ICD-10-CM Code D89.81

Graft-versus-host disease

Version 2020 Non-Billable Code

Not Valid for Submission

D89.81 is a "header" nonspecific and non-billable code code, consider using a code with a higher level of specificity for a diagnosis of graft-versus-host disease. The code is NOT valid for the year 2020 for the submission of HIPAA-covered transactions.

ICD-10:D89.81
Short Description:Graft-versus-host disease
Long Description:Graft-versus-host disease

Consider the following ICD-10 codes with a higher level of specificity:

  • D89.810 - Acute graft-versus-host disease
  • D89.811 - Chronic graft-versus-host disease
  • D89.812 - Acute on chronic graft-versus-host disease
  • D89.813 - ... unspecified

Tabular List of Diseases and Injuries

The Tabular List of Diseases and Injuries is a list of ICD-10 codes, organized "head to toe" into chapters and sections with guidance for inclusions, exclusions, descriptions and more. The following references are applicable to the code D89.81:

Code First

Code First
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. For such conditions, the ICD-10-CM has a coding convention that requires the underlying condition be sequenced first followed by the manifestation. Wherever such a combination exists, there is a "use additional code" note at the etiology code, and a "code first" note at the manifestation code. These instructional notes indicate the proper sequencing order of the codes, etiology followed by manifestation.
  • underlying cause, such as:
  • complications of transplanted organs and tissue T86
  • complications of blood transfusion T80.89

Use Additional Code

Use Additional Code
The “use additional code” indicates that a secondary code could be used to further specify the patient’s condition. This note is not mandatory and is only used if enough information is available to assign an additional code.
  • code to identify associated manifestations, such as:
  • desquamative dermatitis L30.8
  • diarrhea R19.7
  • elevated bilirubin R17
  • hair loss L65.9

Clinical Information

  • GRAFT VS HOST DISEASE-. the clinical entity characterized by anorexia diarrhea loss of hair leukopenia thrombocytopenia growth retardation and eventual death brought about by the graft vs host reaction.

Code Classification

  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50–D89)
    • Certain disorders involving the immune mechanism (D80-D89)
      • Oth disorders involving the immune mechanism, NEC (D89)

Code History

  • FY 2016 - New Code, effective from 10/1/2015 through 9/30/2016
    (First year ICD-10-CM implemented into the HIPAA code set)
  • FY 2017 - No Change, effective from 10/1/2016 through 9/30/2017
  • FY 2018 - No Change, effective from 10/1/2017 through 9/30/2018
  • FY 2019 - No Change, effective from 10/1/2018 through 9/30/2019
  • FY 2020 - No Change, effective from 10/1/2019 through 9/30/2020

Information for Patients


Immune System and Disorders

Your immune system is a complex network of cells, tissues, and organs that work together to defend against germs. It helps your body to recognize these "foreign" invaders. Then its job is to keep them out, or if it can't, to find and destroy them.

If your immune system cannot do its job, the results can be serious. Disorders of the immune system include

  • Allergy and asthma - immune responses to substances that are usually not harmful
  • Immune deficiency diseases - disorders in which the immune system is missing one or more of its parts
  • Autoimmune diseases - diseases causing your immune system to attack your own body's cells and tissues by mistake

[Learn More]