2027 ICD-10-CM Diagnosis Code D72.0Genetic anomalies of leukocytes
ICD-10-CM Codes›D50–D89›D70-D77›D72
- Billable — Valid for Submission
- Risk Adjusts — HCC 115
- Chronic Condition
D72.0 is a billable ICD-10-CM diagnosis code for genetic anomalies of leukocytes. It is valid on HIPAA claims for fiscal year 2027 (October 1, 2026 through September 30, 2027) and groups to MS-DRG 808 through 810. In AHRQ's Clinical Classifications Software (CCSR), this diagnosis falls under Diseases of white blood cells.
For Medicare Advantage risk adjustment, D72.0 maps to CMS-HCC Category 115 (Specified Immunodeficiencies and White Blood Cell Disorders) under the V28 model, adding a risk factor of about 0.565 for a community, non-dual, aged beneficiary in payment year 2027.
Code Identity
Code Classification
Medicare Risk Adjustment (HCC)Billing
D72.0 maps to a payment category in the CMS-HCC model used to risk-adjust Medicare Advantage payments. Weights are the published community factors for payment year 2027.
Source: CMS Payment Year 2027 risk adjustment mappings and model software. Weights are relative factors, not dollar amounts; a beneficiary's total RAF also includes demographics and interactions. Browse all CMS-HCC categories.
Approximate SynonymsGuidance
Alternate terms and clinical phrases that map to this code.
- Combined phagocytic defect
- Congenital atrophy of optic nerve
- De Vaal's syndrome
- Defective phagocytic cell adhesion
- Genetic anomaly of leukocyte
- Global developmental delay, intellectual disability, facial dysmorphism, pseudo Pelger-Huët anomaly syndrome
- Hereditary hypersegmentation
- Hereditary neutrophilia
- Hypersegmentation
- Leukocyte adhesion deficiency
- Leukocyte adhesion deficiency - type 1
- Leukocyte adhesion deficiency - type 2
- Leukocyte adhesion deficiency type III
- Neutrophilia
- Neutrophilia disorder
- Pelger-Huët anomaly
- Pelger-Huët cell
- Reticular dysgenesis
- Reticular dysgenesis with congenital aleukocytosis
- SCID due to absent peripheral T cell maturation
- Short stature, optic nerve atrophy, Pelger-Huët anomaly syndrome
Instructional NotesGuidance
Instructions from the official ICD-10-CM Tabular List that apply to D72.0: its own notes plus those printed at D72 and Chapter 3. A note printed at a category, block or chapter applies to every code under it.
Applicable To
Conditions this code is used for: synonyms of the title or, for "other specified" codes, the conditions assigned to it. The list is not exhaustive.
- Alder (granulation) (granulocyte) anomaly
- Alder syndrome
- Hereditary leukocytic hypersegmentation
- Hereditary leukocytic hyposegmentation
- Hereditary leukomelanopathy
- May-Hegglin (granulation) (granulocyte) anomaly
- May-Hegglin syndrome
- Pelger-Huët (granulation) (granulocyte) anomaly
- Pelger-Huët syndrome
Excludes1
Not coded here: the excluded code is never reported together with this one, unless the two conditions are unrelated.
- Chédiak (-Steinbrinck)-Higashi syndrome (E70.330)
Excludes2
Not included here: the excluded condition is not part of this code, but a patient may have both, so both codes may be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Source: CMS ICD-10-CM Tabular List. How to read instructional notes.
Referenced in Other NotesGuidance
Instructional notes printed at other codes that name D72.0, its category, or a range that includes it.
Excludes2 1
These codes carry an Excludes2 note naming D72.0: its condition is not part of those codes, and both may be reported when the patient has both.
- Block R70-R79 Abnormal findings on examination of blood, without diagnosis
Index to Diseases and InjuriesGuidance
Alphabetical index entries that point to this code.
Anomaly, anomalous (congenital) (unspecified type) Q89.9
granulation or granulocyte, genetic (constitutional) (leukocyte) D72.0
Hegglin's D72.0
Jordan's D72.0
leukocytes, genetic D72.0
May (-Hegglin) D72.0
reticular D72.0
Syndrome See Also: Disease;
Alder's D72.0
Hegglin's D72.0
May (-Hegglin) D72.0
Pelger-Huet D72.0
Clinical ClassificationClinical
AHRQ’s CCSR groups this code into broader clinical categories.
Patient EducationClinical
Blood Disorders
Your blood is living tissue made up of liquid and solids. The liquid part, called plasma, is made of water, salts and protein. Over half of your blood is plasma. The solid part of your blood contains red blood cells, white blood cells and platelets.
Read the full article at MedlinePlus
Courtesy of MedlinePlus, a service of the U.S. National Library of Medicine.
Convert D72.0 to ICD-9-CMHistory
The closest ICD-9-CM equivalents under the General Equivalence Mappings.
Code HistoryHistory
Questions About D72.0Overview
What is the ICD-10 code for genetic anomalies of leukocytes?
The ICD-10-CM code for genetic anomalies of leukocytes is D72.0 (sometimes written as D720). It is billable on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
Is D72.0 (Other disorders of white blood cells) a billable code?
Yes. This is a billable ICD-10-CM code, specific enough to report genetic anomalies of leukocytes on HIPAA-covered claims from October 1, 2026 through September 30, 2027.
What MS-DRG does D72.0 group to?
When genetic anomalies of leukocytes is the principal diagnosis on an inpatient stay, it groups to MS-DRG 808, 809, 810, with relative weights from 1.0749 to 2.1706 depending on complications. Higher weights mean higher Medicare reimbursement.
Can D72.0 be reported with E70.330?
Not as a rule. The Excludes1 note on D72.0 lists "Chédiak (-Steinbrinck)-Higashi syndrome (E70.330)". An Excludes1 note means the excluded code is never reported together with this one; the only exception is when the two conditions are unrelated to each other (Official Guidelines, Section I.A.12.a).
What is the ICD-9 equivalent of D72.0?
Under the General Equivalence Mappings, genetic anomalies of leukocytes converts to ICD-9-CM 288.2 (genetic anomaly leukocyt). The mapping is a direct match.
What HCC is D72.0?
D72.0 (genetic anomalies of leukocytes) maps to CMS-HCC Category 115 (Specified Immunodeficiencies and White Blood Cell Disorders), commonly written as HCC 115, in the CMS-HCC V28 model used for Medicare Advantage risk adjustment in payment year 2027. It mapped to HCC 47 under the retired V24 model. It also maps in the PACE (CMS-HCC V22), ESRD (V21), and ESRD (V24) models. It does not map to any RxHCC in the Part D prescription drug model.
Does D72.0 risk-adjust for Medicare Advantage payment?
Yes. When documented and reported on a Medicare Advantage encounter, D72.0 adds a risk adjustment factor of about 0.565 to the beneficiary's RAF score for a community, non-dual, aged enrollee (published V28 weights range from 0.302 to 0.692 depending on the payment segment). A more severe related category (HCC 114) supersedes it when both are reported. See the full factor table on the HCC 115 category page.
