D89.8 - Other specified disorders involving the immune mechanism, not elsewhere classified

Version 2023
ICD-10:D89.8
Short Description:Oth disrd involving the immune mechanism, NEC
Long Description:Other specified disorders involving the immune mechanism, not elsewhere classified
Status: Not Valid for Submission
Version:ICD-10-CM 2023
Code Classification:
  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Certain disorders involving the immune mechanism (D80-D89)
      • Oth disorders involving the immune mechanism, NEC (D89)

D89.8 is a non-specific and non-billable ICD-10 code code, consider using a code with a higher level of specificity for a diagnosis of other specified disorders involving the immune mechanism, not elsewhere classified. The code is not specific and is NOT valid for the year 2023 for the submission of HIPAA-covered transactions. Category or Header define the heading of a category of codes that may be further subdivided by the use of 4th, 5th, 6th or 7th characters.

Specific Coding for Oth disrd involving the immune mechanism, NEC

Non-specific codes like D89.8 require more digits to indicate the appropriate level of specificity. Consider using any of the following ICD-10 codes with a higher level of specificity when coding for oth disrd involving the immune mechanism, nec:

  • NON-BILLABLE CODE - D89.81 for Graft-versus-host disease
  • BILLABLE CODE - Use D89.810 for Acute graft-versus-host disease
  • BILLABLE CODE - Use D89.811 for Chronic graft-versus-host disease
  • BILLABLE CODE - Use D89.812 for Acute on chronic graft-versus-host disease
  • BILLABLE CODE - Use D89.813 for Graft-versus-host disease, unspecified
  • BILLABLE CODE - Use D89.82 for Autoimmune lymphoproliferative syndrome [ALPS]
  • NON-BILLABLE CODE - D89.83 for Cytokine release syndrome
  • BILLABLE CODE - Use D89.831 for Cytokine release syndrome, grade 1
  • BILLABLE CODE - Use D89.832 for Cytokine release syndrome, grade 2
  • BILLABLE CODE - Use D89.833 for Cytokine release syndrome, grade 3
  • BILLABLE CODE - Use D89.834 for Cytokine release syndrome, grade 4
  • BILLABLE CODE - Use D89.835 for Cytokine release syndrome, grade 5
  • BILLABLE CODE - Use D89.839 for Cytokine release syndrome, grade unspecified
  • BILLABLE CODE - Use D89.89 for Other specified disorders involving the immune mechanism, not elsewhere classified

Patient Education


Immune System and Disorders

What is the immune system?

Your immune system is a complex network of cells, tissues, and organs. Together they help the body fight infections and other diseases.

When germs such as bacteria or viruses invade your body, they attack and multiply. This is called an infection. The infection causes the disease that makes you sick. Your immune system protects you from the disease by fighting off the germs.

What are the parts of the immune system?

The immune system has many different parts, including:

How does the immune system work?

Your immune system defends your body against substances it sees as harmful or foreign. These substances are called antigens. They may be germs such as bacteria and viruses. They might be chemicals or toxins. They could also be cells that are damaged from things like cancer or sunburn.

When your immune system recognizes an antigen, it attacks it. This is called an immune response. Part of this response is to make antibodies. Antibodies are proteins that work to attack, weaken, and destroy antigens. Your body also makes other cells to fight the antigen.

Afterwards, your immune system remembers the antigen. If it sees the antigen again, it can recognize it. It will quickly send out the right antibodies, so in most cases, you don't get sick. This protection against a certain disease is called immunity.

What are the types of immunity?

There are three different types of immunity:

What can go wrong with the immune system?

Sometimes a person may have an immune response even though there is no real threat. This can lead to problems such as allergies, asthma, and autoimmune diseases. If you have an autoimmune disease, your immune system attacks healthy cells in your body by mistake.

Other immune system problems happen when your immune system does not work correctly. These problems include immunodeficiency diseases. If you have an immunodeficiency disease, you get sick more often. Your infections may last longer and can be more serious and harder to treat. They are often genetic disorders.

There are other diseases that can affect your immune system. For example, HIV is a virus that harms your immune system by destroying your white blood cells. If HIV is not treated, it can lead to AIDS (acquired immunodeficiency syndrome). People with AIDS have badly damaged immune systems. They get an increasing number of severe illnesses.


[Learn More in MedlinePlus]

Code History