2027 ICD-10-CM Diagnosis Code E24.0Pituitary-dependent Cushing's disease
ICD-10-CM Codes›E00–E89›E20-E35›E24
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 51
- Chronic Condition
E24.0 is a billable ICD-10-CM diagnosis code for pituitary-dependent Cushing's disease. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 643 through 645. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 23 closely related codes. Coders also document this condition as ACTH hypersecretion. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Pituitary disorders.
For Medicare Advantage risk adjustment, E24.0 maps to CMS-HCC Category 51 (Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders) under the V28 model, adding a risk factor of about 0.510 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
E24.0 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- ACTH hypersecretion
- ACTH-dependent Cushing's syndrome
- Adrenal hyperfunction
- Adrenocortical hyperfunction
- Hypercortisolism due to pituitary adenoma
- Pituitary dependent hypercortisolism
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to E24.0: its own notes plus those printed at E24, block E20-E35, and Chapter 4. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Overproduction of pituitary ACTH
- Pituitary-dependent hypercorticalism
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Notes
General instructions on how these codes are used.
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name E24.0, its category, or a range that includes it.
Excludes1 3
These codes carry an Excludes1 note naming E24.0: they are not reported together with it, unless the two conditions are unrelated.
Code First 2
These codes say to code first a condition named in the note, and E24.0 is one of the conditions named.
Notes 1
These notes mention E24.0.
- Chapter 4 (E00-E89) Endocrine, nutritional and metabolic diseasesAll neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere. names E16-E31, which includes this code
Index to Diseases and InjuriesGuidance
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Cushing Syndrome
a condition caused by prolonged exposure to excess levels of cortisol (hydrocortisone) or other glucocorticoids from endogenous or exogenous sources. it is characterized by upper body obesity; osteoporosis; hypertension; diabetes mellitus; hirsutism; amenorrhea; and excess body fluid. endogenous cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of adrenocorticotropin and those that are acth-independent.
Patient EducationClinical
Cushing's Syndrome
Cushing's syndrome is a hormonal disorder. The cause is long-term exposure to too much cortisol, a hormone that your adrenal gland makes. Sometimes, taking synthetic hormone medicine to treat an inflammatory disease leads to Cushing's. Some kinds of tumors produce a hormone that can cause your body to make too much cortisol.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert E24.0 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About E24.0Overview
What is the ICD-10 code for pituitary-dependent Cushing's disease?
The ICD-10-CM code for pituitary-dependent Cushing's disease is E24.0 (sometimes written as E240). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is E24.0 (Cushing's syndrome) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report pituitary-dependent Cushing's disease on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does E24.0 group to?
When pituitary-dependent Cushing's disease is the principal diagnosis on an inpatient stay, it groups to MS-DRG 644, 645, 643, with relative weights from 0.7461 to 1.6138 depending on complications. Higher weights mean higher Medicare reimbursement.
Is E24.0 a CC or MCC?
CMS lists E24.0 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 23 closely related codes in its exclusion list.
Can E24.0 be reported with E25.0?
Not as a rule. The Excludes1 note at E24, which applies to E24.0, lists "congenital adrenal hyperplasia (E25.0)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What HCC is E24.0?
E24.0 (pituitary-dependent Cushing's disease) maps to CMS-HCC Category 51 (Addison's and Cushing's Diseases, Acromegaly, and Other Specified Endocrine Disorders), commonly written as HCC 51, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 23 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 42.
Does E24.0 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, E24.0 adds a risk adjustment factor of about 0.510 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.313 to 0.654 depending on the payment segment). HCC 51 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 51 category page.
