2026 ICD-10-CM Diagnosis Code D72.0Genetic anomalies of leukocytes

ICD-10-CM Codes›D50–D89›D70-D77›D72

ICD-10-CM D72.0
CMSSource: CMS FY 2026 ICD-10-CM dataset · Effective Oct 1, 2025 – Sep 30, 2026

D72.0 is a billable ICD-10-CM diagnosis code for genetic anomalies of leukocytes. It is valid on HIPAA claims for fiscal year 2026 (October 1, 2025 through September 30, 2026) and groups to MS-DRG 808 through 810. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diseases of white blood cells.

Code Identity

ICD-10-CM Code
D72.0
Billable Status
Yes — Valid for Submission
Code Describes
Genetic anomalies of leukocytes
Short Description
Genetic anomalies of leukocytes
Same as the full description in the CMS dataset.
Parent Code
D72
Other disorders of white blood cells

Code Classification

ChapterD50–D89Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
SectionD70-D77Other disorders of blood and blood-forming organs
CategoryD72Other disorders of white blood cells
This CodeD72.0Genetic anomalies of leukocytes

Approximate SynonymsGuidance

Alternate terms and clinical phrases that map to this code.

  • Combined phagocytic defect
  • Congenital atrophy of optic nerve
  • De Vaal's syndrome
  • Defective phagocytic cell adhesion
  • Genetic anomaly of leukocyte
  • Hereditary hypersegmentation
  • Hereditary neutrophilia
  • Hypersegmentation
  • Leukocyte adhesion deficiency
  • Leukocyte adhesion deficiency - type 1
  • Leukocyte adhesion deficiency - type 2
  • Leukocyte adhesion deficiency type III
  • Neutrophilia
  • Neutrophilia disorder
  • Pelger-Huët anomaly
  • Pelger-Huët cell
  • Reticular dysgenesis
  • Reticular dysgenesis with congenital aleukocytosis
  • SCID due to absent peripheral T cell maturation
  • Short stature, optic nerve atrophy, Pelger-Huët anomaly syndrome

Tabular List NotesGuidance

Coding notes and annotation back-references applicable to this code.

Inclusion Terms

  • Alder (granulation) (granulocyte) anomaly
  • Alder syndrome
  • Hereditary leukocytic hypersegmentation
  • Hereditary leukocytic hyposegmentation
  • Hereditary leukomelanopathy
  • May-Hegglin (granulation) (granulocyte) anomaly
  • May-Hegglin syndrome
  • Pelger-Huët (granulation) (granulocyte) anomaly
  • Pelger-Huët syndrome

Type 1 Excludes

  • Chédiak -Steinbrinck-Higashi syndrome E70.330

Index to Diseases and InjuriesGuidance

Alphabetical index entries that point to this code.

External Cause of Injuries IndexGuidance

References for this code in the External Cause of Injuries Index.

    • Alder(-Reilly) anomaly or syndrome (leukocyte granulation)
    • Anomaly, anomalous(congenital) (unspecified type)
      • Alder (-Reilly) (leukocyte granulation)
    • Anomaly, anomalous(congenital) (unspecified type)
      • granulation or granulocyte, genetic (constitutional) (leukocyte)
    • Anomaly, anomalous(congenital) (unspecified type)
      • Hegglin's
    • Anomaly, anomalous(congenital) (unspecified type)
      • hypersegmentation of neutrophils, hereditary
    • Anomaly, anomalous(congenital) (unspecified type)
      • Jordan's
    • Anomaly, anomalous(congenital) (unspecified type)
      • leukocytes, genetic
    • Anomaly, anomalous(congenital) (unspecified type)
      • leukocytes, genetic
        • granulation (constitutional)
    • Anomaly, anomalous(congenital) (unspecified type)
      • May (-Hegglin)
    • Anomaly, anomalous(congenital) (unspecified type)
      • Pelger-Huët (hereditary hyposegmentation)
    • Dohle body panmyelopathic syndrome
    • Dysgenesis
      • reticular
    • Hegglin's anomaly or syndrome
    • Hypersegmentation, leukocytic, hereditary
    • Hyposegmentation, leukocytic, hereditary
    • Inclusion
      • azurophilic leukocytic
    • Jordan's anomaly or syndrome
    • Leukomelanopathy, hereditary
    • May(-Hegglin) anomaly or syndrome
    • Neutrophilia, hereditary giant
    • Pelger-Huët anomaly or syndrome
    • Syndrome
      • Alder's
    • Syndrome
      • Döhle body-panmyelopathic
    • Syndrome
      • Hegglin's
    • Syndrome
      • May (-Hegglin)
    • Syndrome
      • Pelger-Huet

Clinical ClassificationClinical

AHRQ’s CCSR groups this code into broader clinical categories.

CCSR BLD007
Diseases of white blood cells
Default principal diagnosis: inpatient Yes · outpatient Yes

Clinical InformationClinical

  • Reticular Dysgenesis

    a rare severe combined immunodeficiency disorder characterized by congenital agranulocytosis, lymphoid tissue and thymic tissue hypoplasia, and lymphopenia. both cellular and humoral immunities are absent.

  • Leukocyte Adhesion Deficiency

    a rare autosomal recessive immunodeficiency disorder caused by deficiency of cd18 expression. it is characterized by defects in neutrophil adhesion and bacterial infections.

  • Leukocyte Adhesion Deficiency Type 1|LAD-1|LAD-1 Deficiency|LAD-Type I|LAD1|LFA-I Deficiency|LFA1 Immunodeficiency

    a rare immunodeficiency with an autosomal recessive pattern of inheritance. it is caused by mutation in the itgb2 gene on chromosome 21 which codes for the beta subunit of beta-2 integrin (cd18). the mutation results in significantly reduced or absent expression of cd18 on the surface of leukocytes which impairs their ability to migrate and interact with antigens. initial clinical signs include omphalitis and delayed separation of the umbilical cord. the clinical course is marked by recurrent bacterial and fungal infection without pus formation. in instances where there is < 1% expression of cd18, prognosis is dismal with a high likelihood for life-threatening infection within the first year of life.

  • Leukocyte Adhesion Deficiency Type 2|CDGIIc|Congenital Disorder of Glycosylation Type IIc|LAD-Type II|Sialyl-Lewis X Defect

    leukocyte adhesion deficiency, type ii. an inherited disease affecting the metabolism of fucose, which affects the expression of the sialyl lewis x antigen, the fucose-containing ligand for e- and p-selectins, resulting in a deficiency in neutrophil adhesion. syn sialyl-lewis x defect.

  • Leukocyte Adhesion Deficiency Type 3|LAD-3|LAD-III

    an autosomal recessive condition caused by mutation(s) in the fermt3 gene, encoding fermitin family homolog 3. it is characterized by a defect in activation of all beta integrins. it manifests clinically as severe infections with marked leukocytosis, accompanied by life-threatening bleeding episodes.

Patient EducationClinical

Blood Disorders

Your blood is living tissue made up of liquid and solids. The liquid part, called plasma, is made of water, salts and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells and platelets.

Read the full article at MedlinePlus

Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.

Convert D72.0 to ICD-9-CMHistory

The closest ICD-9-CM equivalents under the General Equivalence Mappings.

ICD-9-CM
288.2 Genetic anomaly leukocyt
Exact Match The mapping is direct, with no qualifiers.

Code HistoryHistory

FY 2016AddedAdded to the ICD-10-CM code setEffective October 1, 2015, the first year of ICD-10-CM.
FY 2017–2025No changes
FY 2026CurrentCurrent code set, no changesEffective October 1, 2025 through September 30, 2026.

Questions About D72.0Overview

Is D72.0 (Other disorders of white blood cells) a billable code?

Yes. This is a billable ICD-10-CM code, specific enough to report genetic anomalies of leukocytes on HIPAA-covered claims from October 1, 2025 through September 30, 2026.

What MS-DRG does D72.0 group to?

When genetic anomalies of leukocytes is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0466 to 2.2079 depending on complications. Higher weights mean higher Medicare reimbursement.

What is the ICD-9 equivalent of D72.0?

Under the General Equivalence Mappings, genetic anomalies of leukocytes converts to ICD-9-CM 288.2 (genetic anomaly leukocyt). The mapping is a direct match.

Footnotes

[1] Chronic - a chronic condition code indicates a condition lasting 12 months or longer and its effect on the patient based on one or both of the following criteria:

  • The condition results in the need for ongoing intervention with medical products,treatment, services, and special equipment
  • The condition places limitations on self-care, independent living, and social interactions.