code
E24
Cushing's syndrome

Code Classification

ChapterE00–E89Endocrine, nutritional and metabolic diseases
SectionE20-E35Disorders of other endocrine glands
CategoryE24Cushing's syndrome
This CodeE24.0Pituitary-dependent Cushing's disease

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • ACTH hypersecretion
  • ACTH-dependent Cushing's syndrome
  • Adrenal hyperfunction
  • Adrenocortical hyperfunction
  • Hypercortisolism due to pituitary adenoma
  • Pituitary dependent hypercortisolism

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Overproduction of pituitary ACTH
  • Pituitary-dependent hypercorticalism

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Basophilism(cortico-adrenal) (Cushing's) (pituitary)
    • Cushing's
      • syndrome or disease
        • pituitary-dependent
    • Hyperadrenocorticism
      • pituitary-dependent
    • Hypercorticalism, pituitary-dependent
    • Hypersecretion
      • ACTH (not associated with Cushing's syndrome)
        • pituitary
    • Hypersecretion
      • hormone (s)
        • ACTH (not associated with Cushing's syndrome)
          • pituitary
    • Syndrome
      • Cushing's
        • due to
          • overproduction of pituitary ACTH
    • Syndrome
      • Cushing's
        • pituitary-dependent

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR END013
Pituitary disorders
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Adrenocortical Hyperfunction

    excess production of adrenal cortex hormones such as aldosterone; hydrocortisone; dehydroepiandrosterone; and/or androstenedione. hyperadrenal syndromes include cushing syndrome; hyperaldosteronism; and virilism.

Patient EducationClinical

Cushing's Syndrome

Cushing's syndrome is a hormonal disorder. The cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. Sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to Cushing's. Some kinds of tumors produce a hormone that can cause your body to make too much cortisol.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert E24.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
255.0 Cushing's syndrome
Approximate The match is approximate rather than exact.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About E24.0Overview

Is E24.0 (Cushing's syndrome) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report pituitary-dependent Cushing's disease on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does E24.0 group to?

When pituitary-dependent Cushing's disease is the principal diagnosis on an inpatient stay, it groups to MS-DRG 643, 644, 645, with relative weights from 0.7683 to 1.6461 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of E24.0?

Under the General Equivalence Mappings, pituitary-dependent Cushing's disease converts to ICD-9-CM 255.0 (Cushing's syndrome). The mapping is approximate, so confirm the match fits the documentation.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.