2022 ICD-10-CM Code D89.83

Cytokine release syndrome

Version 2021

Not Valid for Submission

ICD-10:D89.83
Short Description:Cytokine release syndrome
Long Description:Cytokine release syndrome

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Certain disorders involving the immune mechanism (D80-D89)
      • Oth disorders involving the immune mechanism, NEC (D89)

D89.83 is a non-specific and non-billable diagnosis code code, consider using a code with a higher level of specificity for a diagnosis of cytokine release syndrome. The code is not specific and is NOT valid for the year 2022 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding for Cytokine release syndrome

Non-specific codes like D89.83 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for cytokine release syndrome:

  • BILLABLE CODE - Use D89.831 for Cytokine release syndrome, grade 1
  • BILLABLE CODE - Use D89.832 for Cytokine release syndrome, grade 2
  • BILLABLE CODE - Use D89.833 for Cytokine release syndrome, grade 3
  • BILLABLE CODE - Use D89.834 for Cytokine release syndrome, grade 4
  • BILLABLE CODE - Use D89.835 for Cytokine release syndrome, grade 5
  • BILLABLE CODE - Use D89.839 for Cytokine release syndrome, grade unspecified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with coding notes and guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code D89.83:


Code First

Code First
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.

Use Additional Code

Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.

Clinical Information

Code History

  • FY 2021 - No Change, effective from 10/1/2020 through 9/30/2021