2027 ICD-10-CM Diagnosis Code D89.810Acute graft-versus-host disease
ICD-10-CM Codes›D50–D89›D80-D89›D89
- Billable — Valid for Submission
- CC — Complication or Comorbidity
- Risk Adjusts — HCC 454
- Not a Principal Diagnosis
- Chronic Condition
D89.810 is a billable ICD-10-CM diagnosis code for acute graft-versus-host disease. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 808 through 810. As a secondary diagnosis, it counts as a complication or comorbidity (CC) and moves an inpatient stay to a higher severity level within its MS-DRG family. It does not count, however, when the principal diagnosis is one of 47 closely related codes. The code is not accepted as a principal diagnosis by the Medicare Code Editor. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Complication of transplanted organs or tissue, initial encounter; and Immunity disorders.
For Medicare Advantage risk adjustment, D89.810 maps to CMS-HCC Category 454 (Stem Cell, Including Bone Marrow, Transplant Status/Complications) under the V28 model, adding a risk factor of about 1.068 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Code EditsBilling
Medicare Code Editor checks that affect claim validity for D89.810.
Medicare Risk Adjustment (HCC)Billing
D89.810 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Acute graft-versus-host disease
- Acute graft-versus-host disease following transplant of kidney
- Acute graft-versus-host reaction following bone marrow transplant
- Disorder due to grafting procedure
- Graft-versus-host disease following transplant of kidney
- Late acute graft-versus-host disease
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D89.810: its own notes plus those printed at D89.81, D89, block D80-D89, and Chapter 3. A note printed at a category, block or chapter applies to every code under it.
Includes
Further defines, or gives examples of, the content of the category.
- defects in the complement system
- immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
- sarcoidosis
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- transplant failure and rejection (T86.-)
- human immunodeficiency virus [HIV] disease (B20)
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Code First
The underlying condition named in the note is sequenced before this code.
Use Additional Code
Add a second code, after this one, to fully describe the condition.
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D89.810, its category, or a range that includes it.
Excludes1 1
These codes carry an Excludes1 note naming D89.810: they are not reported together with it, unless the two conditions are unrelated.
- D72 Other disorders of white blood cells
Use Additional Code 3
These codes say to use an additional code from the note, and D89.810 is one of the codes named.
- M31.11 Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]graft versus host disease (D89.81-) names D89.81-, which includes this code
- T80.89 Other complications following infusion, transfusion and therapeutic injectioncode to identify graft-versus-host reaction, if applicable, (D89.81-) names D89.81-, which includes this code
- T86 Complications of transplanted organs and tissuegraft-versus-host disease (D89.81-) names D89.81-, which includes this code
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Disease, diseased See Also: Syndrome;
graft-versus-host (GVH) D89.813
acute D89.810
acute D89.810
Graft-versus-host disease D89.813
acute D89.810
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Clinical InformationClinical
Acute Graft Versus Host Disease
a syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, usually affecting the skin, liver, and gi tract. the onset is usually within one hundred days of transplantation or immunologic manipulation.Graft vs Host Disease
the clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the graft vs host reaction.
Patient EducationClinical
Immune System and Disorders
Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.
The full article covers:
- What is the immune system?
- What are the parts of the immune system?
- How does the immune system work?
- What are the types of immunity?
- What can go wrong with the immune system?
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D89.810 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D89.810Overview
What is the ICD-10 code for acute graft-versus-host disease?
The ICD-10-CM code for acute graft-versus-host disease is D89.810 (sometimes written as D89810). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D89.810 (Graft-versus-host disease) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report acute graft-versus-host disease on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D89.810 group to?
On inpatient claims, acute graft-versus-host disease maps to MS-DRG 808, 809, 810, with relative weights from 1.0749 to 2.1706 depending on complications. Higher weights mean higher Medicare reimbursement.
Is D89.810 a CC or MCC?
CMS lists D89.810 as a CC (complication or comorbidity) for FY 2027. Reported as a secondary diagnosis, it moves the inpatient stay to a higher-weighted DRG within its severity family. It does not count when the principal diagnosis is one of the 47 closely related codes in its exclusion list.
Can D89.810 be a principal diagnosis?
No. The Medicare Code Editor rejects this code as a principal diagnosis because acute graft-versus-host disease describes a circumstance that influences health status rather than a current illness. Report it as a secondary diagnosis.
What HCC is D89.810?
D89.810 (acute graft-versus-host disease) maps to CMS-HCC Category 454 (Stem Cell, Including Bone Marrow, Transplant Status/Complications), commonly written as HCC 454, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 47 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. In the Part D prescription drug model it maps to RxHCC 395.
Does D89.810 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, D89.810 adds a risk adjustment factor of about 1.068 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.416 to 1.596 depending on the payment segment). HCC 454 sits at the top of its hierarchy, so no other condition category supersedes it. See the full factor table on the HCC 454 category page.
